Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Anna, Lorenc"'
Autor:
Anne Eugster, Anna Lorenc, Martin Kotrulev, Yogesh Kamra, Manisha Goel, Katja Steinberg-Bains, Shereen Sabbah, Sevina Dietz, Ezio Bonifacio, Mark Peakman, Iria Gomez-Tourino
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Autoimmune diseases result from autoantigen-mediated activation of adaptive immunity; intriguingly, autoantigen-specific T cells are also present in healthy donors. An assessment of dynamic changes of this autoreactive repertoire in both hea
Externí odkaz:
https://doaj.org/article/232b3f7f7b544729b1e9d70d032e0c11
Publikováno v:
Pharmaceutics, Vol 16, Iss 1, p 15 (2023)
Neurotrophic keratopathy is a corneal disease characterized by impaired corneal innervation. It can lead to corneal epithelial defects, ulcerations, and perforations. Topical insulin has been shown to be effective in treating this disorder. Insulin i
Externí odkaz:
https://doaj.org/article/1be7d11409f2467893c6ef1cf50ac10e
Publikováno v:
Children, Vol 10, Iss 10, p 1643 (2023)
Background: Noonan syndrome (NS) represents a fairly common genetic disorder with a highly variable phenotype. Its features include inherited heart defects, characteristic facial features, short stature, and mild retardation of motor skills. Case pre
Externí odkaz:
https://doaj.org/article/aee2a4812238491b8e423bfe54c74f3e
Autor:
Lara Bossini-Castillo, Dafni A. Glinos, Natalia Kunowska, Gosia Golda, Abigail A. Lamikanra, Michaela Spitzer, Blagoje Soskic, Eddie Cano-Gamez, Deborah J. Smyth, Claire Cattermole, Kaur Alasoo, Alice Mann, Kousik Kundu, Anna Lorenc, Nicole Soranzo, Ian Dunham, David J. Roberts, Gosia Trynka
Publikováno v:
Cell Genomics, Vol 2, Iss 4, Pp 100117- (2022)
Summary: Identifying cellular functions dysregulated by disease-associated variants could implicate novel pathways for drug targeting or modulation in cell therapies. However, follow-up studies can be challenging if disease-relevant cell types are di
Externí odkaz:
https://doaj.org/article/50dd0eba6db04899b2d6d3d94c8d2b92
Autor:
Sefina Arif, Irma Pujol-Autonell, Yogesh Kamra, Evangelia Williams, Norkhairin Yusuf, Clara Domingo-Vila, Yasaman Shahrabi, Emily Pollock, Leena Khatri, Mark Peakman, Timothy Tree, Anna Lorenc
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
AimsRecent studies highlight the potentially important role of neoepitopes in breaking immune tolerance in type 1 diabetes. T cell reactivity to these neoepitopes has been reported, but how this response compares quantitatively and phenotypically wit
Externí odkaz:
https://doaj.org/article/f945964b44d541e4ba421761e7916752
Autor:
Agnieszka Klimek-Kopyra, Magdalena Bacior, Anna Lorenc-Kozik, Reinhard W. Neugschwandtner, Tadeusz Zając
Publikováno v:
Italian Journal of Agronomy (2020)
Phenotypic plasticity of agricultural plants is considered to be one of the main means by which plants cope with the variability of environmental factors. A major contributor to plant plasticity is sowing density, which has a relevant impact on compe
Externí odkaz:
https://doaj.org/article/b3aa500d1aac4969888037a077345ee6
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
T cell receptors are generated by somatic gene recombination, and are normally selected against autoreactivity. Here the authors show that CD4 T cells from patients with autoimmune type 1 diabetes have shorter TCRβ sequences, broader repertoire dive
Externí odkaz:
https://doaj.org/article/380b4cadc81944b194b1293a9b9b42f5
Autor:
Christina Hertel, Dmytro Fishman, Anna Lorenc, Annamari Ranki, Kai Krohn, Pärt Peterson, Kai Kisand, Adrian Hayday
Publikováno v:
eLife, Vol 8 (2019)
In 2016, we reported four substantial observations of APECED/APS1 patients, who are deficient in AIRE, a major regulator of central T cell tolerance (Meyer et al., 2016). Two of those observations have been challenged. Specifically, ‘private’ aut
Externí odkaz:
https://doaj.org/article/24fc7f424d1e48169ad3236076219093
Autor:
Blagoje Soskic, Eddie Cano-Gamez, Deborah J. Smyth, Kirsty Ambridge, Ziying Ke, Julie C. Matte, Lara Bossini-Castillo, Joanna Kaplanis, Lucia Ramirez-Navarro, Anna Lorenc, Nikolina Nakic, Jorge Esparza-Gordillo, Wendy Rowan, David Wille, David F. Tough, Paola G. Bronson, Gosia Trynka
Publikováno v:
Nature Genetics. 54:817-826
During activation, T cells undergo extensive gene expression changes that shape the properties of cells to exert their effector function. Understanding the regulation of this process could help explain how genetic variants predispose to immune diseas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7bf64c659c536992d40eac93d62444f0
https://doi.org/10.1038/s41588-022-01066-3
https://doi.org/10.1038/s41588-022-01066-3
Autor:
Yuk-Fun Liu, Jake Powrie, Sefina Arif, Jennie H.M. Yang, Evangelia Williams, Leena Khatri, Mamta Joshi, Loic Lhuillier, Nikolaos Fountoulakis, Emma Smith, Craig Beam, Anna Lorenc, Mark Peakman, Timothy Tree
Publikováno v:
Diabetes. 71:722-732
Type 1 diabetes is characterized by a loss of tolerance to pancreatic β-cell autoantigens and defects in T regulatory cell (Treg) function. In preclinical models, immunotherapy with MHC-selective, autoantigenic peptides restores immune tolerance, pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b87ccec177121a6e30a6f57724a088f
https://doi.org/10.2337/db21-0728
https://doi.org/10.2337/db21-0728