Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Anna, Ollerstam"'
Autor:
Stefan Eirefelt, Martin Stahlhut, Naila Svitacheva, Martin A. Carnerup, Joel Mauricio Correa Da Rosa, David Adrian Ewald, Troels T. Marstrand, Mikkel Krogh-Madsen, Georg Dünstl, Kevin Neil Dack, Anna Ollerstam, Hanne Norsgaard
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Glucocorticoids (GCs) are commonly used topical treatments for skin diseases but are associated with both local and systemic side effects. In this study, we describe a selective non-steroidal glucocorticoid receptor (GR) agonist for topical
Externí odkaz:
https://doaj.org/article/cfd4a2be093d473793d9d6101bfebe75
Autor:
Thomas Vifian, Tatiana G Stilou, Simon Feldbaek Nielsen, Maja Lambert, Jens Christian Højland Larsen, Tine Skak-Nielsen, Anders Soehoel, Pontus Hegardt, Lene M. Hansen, Nina Østergaard Knudsen, Morten Dahl Sørensen, Mogens Larsen, Cecilia Eskilsson, Steen Laursen, Stefan Eirefelt, Henrik Pettersson, Anna Ollerstam
Publikováno v:
Journal of Medicinal Chemistry. 63:14502-14521
We describe the design of a novel PDE4 scaffold and the exploration of the dual-soft concept to reduce systemic side effects via rapid elimination: introducing ester functionalities that can be inactivated in blood as well as by the liver (dual-soft)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1fb38d7abc4b9986a9e38e75c9c4ae01
https://doi.org/10.1021/acs.jmedchem.0c00797
https://doi.org/10.1021/acs.jmedchem.0c00797
Autor:
Anna Ollerstam, Kinga Balogh Sivars, Catherine J. Betts, Linnea Särén, Guanghui Liu, Xiao-Hong Zhou, Helena Douglasson, Per M. Åberg
Publikováno v:
Archives of toxicology. 95(8)
Chronic inflammatory diseases of the respiratory tract, such as chronic obstructive pulmonary disease (COPD) and asthma, are severe lung diseases that require effective treatments. In search for new medicines for these diseases, there is an unmet nee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ba1d32279ad580f99e461bf439d86a3
https://pubmed.ncbi.nlm.nih.gov/34191076
https://pubmed.ncbi.nlm.nih.gov/34191076
Autor:
Jens, Larsen, Maja, Lambert, Henrik, Pettersson, Thomas, Vifian, Mogens, Larsen, Anna, Ollerstam, Pontus, Hegardt, Cecilia, Eskilsson, Steen, Laursen, Anders, Soehoel, Tine, Skak-Nielsen, Lene M, Hansen, Nina Ø, Knudsen, Stefan, Eirefelt, Morten D, Sørensen, Tatiana G, Stilou, Simon F, Nielsen
Publikováno v:
Journal of medicinal chemistry. 63(23)
We describe the design of a novel PDE4 scaffold and the exploration of the dual-soft concept to reduce systemic side effects via rapid elimination: introducing ester functionalities that can be inactivated in blood as well as by the liver (dual-soft)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::91d778dd5cf2a7a2234d7f9358d53149
https://pubmed.ncbi.nlm.nih.gov/33054196
https://pubmed.ncbi.nlm.nih.gov/33054196
Autor:
Anna Ollerstam, Krister Henriksson, Patrick Stephen Johnson, Martin A. Carnerup, Martin Stahlhut, Dack Kevin Neil, Stefan Eirefelt
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 30:127402
Steroidal glucocorticoids (GR agonists) have been widely used for the topical treatment of skin disorders, including atopic dermatitis. They are a very effective therapy, but they are associated with both unwanted local effects in the skin (skin thin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e52eddab6e415d6398be335db12327fd
https://doi.org/10.1016/j.bmcl.2020.127402
https://doi.org/10.1016/j.bmcl.2020.127402
Autor:
Anna H. Persson, Sandra A.G. Visser, Lars B. Nilsson, Tomas Forsberg, Johan Gabrielsson, Anna Ollerstam, Jan-Arne Björkman, Ahmad Al-Saffar, Göran Duker
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 56:131-144
Introduction: The aim of the present study was to compare sensitivity in detecting the drug-induced QT interval prolongation in three dog models: conscious telemetered at sinus rhythm and conscious and anesthetized dogs during atrial pacing. The test
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c4b2dc8c425cc9af7b025790a455bb1
https://doi.org/10.1016/j.vascn.2007.05.002
https://doi.org/10.1016/j.vascn.2007.05.002
Autor:
Lars B. Nilsson, Göran Eklund, Stig Johan Wiklund, Göran Duker, Ahmad Al-Saffar, Tomas Forsberg, Johan Gabrielsson, Anna H. Persson, Anna Ollerstam, J. Magnus Fredriksson, Sandra A.G. Visser
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 55:35-48
Introduction: Drug-induced QT interval prolongation may lead to ventricular arrhythmias. The aim of the study was to optimize QT interval data processing to quantify drug-induced QT interval prolongation in the telemetry instrumented conscious dog mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dea178a75325028559170c347f76cfad
https://doi.org/10.1016/j.vascn.2006.02.009
https://doi.org/10.1016/j.vascn.2006.02.009
Autor:
Anna Hårdemark, Peter Illes, Björn Johansson, Wolfgang Poelchen, Russell D. Brown, Cecilia Lövdahl, Zsuzsanna Wiesenfeld-Hallin, Catarina Johansson, Bertil B. Fredholm, Rosa M. Escorihuela, Nancy R. Zahniser, Samuel Gebre-Medhin, Anna Ollerstam, Lihong Diao, Shinichi Tokuno, Alberto Fernández-Teruel, Susan A. Masino, Peter Thorén, Eric Herlenius, Thomas V. Dunwiddie, Gunnar Schulte, Ole Skøtt, Linda Halldner, Xiao-Jun Xu, Hilchen Sommerschild, Lydia Giménez-Llort, Milos Pekny, A. Erik G. Persson, Guro Valen
Publikováno v:
Drug Development Research. 58:350-353
The second coding exon of the adenosine A, receptor gene was eliminated by homologous recombination. The phenotype of mice (mixed C57B6/129OlaHsd background) was studied, using siblings from matings of heterozygous mice. Among the offspring the ratio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e7d8a6c6ad38432307538dfb0ac47f4
https://doi.org/10.1002/ddr.10170
https://doi.org/10.1002/ddr.10170
Publikováno v:
Acta Physiologica Scandinavica. 176:245-252
The neuronal isoform of nitric oxide synthase (nNOS) in the kidney is predominantly located in the macula densa (MD) cells. These cells are known to be the sensor in the tubuloglomerular feedback, which influences the tonus of the afferent arteriole.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::768d187a4395e20a900f4bc7f05e921a
https://doi.org/10.1046/j.1365-201x.2002.01014.x
https://doi.org/10.1046/j.1365-201x.2002.01014.x
Publikováno v:
Acta Physiologica Scandinavica. 176:91-94
The tubuloglomerular feedback (TGF) mechanism is an important regulator of the glomerular filtration rate (GFR) and urine excretion rate. It operates by sensing the distal delivery of fluid at the macula densa site and adjusting the tone of the glome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19d328d14be8d15ab6ecb1a8ea8b1d55
https://doi.org/10.1046/j.1365-201x.2002.01026.x
https://doi.org/10.1046/j.1365-201x.2002.01026.x