Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Anna, Signorile"'
Autor:
Livia Cosentino, Chiara Urbinati, Chiara Lanzillotta, Domenico De Rasmo, Daniela Valenti, Mattia Pellas, Maria Cristina Quattrini, Fabiana Piscitelli, Magdalena Kostrzewa, Fabio Di Domenico, Donatella Pietraforte, Tiziana Bisogno, Anna Signorile, Rosa Anna Vacca, Bianca De Filippis
Publikováno v:
Molecular Autism, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Background Defective mitochondria and aberrant brain mitochondrial bioenergetics are consistent features in syndromic intellectual disability disorders, such as Rett syndrome (RTT), a rare neurologic disorder that severely affects mainly fem
Externí odkaz:
https://doaj.org/article/8f0a63e3f3f04232b7cd24a12f9c6f55
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Barth syndrome (BTHS) is a lethal rare genetic disorder, which results in cardiac dysfunction, severe skeletal muscle weakness, immune issues and growth delay. Mutations in the TAFAZZIN gene, which is responsible for the remodeling of the ph
Externí odkaz:
https://doaj.org/article/bd99352d6bd84af2b909662bdf12f186
Autor:
Maria Laura Matrella, Alessio Valletti, Isabella Gigante, Domenico De Rasmo, Anna Signorile, Silvia Russo, Simona Lobasso, Donatella Lobraico, Michele Dibattista, Consiglia Pacelli, Tiziana Cocco
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract Neurons are highly dependent on mitochondria to meet their bioenergetic needs and understanding the metabolic changes during the differentiation process is crucial in the neurodegeneration context. Several in vitro approaches have been devel
Externí odkaz:
https://doaj.org/article/5c8b42df32784d119ae436696a9b2e05
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Barth Syndrome (BTHS), a genetic disease associated with early-onset cardioskeletal myopathy, is caused by loss-of-function mutations of the TAFAZZIN gene, which is responsible for remodeling the mitochondrial phospholipid cardiolipin (CL).
Externí odkaz:
https://doaj.org/article/4bddceabbf834473b6b9a223489faf21
Autor:
Anna Signorile, Domenico De Rasmo
Publikováno v:
Antioxidants, Vol 12, Iss 2, p 221 (2023)
In mammals during aging, reactive oxygen species (ROS), produced by the mitochondrial respiratory chain, cause oxidative damage of macromolecules leading to respiratory chain dysfunction, which in turn increases ROS mitochondrial production. Many eff
Externí odkaz:
https://doaj.org/article/7927bf5a23f6413183dd15cd914e9f19
Autor:
Anna Signorile, Anna Ferretta, Consiglia Pacelli, Nazzareno Capitanio, Paola Tanzarella, Maria Laura Matrella, Alessio Valletti, Domenico De Rasmo, Tiziana Cocco
Publikováno v:
Biomolecules, Vol 11, Iss 10, p 1511 (2021)
Parkin plays an important role in ensuring efficient mitochondrial function and calcium homeostasis. Parkin-mutant human fibroblasts, with defective oxidative phosphorylation activity, showed high basal cAMP level likely ascribed to increased activit
Externí odkaz:
https://doaj.org/article/846e06f51b494ffe87c0c8b0e222c6d4
Autor:
Ines Amara, Maria Laura Ontario, Maria Scuto, Gianluigi Maria Lo Dico, Sebastiano Sciuto, Valentina Greco, Salwa Abid-Essefi, Anna Signorile, Angela Trovato Salinaro, Vittorio Calabrese
Publikováno v:
Antioxidants, Vol 10, Iss 4, p 532 (2021)
Moringa oleifera (MO) is a medicinal plant that has been shown to possess antioxidant, anticarcinogenic and antibiotic activities. In a rat model, MO extract (MOe) has been shown to have a protective effect against brain damage and memory decline. As
Externí odkaz:
https://doaj.org/article/0c79fb996b924e69a5aef7a573b559bf
Autor:
Anna Signorile, Anna Ferretta, Maddalena Ruggieri, Damiano Paolicelli, Paolo Lattanzio, Maria Trojano, Domenico De Rasmo
Publikováno v:
Antioxidants, Vol 10, Iss 1, p 21 (2020)
Multiple sclerosis (MS) is a complex inflammatory and neurodegenerative chronic disease that involves the immune and central nervous systems (CNS). The pathogenesis involves the loss of blood–brain barrier integrity, resulting in the invasion of ly
Externí odkaz:
https://doaj.org/article/2e604f67dba7404d8ed976bd598857f2
Autor:
Domenico De Rasmo, Anna Ferretta, Silvia Russo, Maddalena Ruggieri, Piergiorgio Lasorella, Damiano Paolicelli, Maria Trojano, Anna Signorile
Publikováno v:
Biomedicines, Vol 8, Iss 4, p 85 (2020)
Multiple sclerosis (MS) is an autoimmune disease in which activated lymphocytes affect the central nervous system. Increase of reactive oxygen species (ROS), impairment of mitochondria-mediated apoptosis and mitochondrial alterations have been report
Externí odkaz:
https://doaj.org/article/3785b603b2204becb8a3aa34921ef747
Autor:
Anna Signorile, Consiglia Pacelli, Luigi Leonardo Palese, Arcangela Santeramo, Emilio Roca, Tiziana Cocco, Domenico De Rasmo
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 17; Pages: 9655
The oxidative phosphorylation (OXPHOS) system couples the transfer of electrons to oxygen with pumping of protons across the inner mitochondrial membrane, ensuring the ATP production. Evidence suggests that respiratory chain complexes may also assemb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2ba0980f5eb25969dcf43468adce5b0