Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Anna, Hockaday"'
Autor:
Roger Owen, Mark Cook, David Meads, David A Cairns, Christopher Parrish, Gordon Cook, Kwee Yong, Guy Pratt, Martin Kaiser, Karthik Ramasamy, Graham Jackson, Catherine Olivier, Amy Beth Coulson, Kara-Louise Royle, Anna Hockaday, Ruth de Tute, Bryony Dawkins, Mark Drayson, Jonathan Sive, Holger W Auner, Sergio Quezada, Lorna Barnard, Rhiannon Lambkin, Andrea Paterson, Mike Chapman, Rakesh Popat, Ceri Bygrave, Andrew Chantry, Samir Asher
Publikováno v:
BMJ Open, Vol 12, Iss 11 (2022)
Introduction Multiple myeloma is a plasma cell malignancy that accounts for 1%–2% of newly diagnosed cancers.At diagnosis, approximately 20% of patients can be identified, using cytogenetics, to have inferior survival (high-risk). Additionally, sta
Externí odkaz:
https://doaj.org/article/bf5f5424894a43a2927ade7759c778ff
Autor:
Nina Wilson, Katie Biggs, Sarah Bowden, Julia Brown, Munyaradzi Dimairo, Laura Flight, Jamie Hall, Anna Hockaday, Thomas Jaki, Rachel Lowe, Caroline Murphy, Philip Pallmann, Mark A. Pilling, Claire Snowdon, Matthew R. Sydes, Sofía S. Villar, Christopher J. Weir, Jessica Welburn, Christina Yap, Rebecca Maier, Helen Hancock, James M. S. Wason
Publikováno v:
BMC Medicine, Vol 19, Iss 1, Pp 1-17 (2021)
Abstract Background Adaptive designs offer great promise in improving the efficiency and patient-benefit of clinical trials. An important barrier to further increased use is a lack of understanding about which additional resources are required to con
Externí odkaz:
https://doaj.org/article/54a6d8a22728449aaca970ea965fdb82
Autor:
Roger Owen, John Jones, David Meads, David A Cairns, Christopher Parrish, Gordon Cook, Neil Rabin, Matthew Jenner, Martin Kaiser, Kevin Boyd, Graham Jackson, Catherine Olivier, Amy Beth Coulson, Kara-Louise Royle, Charlotte Pawlyn, Anna Hockaday, Jennifer Bird, Stella Bowcock, Ruth de Tute, Hayley Gardner, Bryony Dawkins, Rowena Henderson, Phillip Best, Bhuvan Kishore, Mark Drayson
Publikováno v:
BMJ Open, Vol 12, Iss 6 (2022)
Externí odkaz:
https://doaj.org/article/3d2818c0a21d4f5daf3843685e054b9c
Autor:
Dena R. Howard, Anna Hockaday, Julia M. Brown, Walter M. Gregory, Susan Todd, Tahla Munir, Jamie B. Oughton, Claire Dimbleby, Peter Hillmen
Publikováno v:
Trials, Vol 22, Iss 1, Pp 1-13 (2021)
Abstract Background The FLAIR trial in chronic lymphocytic leukaemia has a randomised, controlled, open-label, confirmatory, platform design. FLAIR was successfully amended to include an emerging promising experimental therapy to expedite its assessm
Externí odkaz:
https://doaj.org/article/f5a4a538c4cd4e3c8cd38fb1ff778296
Autor:
Graham H Jackson, Charlotte Pawlyn, David A Cairns, Ruth M de Tute, Anna Hockaday, Corinne Collett, John R Jones, Bhuvan Kishore, Mamta Garg, Cathy D Williams, Kamaraj Karunanithi, Jindriska Lindsay, Alberto Rocci, John A Snowden, Matthew W Jenner, Gordon Cook, Nigel H Russell, Mark T Drayson, Walter M Gregory, Martin F Kaiser, Roger G Owen, Faith E Davies, Gareth J Morgan, UK NCRI Haemato-oncology Clinical Studies Group
Publikováno v:
PLoS Medicine, Vol 18, Iss 1, p e1003454 (2021)
