Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Anna, Rapacz"'
Autor:
Anna Rapacz, Marcin Jakubiec, Michał Abram, Jakub Jasiński, Karolina Chrzan, Małgorzata Góra, Anna Dziubina, Katarzyna Wójcik-Pszczoła, Paulina Koczurkiewicz-Adamczyk, Katarzyna Ciepiela, Elżbieta Pękala, Jolanta Obniska, Krzysztof Kamiński
Publikováno v:
Pharmaceuticals, Vol 17, Iss 11, p 1532 (2024)
Background/Objectives: To address the unmet clinical needs in the treatment of epilepsy and pain, the continued development of more effective and safer anticonvulsants and analgesics is still necessary. Therefore, herein we report synthesis and antis
Externí odkaz:
https://doaj.org/article/a251ba8d7a9a4016a31cb678d9a9dcad
Autor:
Małgorzata Góra, Anna Czopek, Anna Rapacz, Anna Gębska, Katarzyna Wójcik-Pszczoła, Elżbieta Pękala, Krzysztof Kamiński
Publikováno v:
Molecules, Vol 26, Iss 6, p 1564 (2021)
The new series of 3-(2-chlorophenyl)- and 3-(3-chlorophenyl)-pyrrolidine-2,5-dione-acetamide derivatives as potential anticonvulsant and analgesic agents was synthesized. The compounds obtained were evaluated in the following acute models of epilepsy
Externí odkaz:
https://doaj.org/article/b8bfc7b7119b4b75ad75ecaaafd0642e
Autor:
Gabriela Mazur, Katarzyna Pańczyk‐Straszak, Anna Rapacz, Jan Kiszela, Magdalena Smolik, Maciej Gawlik, Maria Walczak, Joanna Czekajewska, Celina Poloczek, Elżbieta Karczewska, Ewa Żesławska, Wojciech Nitek, Anna Niedbał, Joanna Leśniak, Katarzyna Ciapala, Katarzyna Pawlik, Joanna Mika, Anna M. Waszkielewicz
A series of ten aminoalkanol derivatives of 5-chloro-2- or 5-chloro-4-methylxanthone was synthetized and evaluated for anticonvulsant properties (MES test, mice, intraperitoneal) and compared with neurotoxicity rotarod test (NT, mice, i.p.). The best
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39f6147c433b318056421569db4f1592
https://ruj.uj.edu.pl/xmlui/handle/item/297624
https://ruj.uj.edu.pl/xmlui/handle/item/297624
Autor:
Michał, Abram, Marcin, Jakubiec, Katelyn, Reeb, Mary Hongying, Cheng, Robin, Gedschold, Anna, Rapacz, Szczepan, Mogilski, Katarzyna, Socała, Dorota, Nieoczym, Małgorzata, Szafarz, Gniewomir, Latacz, Bartłomiej, Szulczyk, Justyna, Kalinowska-Tłuścik, Kinga, Gawel, Camila V, Esguerra, Elżbieta, Wyska, Christa E, Müller, Ivet, Bahar, Andréia C K, Fontana, Piotr, Wlaź, Rafał M, Kamiński, Krzysztof, Kamiński
Publikováno v:
Journal of medicinal chemistry. 65(17)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::338b23feb213a2d3ed90a9b7811d67f3
https://pubmed.ncbi.nlm.nih.gov/35984707
https://pubmed.ncbi.nlm.nih.gov/35984707
Autor:
Anna Rapacz, Jolanta Obniska, Anna Czopek, Elżbieta Pękala, Agnieszka Giza, Małgorzata Góra, Krzysztof Kamiński, Paulina Koczurkiewicz-Adamczyk
Publikováno v:
ChemMedChem. 16:1619-1630
The aim of this study was to design and synthesize two new series of pyrrolidine-2,5-dione-acetamides with a benzhydryl or sec-butyl group at position 3 as potential anticonvulsants. Their anticonvulsant activity was evaluated in standard animal mode
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6f77883e00108c30b7d104546d12f32
https://doi.org/10.1002/cmdc.202001007
https://doi.org/10.1002/cmdc.202001007
Autor:
Michał Abram, Kamil Kuś, Szczepan Mogilski, Karolina Matyjaszczyk, Krzysztof Kamiński, Anna Rapacz, Bartłomiej Szulczyk, Maria Walczak, Rafał M. Kamiński, Gniewomir Latacz
Publikováno v:
Epilepsia. 61:2119-2128
Objective The main objective of the present work was to assess the utility of KA-104 as potential therapy for drug-resistant seizures and neuropathic pain, and to characterize its druglike properties in a series of absorption, distribution, metabolis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55f18909a3f37e2768c466c3216b2569
https://doi.org/10.1111/epi.16669
https://doi.org/10.1111/epi.16669
Autor:
Tomasz Janowski, Małgorzata Chmielewska-Krzesińska, Marta J. Siemieniuch, Mark Leonard, Anna Rapacz-Leonard
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports
Scientific Reports
Despite their importance in mammalian reproduction, substances in the oxytocin-prostaglandins pathways have not been investigated in the horse placenta during most of pregnancy and parturition. Therefore, we quantified placental content of oxytocin (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1f651a1a13ebe72ab943ea19c593110
http://link.springer.com/article/10.1038/s41598-020-59085-1
http://link.springer.com/article/10.1038/s41598-020-59085-1
Autor:
Anna Waszkielewicz, Henryk Marona, Katarzyna Pańczyk-Straszak, Barbara Filipek, Anna Rapacz, Kinga Sałat, Monika Kubacka, Agnieszka Cios, Filip Fedak, Maria Walczak, Urszula Hubicka, Anna Kwiecień, Barbara Żuromska-Witek, Przemysław W. Szafrański, Paulina Koczurkiewicz-Adamczyk, Elżbieta Pękala, Katarzyna Przejczowska-Pomierny, Krzysztof Pociecha, Elżbieta Wyska
Publikováno v:
Pharmacological reports : PR.
Background Epilepsy frequently coexists with neuropathic pain. Our approach is based on the search for active compounds with multitarget profiles beneficial in terms of potential side effects and on the implementation of screening for potential multi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3debb8da197d60d8a1a7ddd592c44ea7
https://pubmed.ncbi.nlm.nih.gov/36401763
https://pubmed.ncbi.nlm.nih.gov/36401763
Autor:
Anna Dziubina, Anna Rapacz, Anna Czopek, Małgorzata Góra, Jolanta Obniska, Krzysztof Kamiński
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 7; Pages: 4057
Antiseizure drugs (ASDs) are commonly used to treat a wide range of nonepileptic conditions, including pain. In this context, the analgesic effect of four pyrrolidine-2,5-dione derivatives (compounds 3, 4, 6, and 9), with previously confirmed anticon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ddb7750089e86bb824d9bd7a7d678d2
https://pubmed.ncbi.nlm.nih.gov/35409413
https://pubmed.ncbi.nlm.nih.gov/35409413
Autor:
Katarzyna Pańczyk‐Straszak, Anna Rapacz, Henryk Marona, Dorota Żelaszczyk, Elżbieta Karczewska, Martyna Zając, Iwona Skiba‐Kurek, Agata Siwek, Anna Waszkielewicz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::203ae9fbad04d3c0a633111725399d05
https://ruj.uj.edu.pl/xmlui/handle/item/292352
https://ruj.uj.edu.pl/xmlui/handle/item/292352