Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Anna, Proschak"'
Autor:
Marco J. Rotter, Sabrina Zentgraf, Lilia Weizel, Denia Frank, Luisa D. Burgers, Steffen Brunst, Robert Fürst, Anna Proschak, Thomas A. Wichelhaus, Ewgenij Proschak
Publikováno v:
Molecules, Vol 28, Iss 4, p 1984 (2023)
Metallo beta lactamases (MBLs) are among the most problematic resistance mechanisms of multidrug-resistant Gram-negative pathogens due to their broad substrate spectrum and lack of approved inhibitors. In this study, we propose the integration of cat
Externí odkaz:
https://doaj.org/article/07a6b9920e1345b4853cd0c20978c4c0
Autor:
Ewgenij Proschak, Anna Proschak, Darina Barkhatova, Igor Solovyev, Thomas A. Wichelhaus, Dmitry Dar'in, Mikhail Krasavin, Steffen Brunst, Denia Frank, Lilia Weizel, Jan S. Kramer, Marco Rotter, Daniil Zhukovsky, Giada Martinelli
Publikováno v:
ChemMedChem. 16:3410-3417
Diversity-oriented synthesis (DOS) is a rich source for novel lead structures in Medicinal Chemistry. In this study, we present a DOS-compatible method for synthesis of compounds bearing a free thiol moiety. The procedure relies on Rh(II)-catalyzed c
Autor:
Mikhail, Krasavin, Daniil, Zhukovsky, Igor, Solovyev, Darina, Barkhatova, Dmitry, Dar'in, Denia, Frank, Giada, Martinelli, Lilia, Weizel, Anna, Proschak, Marco, Rotter, Jan S, Kramer, Steffen, Brunst, Thomas A, Wichelhaus, Ewgenij, Proschak
Publikováno v:
ChemMedChem. 16(22)
Diversity-oriented synthesis (DOS) is a rich source for novel lead structures in Medicinal Chemistry. In this study, we present a DOS-compatible method for synthesis of compounds bearing a free thiol moiety. The procedure relies on Rh(II)-catalyzed c
Autor:
Whitney Kilu, Ewgenij Proschak, Victor Hernandez-Olmos, Carmen Borkowsky, Astrid Kaiser, Roxane-I Kestner, Jan S. Kramer, Tamara Göbel, Sabine Willems, Stefan Knapp, Steffen Brunst, Jan Heering, Moritz Helmstädter, Dmitry Namgaladze, Xiaomin Ni, Waltraud Pfeilschifter, Mirko Brodsky, Anna Proschak, Dieter Steinhilber, Felix F Lillich, Franziska Mayser, Apirat Chaikuad, Lilia Weizel, Astrid S. Kahnt, Simone Schierle, Daniel Merk
Polypharmaceutical regimens often impair treatment of patients with metabolic syndrome (MetS), a complex disease cluster, including obesity, hypertension, heart disease, and type II diabetes. Simultaneous targeting of soluble epoxide hydrolase (sEH)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd7965bf06d6eedeb26c626933e27549
https://publica.fraunhofer.de/handle/publica/415873
https://publica.fraunhofer.de/handle/publica/415873
Autor:
Anna Proschak, Denia Frank, Steffen Brunst, Izidor Sosič, Thomas A. Wichelhaus, Stanislav Gobec, Robert Fürst, Luisa D. Burgers, Ewgenij Proschak, Marco Rotter, Giada Martinelli, Lilia Weizel
Publikováno v:
European journal of medicinal chemistry, str. 1-10 : Ilustr., Vol. 228, 2022
COBISS-ID: 25429760
COBISS-ID: 25429760
Carbapenemases such as metallo-[beta]-lactamases (MBLs) are spreading among Gram-negative bacterial pathogens. Infections due to these multidrug-resistant bacteria constitute a major global health challenge. Therapeutic strategies against carbapenema
Autor:
Moritz Helmstädter, Pascal Heitel, Ewgenij Proschak, Daniel Merk, Anna Proschak, Victor Hernandez-Olmos, Astrid Kaiser, Jurema Schmidt, Maximiliane Horz, Markus Hartmann, Simone Schierle, Lilia Weizel
Publikováno v:
Chemmedchem
The nuclear farnesoid X receptor (FXR) and the enzyme soluble epoxide hydrolase (sEH) are validated molecular targets to treat metabolic disorders such as non‐alcoholic steatohepatitis (NASH). Their simultaneous modulation in vivo has demonstrated
Autor:
Daniil Zhukovsky, Giada Martinelli, Jan S. Kramer, Denia Frank, Thomas A. Wichelhaus, Dmitry Dar'in, Marco Rotter, Anna Proschak, Lilia Weizel, Mikhail Krasavin, Ewgenij Proschak, Darina Barkhatova, Steffen Brunst, Igor Solovyev
Publikováno v:
ChemMedChem. 16:3375-3375
Autor:
Kirstin Scherlach, Antonietta Rossi, Anna Proschak, Jan Dworschak, Jan S. Kramer, Axel A. Brakhage, Ewgenij Proschak, Stefanie König, Jana Gerstmeier, Simona Pace, Lidia Sautebin, Helmut Pein, Maria Straßburger, Oliver Werz, Christian Hertweck, Jesper Z. Haeggström, Erik Romp, Fabiana Troisi, Thorsten Heinekamp
The epidithiodioxopiperazine gliotoxin is a virulence factor of Aspergillus fumigatus, the most important airborne fungal pathogen of humans. Gliotoxin suppresses innate immunity in invasive aspergillosis, particularly by compromising neutrophils, bu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd6528c2aa839f6c8d92d97794389cd9
https://publica.fraunhofer.de/handle/publica/262299
https://publica.fraunhofer.de/handle/publica/262299
Autor:
Kerstin Hiesinger, Jan S. Kramer, Janosch Achenbach, Daniel Moser, Julia Weber, Sandra K. Wittmann, Christophe Morisseau, Carlo Angioni, Gerd Geisslinger, Astrid S. Kahnt, Astrid Kaiser, Anna Proschak, Dieter Steinhilber, Denys Pogoryelov, Karen Wagner, Bruce D. Hammock, Ewgenij Proschak
Publikováno v:
ACS Med Chem Lett
ACS medicinal chemistry letters, vol 10, iss 6
ACS medicinal chemistry letters, vol 10, iss 6
[Image: see text] Selective optimization of side activities is a valuable source of novel lead structures in drug discovery. In this study, a computer-aided approach was used to deorphanize the pleiotropic cholesterol-lowering effects of the beta-blo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17d0bd79212ad879a0f7127a657eeefd
https://publica.fraunhofer.de/handle/publica/258815
https://publica.fraunhofer.de/handle/publica/258815
Autor:
Stefanie, König, Simona, Pace, Helmut, Pein, Thorsten, Heinekamp, Jan, Kramer, Erik, Romp, Maria, Straßburger, Fabiana, Troisi, Anna, Proschak, Jan, Dworschak, Kirstin, Scherlach, Antonietta, Rossi, Lidia, Sautebin, Jesper Z, Haeggström, Christian, Hertweck, Axel A, Brakhage, Jana, Gerstmeier, Ewgenij, Proschak, Oliver, Werz
Publikováno v:
Cell chemical biology. 26(4)
The epidithiodioxopiperazine gliotoxin is a virulence factor of Aspergillus fumigatus, the most important airborne fungal pathogen of humans. Gliotoxin suppresses innate immunity in invasive aspergillosis, particularly by compromising neutrophils, bu