BackgroundCarfilzomib is a second-generation irreversible proteasome inhibitor that is efficacious in the treatment of myeloma and carries less risk of peripheral neuropathy than first-generation proteasome inhibitors, making it more amenable to comb
Externí odkaz:
https://doaj.org/article/7fe445c9d7494b4397c8fa9d9a9d2182
Autor:
Matthew W, Jenner, Charlotte, Pawlyn, Faith E, Davies, Tom, Menzies, Anna, Hockaday, Catherine, Olivier, John R, Jones, Kamuraj, Karunanithi, Jindriska, Lindsay, Bhuvan, Kishore, Gordon, Cook, Mark T, Drayson, Martin F, Kaiser, Roger G, Owen, Walter, Gregory, David A, Cairns, Gareth J, Morgan, Graham H, Jackson
Publikováno v:
British Journal of Haematology. 201:267-279
Lenalidomide is an effective maintenance agent for patients with myeloma, prolonging first remission and, in transplant eligible patients, improving overall survival (OS) compared to observation. The 'Myeloma XI' trial, for newly diagnosed patients,
Autor:
Alina Striha, A. John Ashcroft, Anna Hockaday, David A. Cairns, Karen Boardman, Gwen Jacques, Cathy Williams, John A. Snowden, Mamta Garg, Jamie Cavenagh, Kwee Yong, Mark T. Drayson, Roger Owen, Mark Cook, Gordon Cook
Publikováno v:
Trials, Vol 19, Iss 1, Pp 1-14 (2018)
Abstract Background Multiple myeloma (MM) is a plasma cell tumour with an approximate annual incidence of 4500 in the UK. Therapeutic options for patients with MM have changed in the last decade with the arrival of proteasome inhibitors and immunomod
Externí odkaz:
https://doaj.org/article/a804debd98c54c009c1516a296fbdf16
Autor:
Jamie B. Oughton, Laura Collett, Dena R. Howard, Anna Hockaday, Talha Munir, Kathryn McMahon, Lucy McParland, Claire Dimbleby, David Phillips, Andy C. Rawstron, Peter Hillmen
Publikováno v:
Trials, Vol 18, Iss 1, Pp 1-12 (2017)
Abstract Background Chronic lymphocytic leukaemia (CLL) is the most common adult leukaemia. Achieving minimal residual disease (MRD) negativity in CLL is an independent predictor of survival even with a variety of different treatment approaches and r
Externí odkaz:
https://doaj.org/article/85a3ae6118144f27ac5415aae69c87c7
Autor:
Talha Munir, Alexandra Pitchford, Adrian Bloor, Andrew Pettitt, Piers E.M. Patten, Francesco Forconi, Anna Schuh, Christopher P Fox, Simona Gatto, Ben Kennedy, John Gribben, Nicholas Pemberton, Oonagh Sheehy, Gavin Preston, Dena Howard, Anna Hockaday, David Cairns, Sharon Jackson, Natasha Greatorex, Nichola McWhirter, Jane Shingles, Kate Cwynarski, Shankara Paneesha, David Allsup, Andrew Rawstron, Peter Hillmen
Publikováno v:
Blood. 140:231-233
Autor:
Valter Gattei, Giovanni Del Poeta, Francesco Di Raimondo, Francesco Zaja, Annalisa Chiarenza, Davide Rossi, Peter Hillmen, Anna Schuh, Anna Hockaday, Chris Pepper, Pietro Bulian, Jacopo Olivieri, Giovanni D'Arena, Gabriele Pozzato, Gilberto Fronza, Fortunato Morabito, Massimo Gentile, Annalisa Biagi, Enrico Santinelli, Jared A. Cohen, Jerry Polesel, Alessandra Braida, Michele Berton, Paola Nanni, Paola Varaschin, Ilaria Cattarossi, Eva Zaina, Massimo Degan, Elena Vendramini, Federico Pozzo, Erika Tissino, Antonella Zucchetto, Tiziana D'Agaro, Tamara Bittolo, Filippo Vit, Francesca Maria Rossi, Riccardo Bomben
Supplemental Material and Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5a4547e25c77872ace73d776ac6d523
https://doi.org/10.1158/1078-0432.22481244
https://doi.org/10.1158/1078-0432.22481244