Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Anna, Sava"'
Autor:
Nadia M J Rupniak, Elisabetta Perdona, Cristiana Griffante, Palmina Cavallini, Anna Sava, Daniel J Ricca, Karl B Thor, Edward C Burgard, Mauro Corsi
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0205894 (2018)
A series of peptide NK2 receptor agonists was evaluated for affinity, potency, efficacy, and selectivity at human recombinant NK2 and NK1 receptors expressed in CHO cells to identify compounds with the greatest separation between NK2 and NK1 receptor
Externí odkaz:
https://doaj.org/article/d70499d02d034dafa8d7da3ed632d030
Autor:
Peng Gao, Paolo Vincetti, Fabio Maria Sabbatini, Holly J. Carlisle, Luisa Mengatto, Stéphane De Lombaert, Anna Sava, Kerry Zobel, Xinying Liu, Claudia Beato, Jessica M. Bright, Alyssa M. A. Toda, Elena Serra, Federica Budassi, Marco Migliore, Laura Caberlotto, Cristiana Griffante, Silvia Bernardi, Mingliang Zhang, Albert W. Garofalo, Daniele Andreotti
Publikováno v:
Journal of Medicinal Chemistry. 63:14821-14839
Pathogenic variants in the leucine-rich repeat kinase 2 (LRRK2) gene have been identified that increase the risk for developing Parkinson's disease in a dominantly inherited fashion. These pathogenic variants, of which G2019S is the most common, caus
Autor:
Nadia M.J. Rupniak, Cristiana Griffante, Mauro Corsi, Palmina Cavallini, Karl B. Thor, Anna Sava, Elisabetta Perdona, Daniel J. Ricca
Publikováno v:
Neurosci Lett
The affinity, potency, efficacy, and selectivity of the NK2 receptor agonist GR64349 ([Lys(3),Gly(8),-R-γ-lactam-Leu(9)]-NKA(3-10)) at human recombinant NK2 and NK1 receptors was examined. In radioligand binding studies, GR64349 displaced [(125)I]-N
Autor:
Aldo Feriani, Laura Zonzini, Laura Castelletti, Selena Nola, Michele Dal Cin, Teresa Semeraro, Sylvie Gehanne, Silvia Tomelleri, Filippo Visentini, Palmina Cavallini, Susanna Cremonesi, Annalisa Pellacani, Anna Sava, Alessia Bacchi, Andrea Wong, Simone Braggio, Luca Tarsi, Mahmud Kajbaf, Paolo Cavanni, Elisabetta Perdona, Christian Heidbreder, Luciano Marchiò, Beatrice Oliosi, Fabrizio Micheli
Publikováno v:
Journal of Medicinal Chemistry. 59:8549-8576
A novel series of 1,2,4-triazolyl 5-azaspiro[2.4]heptanes with high affinity and selectivity at the dopamine (DA) D3 receptor (D3R) is described. Some of these compounds also have high selectivity over the hERG channel and were characterized with res
Autor:
Anna Sava, Palmina Cavallini, Daniel J. Ricca, Nadia M.J. Rupniak, Mauro Corsi, Elisabetta Perdona, Edward C. Burgard, Karl B. Thor, Cristiana Griffante
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0205894 (2018)
PLoS ONE
PLoS ONE
A series of peptide NK2 receptor agonists was evaluated for affinity, potency, efficacy, and selectivity at human recombinant NK2 and NK1 receptors expressed in CHO cells to identify compounds with the greatest separation between NK2 and NK1 receptor
Autor:
Kay Maltby, Stuart J Mundell, Edward T. Bullmore, Anna Sava, Graeme Henderson, Adelheid Roth, Eamonn Kelly, Antonio Felici, Pradeep J. Nathan
Publikováno v:
Psychopharmacology
Rationale The novel opioid receptor antagonist, GSK1421498, has been shown to attenuate reward-driven compulsive behaviours, such as stimulant drug seeking or binge eating, in animals and humans. Here, we report new data on the receptor pharmacology
Autor:
Anna Sava, Luca Tarsi, Simone Braggio, Teresa Semeraro, Aldo Feriani, Laura Zonzini, Fabrizio Micheli, Beatrice Oliosi, Susanna Cremonesi, Elisabetta Perdona, Silvia Tomelleri, Paolo Cavanni, Christian Heidbreder
Publikováno v:
Bioorganicmedicinal chemistry letters. 26(4)
A new series of morpholine derivatives has been identified as selective DA D3 receptor antagonists; their in vitro profile and pharmacokinetic data are provided.
Autor:
Ilaria Sartori, Laura Zonzini, Laurie J. Gordon, Angela Worby, Stefano Fontana, Manuela Borriello, Silvia Bison, Jeannette M. Watson, Steven Mark Bromidge, Giovanna Dal Forno, Colin Philip Leslie, Alessandra Pasquarello, Anna Sava, Luca G. Moccia, Barbara Bertani, Roberto Arban, Daniele Donati, Enrica Granci, Valeria Zucchelli, Paolo Cavanni, Massimo Gianotti, Romano Di-Fabio
Publikováno v:
Journal of Medicinal Chemistry. 53:5827-5843
Bioisoteric replacement of the metabolically labile N-methyl amide group of a series of benzoxazinones with small heterocyclic rings has led to novel series of fused tricyclic benzoxazines which are potent 5-HT1A/B/D receptor antagonists with and wit
Autor:
Stephen P. Watson, Adelheid Roth, Anna Sava, Greg J. Osborne, David John Nash, Paloma Perez, Ben Powney, Corrado Corti, Magalie Rocheville, Paul W. Smith, Clive Leslie Branch, Federica Bianchi, Pier D’Alessandro, Emma Koppe, Maite de los Frailes, Jesús Ángel de la Fuente, Annarosa Ugolini, Dino Montanari, Stephen L. Garland
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:759-762
The optimisation of an HTS hit series (1) leading to the identification of structurally novel, selective, orally bioavailable mGluR2 positive modulators GSK1331258 and GSK1331268 is described. Structure-activity relationships, attenuation of dopamine
Publikováno v:
Neuroscience Letters. 313:37-40
The muscle nicotinic acetylcholine receptor (AChR) turns over at different rates depending on stage of synaptogenesis and innervation. Tyrosine phosphorylation modulates desensitization, interaction with cytoskeleton and lateral mobility in the membr