Zobrazeno 1 - 10
of 112
pro vyhledávání: '"Anna, Philpott"'
Autor:
Revathy Ramachandran, Shakhzada Ibragimova, Laura M. Woods, Tamader AlHouqani, Roshna Lawrence Gomez, Fabrizio Simeoni, Mahmood Y. Hachim, Tim C.P. Somervaille, Anna Philpott, Jason S. Carroll, Fahad R. Ali
Publikováno v:
iScience, Vol 27, Iss 8, Pp 110500- (2024)
Summary: Triple-negative breast cancer (TNBC) is characterized by lack of the estrogen (ER) receptor, progesterone receptor (PR), and human epidermal growth factor receptor-2 (HER2), and standard receptor-targeted therapies are ineffective. FOXC1, a
Externí odkaz:
https://doaj.org/article/95f276360fa1442aa803bad570a00ca8
Elevated ASCL1 activity creates de novo regulatory elements associated with neuronal differentiation
Autor:
Laura M. Woods, Fahad R. Ali, Roshna Gomez, Igor Chernukhin, Daniel Marcos, Lydia M. Parkinson, Ahmad N. Abou Tayoun, Jason S. Carroll, Anna Philpott
Publikováno v:
BMC Genomics, Vol 23, Iss 1, Pp 1-15 (2022)
Abstract Background The pro-neural transcription factor ASCL1 is a master regulator of neurogenesis and a key factor necessary for the reprogramming of permissive cell types to neurons. Endogenously, ASCL1 expression is often associated with neurobla
Externí odkaz:
https://doaj.org/article/89eed2ceb61f4f35ab523721e0a30e0a
Autor:
Roberta Azzarelli, Aoibheann McNally, Claudia Dell’Amico, Marco Onorati, Benjamin Simons, Anna Philpott
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract The growth of glioblastoma (GBM), one of the deadliest adult cancers, is fuelled by a subpopulation of stem/progenitor cells, which are thought to be the source of resistance and relapse after treatment. Re-engagement of a latent capacity of
Externí odkaz:
https://doaj.org/article/3a17aa5949194929914e94610039108c
Autor:
Lydia M. Parkinson, Sarah L. Gillen, Laura M. Woods, Lewis Chaytor, Daniel Marcos, Fahad R. Ali, Jason S. Carroll, Anna Philpott
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Neuroblastoma is believed to arise from sympathetic neuroblast precursors that fail to engage the neuronal differentiation programme, but instead become locked in a pro-proliferative developmental state. Achaete-scute homolog 1 (ASCL1) is a proneural
Externí odkaz:
https://doaj.org/article/86959bc2c5464a4c828c6b43b05a923a
Autor:
Roshna Lawrence Gomez, Laura M. Woods, Revathy Ramachandran, Ahmad N. Abou Tayoun, Anna Philpott, Fahad R. Ali
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Neuroblastoma is a pediatric tumour that accounts for more than 15% of cancer-related deaths in children. High-risk tumours are often difficult to treat, and patients’ survival chances are less than 50%. Retinoic acid treatment is part of the maint
Externí odkaz:
https://doaj.org/article/388d8674c43942e7bdb8e70674963ce6
Autor:
Magdalena K. Sznurkowska, Edouard Hannezo, Roberta Azzarelli, Lemonia Chatzeli, Tatsuro Ikeda, Shosei Yoshida, Anna Philpott, Benjamin D. Simons
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
The cellular basis of islet morphogenesis and fate allocation remain unclear. Here, the authors use a R26-CreER-R26R-Confetti mouse line to follow quantitatively the clonal dynamics of islet formation showing how, during the secondary transition, isl
Externí odkaz:
https://doaj.org/article/2516bc6a95c0469cbc1e4e1c8a53f059
Publikováno v:
Biology Open, Vol 10, Iss 2 (2021)
Emerging three-dimensional (3D) cultures of glioblastoma are becoming powerful models to study glioblastoma stem cell behavior and the impact of cell–cell and cell–microenvironment interactions on tumor growth and invasion. Here we describe a met
Externí odkaz:
https://doaj.org/article/79a7a530a9274bcc9ff57f7b7f97a722
Autor:
Laura J. A. Hardwick, Anna Philpott
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
The use of the Xenopus model system has provided diverse contributions to cancer research, not least because of the striking parallels between tumour pathogenesis and early embryo development. Cell cycle regulation, signalling pathways, and cell beha
Externí odkaz:
https://doaj.org/article/782930d5a8e94996a327f373736ee9cf
Autor:
Laura J.A. Hardwick, Anna Philpott
Publikováno v:
Wellcome Open Research, Vol 3 (2018)
From the relatively simple nervous system of Drosophila to the elaborate mammalian cortex, neurogenesis requires exceptional spatial and temporal precision to co-ordinate progenitor cell proliferation and subsequent differentiation to a diverse range
Externí odkaz:
https://doaj.org/article/8dba979261d54d44bc081e2c397a012a
Autor:
Laura J.A. Hardwick, Anna Philpott
Publikováno v:
Wellcome Open Research, Vol 3 (2018)
The proneural basic-helix-loop-helix (bHLH) transcription factor Ascl1 is a master regulator of neurogenesis in both central and peripheral nervous systems in vivo, and is a central driver of neuronal reprogramming in vitro. Over the last three decad
Externí odkaz:
https://doaj.org/article/8a657d528b8a41128767d37808f12956