Priming of HIV-1-specific CD8+ T cells with strong functional properties from naïve T cells

Autor: Tomohiro Akahoshi, Victor Appay, Anna Lissina, Xiaoming Sun, Masafumi Takiguchi, Takuya Yamamoto, Nozomi Kuse

Publikováno v: EBioMedicine. 42:109-119

Background HIV-1-specific CD8+ T cells are required for immune suppression of HIV-1 replication and elimination of the associated viral reservoirs. However, effective induction of functional HIV-1-specific CD8+ T cells from naive cells remains proble

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a41143ce6385d28a68a08bcac18c7d26
https://doi.org/10.1016/j.ebiom.2019.03.078

The TLR9 ligand CpG ODN 2006 is a poor adjuvant for the induction of de novo CD8

Autor: Laura, Papagno, Nozomi, Kuse, Anna, Lissina, Emma, Gostick, David A, Price, Victor, Appay, Francesco, Nicoli

Publikováno v: Scientific Reports

Toll-like receptor 9 (TLR9) agonists have gained traction in recent years as potential adjuvants for the induction of adaptive immune responses. It has nonetheless remained unclear to what extent such ligands can facilitate the priming events that ge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c38a05f404cdd7dc4aa9c6f3b5ae556c
https://pubmed.ncbi.nlm.nih.gov/32669577

Divergent roles for antigenic drive in the aetiology of primary versus dasatinib-associated CD8+ TCR-Vβ+ expansions

Autor: Anna Lissina, James E. McLaren, Mette Ilander, Emma I. Andersson, Catherine S. Lewis, Mathew Clement, Andrew Herman, Kristin Ladell, Sian Llewellyn-Lacey, Kelly L. Miners, Emma Gostick, J. Joseph Melenhorst, A. John Barrett, David A. Price, Satu Mustjoki, Linda Wooldridge

Publikováno v: Lissina, A, McLaren, J E, Ilander, M, Andersson, E, Lewis, C S, Clement, M, Herman, A, Ladell, K, Llewellyn-Lacey, S, Miners, K, Gostick, E, Melenhorst, J J, Barrett, A J, Price, D A, Mustjoki, S & Wooldridge, L 2018, ' Divergent roles for antigenic drive in the aetiology of primary versus dasatinib-associated CD8+ TCR-Vβ+ expansions ', Scientific Reports, vol. 8, no. 1, 2534 . https://doi.org/10.1038/s41598-017-18062-x
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Scientific Reports

CD8(+) T-cell expansions are the primary manifestation of T-cell large granular lymphocytic leukemia (T-LGLL), which is frequently accompanied by neutropenia and rheumatoid arthritis, and also occur as a secondary phenomenon in leukemia patients trea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::f9e24de48af6f6c041a8bf81d896b8af
https://research-information.bris.ac.uk/en/publications/0597ee29-12c8-44b9-b250-632caa219d9a

Islet-reactive CD8

Autor: Slobodan, Culina, Ana Ines, Lalanne, Georgia, Afonso, Karen, Cerosaletti, Sheena, Pinto, Guido, Sebastiani, Klaudia, Kuranda, Laura, Nigi, Anne, Eugster, Thomas, Østerbye, Alicia, Maugein, James E, McLaren, Kristin, Ladell, Etienne, Larger, Jean-Paul, Beressi, Anna, Lissina, Victor, Appay, Howard W, Davidson, Søren, Buus, David A, Price, Matthias, Kuhn, Ezio, Bonifacio, Manuela, Battaglia, Sophie, Caillat-Zucman, Francesco, Dotta, Raphael, Scharfmann, Bruno, Kyewski, Roberto, Mallone, Anna, Jones

Publikováno v: Science immunology. 3(20)

The human leukocyte antigen (HLA)-A2-restricted zinc transporter (ZnT)8186–194 and other islet epitopes elicit interferon-γ secretion by CD8+ T cells preferentially in type 1 diabetes (T1D) patients compared with controls. Here, we show that clona

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5216bc6ad4f32fe649a7678f097c1828
https://pubmed.ncbi.nlm.nih.gov/29429978

Anti-CD8 antibodies can inhibit or enhance peptide-MHC class I (pMHCI) multimer binding: this is paralleled by their effects on CTL activation and occurs in the absence of an interaction between pMHCI and CD8 on the cell surface

Autor: Linda Wooldridge, P. Rod Dunbar, Vincenzo Cerundolo, David Price, Anna Lissina, Andrew K. Sewell, Emma Jones, Fareed Mirza, Sarah L. Hutchinson, Man-Lik Choi Edward

Publikováno v: Scopus-Elsevier
ResearcherID

Cytotoxic T lymphocytes recognize short peptides presented in association with MHC class I (MHCI) molecules on the surface of target cells. The Ag specificity of T lymphocytes is conferred by the TCR, but invariable regions of the peptide-MHCI (pMHCI

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1790155dee5b6f9ebb3aa23bfc34886
https://ora.ox.ac.uk/objects/uuid:b7d55420-e14b-4a04-b466-8182875bf4e0