Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Anna, Mero"'
Autor:
Hiroki Yoshioka, Antonella Grigoletto, Gianfranco Pasut, Antonio Rosato, Katia Maso, Anna Mero
Publikováno v:
Polymer Chemistry. 7:6545-6553
Microbial transglutaminase (mTGase) is an enzyme that catalyzes site-specific protein derivatization at specific glutamines. mTGase-mediated conjugation with PEG-NH2 to granulocyte colony stimulating factor (G-CSF) yields a site selective mono-deriva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f4d296e9422098f8c3e3324e7c0f4a7
https://doi.org/10.1039/c6py01616b
https://doi.org/10.1039/c6py01616b
Publikováno v:
Macromolecular Bioscience. 16:50-56
The use of therapeutic proteins is often impaired by their short in vivo half-lives. PEGylation has been exploited to enhance protein stability and to prolong the pharmacokinetic. The biophysical characterization of two site-specific mono-PEGylated f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e406bd9b2d6f9edaffaf2f6c57357a9f
https://doi.org/10.1002/mabi.201500282
https://doi.org/10.1002/mabi.201500282
Publikováno v:
Journal of drug targeting. 25(9-10)
Microbial transglutaminase enzyme (mTGase) is an extremely useful enzyme that is increasingly employed in the food and pharmaceutical industries and as a tool for protein modification and tagging. The current study describes how we immobilised mTGase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50cbdd808ba8a8e51f58df0be3a4a88c
https://pubmed.ncbi.nlm.nih.gov/28805084
https://pubmed.ncbi.nlm.nih.gov/28805084
Publikováno v:
Methods in enzymology. 590
PEGylation, the covalent attachment of polyethylene glycol to bioactive molecules, is one of the leading approaches used to prolong pharmacokinetics, to improve the stability, and to reduce the immunogenicity of therapeutic proteins. PEG-conjugated p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6f14cd02ee7a41835cdba9354a6687a5
https://pubmed.ncbi.nlm.nih.gov/28411643
https://pubmed.ncbi.nlm.nih.gov/28411643
PEGylation, the covalent attachment of polyethylene glycol to bioactive molecules, is one of the leading approaches used to prolong pharmacokinetics, to improve the stability, and to reduce the immunogenicity of therapeutic proteins. PEG-conjugated p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d556089de43496a07ff2bcc59bd1c8b0
http://hdl.handle.net/11577/3226289
http://hdl.handle.net/11577/3226289
Autor:
Cynthia Secchieri, Jean M. Dayer, Anna Mero, Marta Favero, Carlo Barbera, Steven R. Goldring, Mary B. Goldring, Gianfranco Pasut, Monica Campisi
Publikováno v:
Journal of Controlled Release. 187:30-38
Osteoarthritis (OA) is characterized by chronic degeneration of joints, involving mainly the articular cartilage and the underlying bone, and severely impairing the quality of life of the patient. Although with limited efficacy, currently available p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ebac550a548ff6f9b7ac5857c222705
https://doi.org/10.1016/j.jconrel.2014.05.008
https://doi.org/10.1016/j.jconrel.2014.05.008
Autor:
Monica Campisi, Anna Mero
Publikováno v:
Polymers, Vol 6, Iss 2, Pp 346-369 (2014)
Hyaluronic acid (HA) has currently several therapeutic applications: in ophthalmology, osteoarthritis, wound healing, tissue regeneration, postoperative anti-adhesion and anesthetic medicine. In the last ten years, it has also been successfully inves
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d6733668ce265180fdb264af51fadf5
http://www.mdpi.com/2073-4360/6/2/346
http://www.mdpi.com/2073-4360/6/2/346
Publikováno v:
Bioconjugate Chemistry. 24:456-463
Several strategies for site-specific PEGylation have been successfully exploited to conjugate poly(ethylene glycol) (PEG) to pharmaceutical proteins. The advantages sought are those of improving efficacy and increasing the half-life of conjugated pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcf3017d0df76a29667d727e89ec418e
https://doi.org/10.1021/bc300594y
https://doi.org/10.1021/bc300594y
Publikováno v:
Carbohydrate Polymers. 92:2163-2170
Polymer conjugation has been widely exploited to prolong half-life and reduce immunogenicity of therapeutic proteins. Here, the potentials of hyaluronic acid (HA) have been investigated by studying the conjugates with two model enzymes, trypsin and R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81b91e7fd7cc36b219a522078e72b7dc
https://doi.org/10.1016/j.carbpol.2012.11.090
https://doi.org/10.1016/j.carbpol.2012.11.090
Autor:
Isabella Monia Montagner, Antonio Rosato, Angelo Fontana, Antonella Grigoletto, Barbara Spolaore, Gianfranco Pasut, Samanta Raboni, Abhijeet Satwekar, Anna Mero
Interferon α (IFN α) subtypes are important protein drugs that have been used to treat infectious diseases and cancers. Here, we studied the reactivity of IFN α-2b to microbial transglutaminase (TGase) with the aim of obtaining a site-specific con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7f4b78f7a1494d2fc949aa4667ddd60
http://hdl.handle.net/11577/3217145
http://hdl.handle.net/11577/3217145