Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Anna, Heath"'
Autor:
Mohamed Ben-Eltriki, Aisha Rafiq, Arun Paul, Devashree Prabhu, Michael O. S. Afolabi, Robert Baslhaw, Christine J Neilson, Michelle Driedger, Salaheddin M Mahmud, Thierry Lacaze-Masmonteil, Susan Marlin, Martin Offringa, Nancy Butcher, Anna Heath, Lauren E Kelly
Publikováno v:
BMC Medical Research Methodology, Vol 24, Iss 1, Pp 1-14 (2024)
Abstract Background Adaptive designs (ADs) are intended to make clinical trials more flexible, offering efficiency and potentially cost-saving benefits. Despite a large number of statistical methods in the literature on different adaptations to trial
Externí odkaz:
https://doaj.org/article/41cdff2d92bf4e43a97063f2d77bed85
Autor:
Ziming Chen, MSc, Michael O. Harhay, PhD, Eddy Fan, MD, PhD, Anders Granholm, MD, Daniel F. McAuley, MD, Martin Urner, MD, Christopher J. Yarnell, MD, Ewan C. Goligher, MD, PhD, Anna Heath, PhD
Publikováno v:
Critical Care Explorations, Vol 6, Iss 10, p e1152 (2024)
BACKGROUND:. Patients with acute hypoxemic respiratory failure are at high risk of death and prolonged time on the ventilator. Interventions often aim to reduce both mortality and time on the ventilator. Many methods have been proposed for analyzing
Externí odkaz:
https://doaj.org/article/28444fc2973e46d1818dab9cd8cf50bc
Publikováno v:
BMC Medical Research Methodology, Vol 24, Iss 1, Pp 1-15 (2024)
Abstract Background When studying the association between treatment and a clinical outcome, a parametric multivariable model of the conditional outcome expectation is often used to adjust for covariates. The treatment coefficient of the outcome model
Externí odkaz:
https://doaj.org/article/3e756037f1f949ecb6dafef617cd60f4
Autor:
Christopher J. Yarnell, MD, Kali Barrett, MD, MSc, Anna Heath, PhD, Margaret Herridge, MD, MSc, Robert A. Fowler, MD, MSc, Lillian Sung, MD, PhD, David M. Naimark, MSc, MD, George Tomlinson, PhD
Publikováno v:
Critical Care Explorations, Vol 6, Iss 6, p e1098 (2024)
OBJECTIVES:. To estimate the expected value of undertaking a future randomized controlled trial of thresholds used to initiate invasive ventilation compared with usual care in hypoxemic respiratory failure. PERSPECTIVE:. Publicly funded healthcare pa
Externí odkaz:
https://doaj.org/article/2601503c0569456884dc1fd06ec0d6b4
Autor:
Jingxian Lan, Amy C. Plint, Stuart R. Dalziel, Terry P. Klassen, Martin Offringa, Anna Heath, on behalf of the Pediatric Emergency Research Canada (PERC) KIDSCAN/PREDICT BIPED Study Group
Publikováno v:
Trials, Vol 23, Iss 1, Pp 1-11 (2022)
Abstract Background Bayesian methods are increasing in popularity in clinical research. The design of Bayesian clinical trials requires a prior distribution, which can be elicited from experts. In diseases with international differences in management
Externí odkaz:
https://doaj.org/article/ab706075e4884a5fb3cbdde102416ebd
Autor:
Abhijit Nadkarni, Allison Tu, Ankur Garg, Devika Gupta, Sonal Gupta, Urvita Bhatia, Niharika Tiwari, Anna Heath, Karen Wen, Godwin Fernandes, Richard Velleman
Publikováno v:
Cambridge Prisms: Global Mental Health, Vol 9, Pp 1-25 (2022)
Abstract Background Alcohol use is typically established during adolescence and initiation of use at a young age poses risks for short- and long-term health and social outcomes. However, there is limited understanding of the onset, progression and im
Externí odkaz:
https://doaj.org/article/4109a92e4f214812b6cbe8eaa027223c
Autor:
Alex Aregbesola, Allison Gates, Amanda Coyle, Shannon Sim, Ben Vandermeer, Megan Skakum, Despina Contopoulos-Ioannidis, Anna Heath, Lisa Hartling, Terry P. Klassen
Publikováno v:
Systematic Reviews, Vol 10, Iss 1, Pp 1-4 (2021)
Abstract Background There is an unresolved debate about the reliability of the interpretation of P value. Some investigators have suggested that an alternative Bayesian method is preferred in conducting health research. As randomized-controlled trial
Externí odkaz:
https://doaj.org/article/235f65dd2d2f41a3b1ced49df878d256
Autor:
Samina Ali, Gareth Hopkin, Naveen Poonai, Lawrence Richer, Maryna Yaskina, Anna Heath, Terry Paul Klassen, Chris McCabe, on behalf of the KidsCAN PERC Innovative Pediatric Clinical Trials No OUCH Study Group, the KidsCAN PERC Innovative Pediatric Clinical Trials Methods Core
Publikováno v:
Trials, Vol 22, Iss 1, Pp 1-9 (2021)
Abstract Background Patients and their families often have preferences for medical care that relate to wider considerations beyond the clinical effectiveness of the proposed interventions. Traditionally, these preferences have not been adequately con
Externí odkaz:
https://doaj.org/article/1fbf35c71f7c415fa684f4cd1975fc22
Autor:
Anna Heath, Juan David Rios, Eleanor Pullenayegum, Petros Pechlivanoglou, Martin Offringa, Maryna Yaskina, Rick Watts, Shana Rimmer, Terry P. Klassen, Kamary Coriolano, Naveen Poonai, on behalf of the PERC-KIDSCAN Ketodex Study Group
Publikováno v:
Trials, Vol 22, Iss 1, Pp 1-8 (2021)
Abstract Background Procedural sedation and analgesia (PSA) is frequently required to perform closed reductions for fractures and dislocations in children. Intravenous (IV) ketamine is the most commonly used sedative agent for closed reductions. Howe
Externí odkaz:
https://doaj.org/article/778e53a348fe42a086210f95509ecb0a
Autor:
Anna Heath, Maryna Yaskina, Gareth Hopkin, Terry P. Klassen, Christopher McCabe, Martin Offringa, Petros Pechlivanoglou, Juan David Rios, Naveen Poonai, Samina Ali, on behalf of the KidsCAN PERC Innovative Pediatric Clinical Trials No OUCH Study Group
Publikováno v:
Trials, Vol 21, Iss 1, Pp 1-7 (2020)
Abstract Background Pediatric musculoskeletal injuries cause moderate to severe pain, which should ideally be addressed upon arrival to the emergency department (ED). Despite extensive research in ED-based pediatric pain treatment, recent studies con
Externí odkaz:
https://doaj.org/article/02ee028d568941c180af3c4b9deb9478