Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Anna, Rapacz"'
Autor:
Michał Abram, Marcin Jakubiec, Paulina Koczurkiewicz-Adamczyk, Agata Doroz-Płonka, Anna Rapacz, Krzysztof Kamiński
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 18, p 9861 (2024)
In our current study, we developed a focused series of original ((benzyloxy)benzyl)propanamide derivatives that demonstrated potent activity across in vivo mouse seizure models, specifically, maximal electroshock (MES) and 6 Hz (32 mA) seizures. Amon
Externí odkaz:
https://doaj.org/article/267ad09041614b4a9618339345e9330d
Autor:
Szymon Jarzyński, Anna Rapacz, Anna Dziubina, Elżbieta Pękala, Justyna Popiół, Kamil Piska, Sławomir Wojtulewski, Bogna Rudolf
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 168, Iss , Pp 115749- (2023)
A series of 3-aminopyrrolidine-2,5-dione derivatives was synthesized and tested for anticonvulsant activity. Succinimide derivatives were obtained from a simple solvent-based reaction and a mechanochemical aza-Michael reaction of maleimide or its N-s
Externí odkaz:
https://doaj.org/article/6ade5abd629141e6b00a008358a95f9b
Autor:
Anna Dziubina, Anna Rapacz, Anna Czopek, Małgorzata Góra, Jolanta Obniska, Krzysztof Kamiński
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 7, p 4057 (2022)
Antiseizure drugs (ASDs) are commonly used to treat a wide range of nonepileptic conditions, including pain. In this context, the analgesic effect of four pyrrolidine-2,5-dione derivatives (compounds 3, 4, 6, and 9), with previously confirmed anticon
Externí odkaz:
https://doaj.org/article/2ef71e6af13048d090fb1a4946301d4f
Autor:
Michał Abram, Marcin Jakubiec, Anna Rapacz, Szczepan Mogilski, Gniewomir Latacz, Bartłomiej Szulczyk, Małgorzata Szafarz, Katarzyna Socała, Dorota Nieoczym, Elżbieta Wyska, Piotr Wlaź, Rafał M. Kamiński, Krzysztof Kamiński
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 23, p 13092 (2021)
We report herein a series of water-soluble analogues of previously described anticonvulsants and their detailed in vivo and in vitro characterization. The majority of these compounds demonstrated broad-spectrum anticonvulsant properties in animal sei
Externí odkaz:
https://doaj.org/article/a1a273109e184c6a9330b827ad6cea4d
Autor:
Małgorzata Góra, Anna Czopek, Anna Rapacz, Anna Gębska, Katarzyna Wójcik-Pszczoła, Elżbieta Pękala, Krzysztof Kamiński
Publikováno v:
Molecules, Vol 26, Iss 6, p 1564 (2021)
The new series of 3-(2-chlorophenyl)- and 3-(3-chlorophenyl)-pyrrolidine-2,5-dione-acetamide derivatives as potential anticonvulsant and analgesic agents was synthesized. The compounds obtained were evaluated in the following acute models of epilepsy
Externí odkaz:
https://doaj.org/article/b8bfc7b7119b4b75ad75ecaaafd0642e
Autor:
Michał Abram, Marcin Jakubiec, Anna Rapacz, Szczepan Mogilski, Gniewomir Latacz, Rafał M. Kamiński, Krzysztof Kamiński
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 22, p 8780 (2020)
Epilepsy belongs to the most common and debilitating neurological disorders with multifactorial pathophysiology and a high level of drug resistance. Therefore, with the aim of searching for new, more effective, and/or safer therapeutics, we discovere
Externí odkaz:
https://doaj.org/article/03681429a411417a8f3d66ee013102ba
Autor:
Gabriela Mazur, Katarzyna Pańczyk‐Straszak, Anna Rapacz, Jan Kiszela, Magdalena Smolik, Maciej Gawlik, Maria Walczak, Joanna Czekajewska, Celina Poloczek, Elżbieta Karczewska, Ewa Żesławska, Wojciech Nitek, Anna Niedbał, Joanna Leśniak, Katarzyna Ciapala, Katarzyna Pawlik, Joanna Mika, Anna M. Waszkielewicz
A series of ten aminoalkanol derivatives of 5-chloro-2- or 5-chloro-4-methylxanthone was synthetized and evaluated for anticonvulsant properties (MES test, mice, intraperitoneal) and compared with neurotoxicity rotarod test (NT, mice, i.p.). The best
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39f6147c433b318056421569db4f1592
https://ruj.uj.edu.pl/xmlui/handle/item/297624
https://ruj.uj.edu.pl/xmlui/handle/item/297624
Autor:
Małgorzata Góra, Anna Czopek, Anna Rapacz, Anna Dziubina, Monika Głuch-Lutwin, Barbara Mordyl, Jolanta Obniska
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 16, p 5750 (2020)
The present study aimed to design and synthesize a new series of hybrid compounds with pyrrolidine-2,5-dione and thiophene rings in the structure as potential anticonvulsant and antinociceptive agents. For this purpose, we obtained a series of new co
Externí odkaz:
https://doaj.org/article/142b1c1bc761482db07de7047397e7ae
Autor:
Michał, Abram, Marcin, Jakubiec, Katelyn, Reeb, Mary Hongying, Cheng, Robin, Gedschold, Anna, Rapacz, Szczepan, Mogilski, Katarzyna, Socała, Dorota, Nieoczym, Małgorzata, Szafarz, Gniewomir, Latacz, Bartłomiej, Szulczyk, Justyna, Kalinowska-Tłuścik, Kinga, Gawel, Camila V, Esguerra, Elżbieta, Wyska, Christa E, Müller, Ivet, Bahar, Andréia C K, Fontana, Piotr, Wlaź, Rafał M, Kamiński, Krzysztof, Kamiński
Publikováno v:
Journal of medicinal chemistry. 65(17)
Autor:
Anna Rapacz, Jolanta Obniska, Anna Czopek, Elżbieta Pękala, Agnieszka Giza, Małgorzata Góra, Krzysztof Kamiński, Paulina Koczurkiewicz-Adamczyk
Publikováno v:
ChemMedChem. 16:1619-1630
The aim of this study was to design and synthesize two new series of pyrrolidine-2,5-dione-acetamides with a benzhydryl or sec-butyl group at position 3 as potential anticonvulsants. Their anticonvulsant activity was evaluated in standard animal mode