Výsledky vyhledávání

Akademický článek

Neoadjuvant sunitinib plus exemestane in post-menopausal women with hormone receptor-positive/HER2-negative early-stage breast cancer (SUT_EXE-08): a phase I/II trial

Autor: Bartomeu Fullana, Serafín Morales, Anna Petit, Ania Alay, Helena Verdaguer, Fina Climent, Valentí Navarro-Perez, Mónica Cejuela, Patricia Galvan, Anna Gumà, Antonio Llombart-Cussac, David Cordero, Oriol Casanovas, Aleix Prat, Miguel Gil-Gil, Sonia Pernas

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-8 (2024)

Abstract Neoadjuvant endocrine therapy (NET) for hormone receptor-positive (HR+) breast cancer might be as effective as chemotherapy, with a better toxicity profile. Blocking a crucial process such as angiogenesis with sunitinib may have a synergisti

Externí odkaz: https://doaj.org/article/73d2bd5e8b3149adab539c333f43a859

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

An interdisciplinary framework for navigating social–climatic tipping points

Autor: Sonia Graham, Melanie Wary, Fulvia Calcagni, Mercè Cisneros, Claudia deLuca, Santiago Gorostiza, Ola Stedje Hanserud, Giorgos Kallis, Panagiota Kotsila, Sina Leipold, Jagoba Malumbres‐Olarte, Tristan Partridge, Anna Petit‐Boix, Anke Schaffartzik, Galia Shokry, Sergio Tirado‐Herrero, Jeroen van denBergh, Patrizia Ziveri

Publikováno v: People and Nature, Vol 5, Iss 5, Pp 1445-1456 (2023)

Abstract To effectively navigate out of the climate crisis, a new interdisciplinary approach is needed to guide and facilitate research that integrates diverse understandings of how transitions evolve in intertwined social–environmental systems. Th

Externí odkaz: https://doaj.org/article/2fe64e22dcba4ea49e919c2cb17de8cc

Zobrazit plný text záznamu

Akademický článek

RANK is a poor prognosis marker and a therapeutic target in ER‐negative postmenopausal breast cancer

Publikováno v: EMBO Molecular Medicine, Vol 15, Iss 4, Pp 1-12 (2023)

Abstract Despite strong preclinical data, the therapeutic benefit of the RANKL inhibitor, denosumab, in breast cancer patients, beyond the bone, is unclear. Aiming to select patients who may benefit from denosumab, we hereby analyzed RANK and RANKL p

Externí odkaz: https://doaj.org/article/1a7e932a6a184ce6a384d4a58e43a0be

Zobrazit plný text záznamu

Akademický článek

Axillary lymph node dissection versus radiotherapy in breast cancer with positive sentinel nodes after neoadjuvant therapy (ADARNAT trial)

Publikováno v: Frontiers in Oncology, Vol 13 (2023)

IntroductionBreast cancer surgery currently focuses on de-escalating treatment without compromising patient survival. Axillary radiotherapy (ART) now replaces axillary lymph node dissection (ALND) in patients with limited sentinel lymph node (SLN) in

Externí odkaz: https://doaj.org/article/30ba8ac951094fa79ebceba7d19bfada

Zobrazit plný text záznamu

Akademický článek

Diagnostic problems in high-risk breast lesions

Autor: Monsó, Maria Teresa Soler, Llauradó, Andrea Feu, Montserrat, Anna Petit, Azcárate, Juan, Vicente, Maria, Espejo-Herrera, Nadia

Publikováno v: In Revista de Senología y Patología Mamaria July 2022 35 Supplement 2:S32-S42

Zobrazit plný text záznamu

Akademický článek

Modification of BRCA1-associated breast cancer risk by HMMR overexpression

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)

The effect of hyaluronan-mediated motility receptor (HMMR) expression in BRCA1-associated breast cancer risk remains unknown. Here, HMMR overexpression induces the activation of cGAS-STING and non-canonical NF-κB signalling, instigating an immune pe

Externí odkaz: https://doaj.org/article/63fe713cc69c441fb5f6ed1eab75272b

Zobrazit plný text záznamu

Akademický článek

Matrix Metalloproteinase-9 Expression Is Associated with the Absence of Response to Neoadjuvant Chemotherapy in Triple-Negative Breast Cancer Patients

Publikováno v: International Journal of Molecular Sciences, Vol 24, Iss 14, p 11297 (2023)

Triple-negative breast cancer (TNBC) is particularly challenging due to the weak or absent response to therapeutics and its poor prognosis. The effectiveness of neoadjuvant chemotherapy (NAC) response is strongly influenced by changes in elements of

Externí odkaz: https://doaj.org/article/40a49007d77a46ec90ea3548ccfa343a

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

RANK signaling increases after anti-HER2 therapy contributing to the emergence of resistance in HER2-positive breast cancer

Publikováno v: Breast Cancer Research, Vol 23, Iss 1, Pp 1-18 (2021)

Abstract Background Around 15–20% of primary breast cancers are characterized by HER2 protein overexpression and/or HER2 gene amplification. Despite the successful development of anti-HER2 drugs, intrinsic and acquired resistance represents a major

Externí odkaz: https://doaj.org/article/30beb90cbbc444768fc569001a4484a0

Zobrazit plný text záznamu

Akademický článek

Assessment of Tumor Cell Death After Percutaneous Ultrasound– Guided Radiofrequency Ablation of Breast Carcinoma: A Prospective Study

Autor: Anna Guma, Teresa Soler, César G. Chappuis, Alazne Valdivielso, Anna Petit, Maria J. Pla, Catalina Falo, Sònia Pernas, Raúl Ortega, María Vicente, Laia Pérez, Eulalia Fernandez-Montoli, Miriam Campos, Fernando Burdio, Jordi Ponce, Nahum Calvo, Amparo Garcia-Tejedor

Publikováno v: Archives of Breast Cancer (2021)

Background: Current trends in breast cancer treatment include the use of less aggressive surgeries to reduce morbidity, shorten hospital stays and improve cosmetic results. The aim of the study is to assess tumor cell viability after percutaneous ult

Externí odkaz: https://doaj.org/article/970e8a72721e4142b645183d1e4b0ae2

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání