Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Anna, Spence"'
Autor:
Mototsugu Ito, Mark Walzer, Mary Beth Blauwet, Anna Spence, Nakyo Heo, Debra Kelsh, Paul Blahunka, Jay Erdman, Mohamad Nour Alsharif, Gerard J Marek
Publikováno v:
Journal of Psychopharmacology. 37:449-461
Background: Recent increases in opioid use and subsequent opioid use disorder are a major public health crisis in the United States. Aims: This phase 1 randomized, placebo-controlled study investigated the safety, tolerability, and pharmacokinetics (
Autor:
Mototsugu Ito, Mark Walzer, Mary Beth Blauwet, Anna Spence, Nakyo Heo, Debra Kelsh, Paul Blahunka, Jay Erdman, Mohamad Nour Alsharif, Gerard J Marek
Publikováno v:
Journal of Psychopharmacology. 37:144-154
Background: There is an unmet need for therapeutics with greater efficacy and tolerability for the treatment of opioid use disorder (OUD). ASP8062 is a novel compound with positive allosteric modulator activity on the γ-aminobutyric acid type B rece
Autor:
Mototsugu, Ito, Anna, Spence, Mary Beth, Blauwet, Nakyo, Heo, Ronald, Goldwater, Paul, Maruff, Gerard J, Marek
Publikováno v:
Journal of Psychopharmacology. 36:756-767
Background: ASP8062 is a novel orally active GABAB receptor positive allosteric modulator in clinical development for the treatment of alcohol use disorder (AUD) and opioid use disorder (OUD). Aims: This study assessed the potential pharmacokinetic/p