Výsledky vyhledávání

The

Autor: Jens, Meschede, Maria, Šadić, Nikolas, Furthmann, Tim, Miedema, Dominik A, Sehr, A Kathrin, Müller-Rischart, Verian, Bader, Lena A, Berlemann, Anna, Pilsl, Anita, Schlierf, Katalin, Barkovits, Barbara, Kachholz, Katrin, Rittinger, Fumiyo, Ikeda, Katrin, Marcus, Liliana, Schaefer, Jörg, Tatzelt, Konstanze F, Winklhofer

Publikováno v: Sci Signal

The parkin coregulated gene (PACRG), which encodes a protein of unknown function, shares a bi-directional promoter with parkin (PRKN), which encodes an E3 ubiquitin ligase. Because PRKN is important in mitochondrial quality control and protection aga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2137f29a64d34864cbaa1fc479e9510d
https://pubmed.ncbi.nlm.nih.gov/32019898

Zobrazit plný text záznamu

The parkin-coregulated gene product PACRG promotes TNF signaling by stabilizing LUBAC

Autor: Katalin Barkovits, Fumiyo Ikeda, Liliana Schaefer, Nikolas Furthmann, Anita Schlierf, Jens Meschede, Tim Miedema, Dominik A. Sehr, Anna Pilsl, Lena A. Berlemann, Jörg Tatzelt, Maria Šadić, Katrin Rittinger, Konstanze F. Winklhofer, Verian Bader, A. Kathrin Müller-Rischart, Barbara Kachholz, Katrin Marcus

Publikováno v: Science Signaling. 13

The Parkin-coregulated gene (PACRG), which encodes a protein of unknown function, shares a bidirectional promoter with Parkin (PRKN), which encodes an E3 ubiquitin ligase. Because PRKN is important in mitochondrial quality control and protection agai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::13c2d1ffca4c832da65a6cee8b0c3b36
https://doi.org/10.1126/scisignal.aav1256

Zobrazit plný text záznamu

Akademický článek

Parkin is protective against proteotoxic stress in a transgenic zebrafish model.

Autor: Mareike E Fett, Anna Pilsl, Dominik Paquet, Frauke van Bebber, Christian Haass, Jörg Tatzelt, Bettina Schmid, Konstanze F Winklhofer

Publikováno v: PLoS ONE, Vol 5, Iss 7, p e11783 (2010)

Mutations in the gene encoding the E3 ubiquitin ligase parkin (PARK2) are responsible for the majority of autosomal recessive parkinsonism. Similarly to other knockout mouse models of PD-associated genes, parkin knockout mice do not show a substantia

Externí odkaz: https://doaj.org/article/88d7d03040ee4968a2ef81a834585572

Zobrazit plný text záznamu

Aberrant Folding of Pathogenic Parkin Mutants

Autor: Konstanze F. Winklhofer, Anna Pilsl, Jörg Tatzelt, Iris H. Henn, Julia S. Schlehe, Kerstin Lämmermann, A. Kathrin Lutz, Katja Grgur

Publikováno v: Journal of Biological Chemistry. 283:13771-13779

Loss-of-function mutations in the Parkin gene (PARK2) are responsible for the majority of autosomal recessive Parkinson disease. A growing body of evidence indicates that misfolding and aggregation of Parkin is a major mechanism of Parkin inactivatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c6f790f347ee4e2f42f61f7ee98a568e
https://doi.org/10.1074/jbc.m707494200

Zobrazit plný text záznamu

The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO

Publikováno v: Mol Cell
Molecular cell 49(5), 908-921 (2013). doi:10.1016/j.molcel.2013.01.036
Mol. Cell 49, 908-921 (2013)

Parkin, a RING-between-RING-type E3 ubiquitin ligase associated with Parkinson's disease, has a wide neuroprotective activity, preventing cell death in various stress paradigms. We identified a stress-protective pathway regulated by parkin that links

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f741d75d3bc8ba3566b658fa6f4fc23e
https://hdl.handle.net/21.11116/0000-000B-7ABD-8

Zobrazit plný text záznamu

Parkin, PINK1 and mitochondrial integrity: emerging concepts of mitochondrial dysfunction in Parkinson's disease

Autor: Anna Pilsl, Konstanze F. Winklhofer

Publikováno v: Acta neuropathologica 123(2), 173-188 (2011). doi:10.1007/s00401-011-0902-3

Mitochondria are dynamic organelles which are essential for many cellular processes, such as ATP production by oxidative phosphorylation, lipid metabolism, assembly of iron sulfur clusters, regulation of calcium homeostasis, and cell death pathways.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb5f7a6d2402ca1e2cf25fda82d46e0a

Zobrazit plný text záznamu

Parkin Is Protective against Proteotoxic Stress in a Transgenic Zebrafish Model

Autor: Frauke van Bebber, Dominik Paquet, Konstanze F. Winklhofer, Mareike E. Fett, Bettina Schmid, Anna Pilsl, Jörg Tatzelt, Christian Haass

Publikováno v: PLoS ONE
PLoS ONE, Vol 5, Iss 7, p e11783 (2010)
PLOS ONE 5(7), e11783 (2010). doi:10.1371/journal.pone.0011783

Background: Mutations in the gene encoding the E3 ubiquitin ligase parkin (PARK2) are responsible for the majority of autosomal recessive parkinsonism. Similarly to other knockout mouse models of PD-associated genes, parkin knockout mice do not show

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::084c36717818261c3b1f654ccfe22804
http://europepmc.org/articles/PMC2912770

Zobrazit plný text záznamu

Parkinson's disease-associated genes and mitochondrial integrity

Autor: A. Kathrin Lutz, Konstanze F. Winklhofer, Anna Pilsl, Jörg Tatzelt, Lena Bouman

Publikováno v: Biochimica et biophysica acta / Bioenergetics 1797, 75 (2010). doi:10.1016/j.bbabio.2010.04.229
European Bioenergetics Conference
Biochimica et biophysica acta / Bioenergetics 1797, 75 (2010).
16th European Bioenergetics Conference, 2010-07-17-2010-07-22

Parkinson's disease (PD) is the most common movement disorder and the second most common neurodegenerative disease after Alzheimer's disease, affecting an increasing number of patients due to the demographic trend towards an aged population. Oxidativ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23480c3cad1c3fc594245fb39d1fc51f
https://pub.dzne.de/record/165098

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání