Zobrazeno 1 - 10
of 146
pro vyhledávání: '"Anna, Dubrovska"'
The extracellular matrix component perlecan/HSPG2 regulates radioresistance in prostate cancer cells
Autor:
Ivana Samaržija, Vasyl Lukiyanchuk, Marija Lončarić, Anja Rac-Justament, Nikolina Stojanović, Ielizaveta Gorodetska, Uğur Kahya, Jonathan D. Humphries, Mahak Fatima, Martin J. Humphries, Ana Fröbe, Anna Dubrovska, Andreja Ambriović-Ristov
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Radiotherapy of prostate cancer (PC) can lead to the acquisition of radioresistance through molecular mechanisms that involve, in part, cell adhesion-mediated signaling. To define these mechanisms, we employed a DU145 PC model to conduct a comparativ
Externí odkaz:
https://doaj.org/article/1313c7d198bb45ab93487b56f75e5c06
Autor:
Sherif Mehralivand, Christian Thomas, Martin Puhr, Frank Claessens, Arjanneke F. van de Merbel, Anna Dubrovska, Guido Jenster, Christof Bernemann, Ulrich Sommer, Holger H. H. Erb
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-8 (2024)
Abstract The androgen receptor (AR) is a crucial player in various aspects of male reproduction and has been associated with the development and progression of prostate cancer (PCa). Therefore, the protein is the linchpin of current PCa therapies. De
Externí odkaz:
https://doaj.org/article/2100acb6c028487ea1592470d98b2707
Autor:
Pu Xia, Anna Dubrovska
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
The SLC3A2 gene encodes for a cell-surface transmembrane protein CD98hc (4F2). CD98hc serves as a chaperone for LAT1 (SLC7A5), LAT2 (SLC7A8), y+LAT1 (SLC7A7), y+LAT2 (SLC7A6), xCT (SLC7A11) and Asc1 (SLC7A10) providing their recruitment to the plasma
Externí odkaz:
https://doaj.org/article/843b45ff6bcd4388894acbffe12315f2
Autor:
Felix Meyer, Anna Maria Engel, Ann Kristin Krause, Tim Wagner, Lena Poole, Anna Dubrovska, Claudia Peitzsch, Kai Rothkamm, Cordula Petersen, Kerstin Borgmann
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Cancer stem cells (CSCs) are a major cause of tumor therapy failure. This is mainly attributed to increased DNA repair capacity and immune escape. Recent studies have shown that functional DNA repair via homologous recombination (HR) prevents radiati
Externí odkaz:
https://doaj.org/article/fdb2d8df0fc941a283280939b46c8565
Autor:
Dinah Linke, Lukas Donix, Claudia Peitzsch, Holger H. H. Erb, Anna Dubrovska, Manuel Pfeifer, Christian Thomas, Susanne Fuessel, Kati Erdmann
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 1, p 666 (2022)
Docetaxel (DTX) is a mainstay in the treatment of metastatic prostate cancer. Failure of DTX therapy is often associated with multidrug resistance caused by overexpression of efflux membrane transporters of the ABC family such as the glycoprotein ABC
Externí odkaz:
https://doaj.org/article/e6f8e7868a164829a0c4b73361f74359
Autor:
Daria Klusa, Fabian Lohaus, Andre Franken, Marian Baumbach, Monica Cojoc, Paul Dowling, Annett Linge, Anne Offermann, Steffen Löck, Dejan Hušman, Mahdi Rivandi, Bernhard Polzer, Vera Freytag, Tobias Lange, Hans Neubauer, Michael Kücken, Sven Perner, Tobias Hölscher, Anna Dubrovska, Mechthild Krause, Ina Kurth, Michael Baumann, Claudia Peitzsch
Publikováno v:
International Journal of Cancer. 152:2639-2654
Autor:
Anna Mukha, Anna Dubrovska
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Most human tumors possess a high heterogeneity resulting from both clonal evolution and cell differentiation program. The process of cell differentiation is initiated from a population of cancer stem cells (CSCs), which are enriched in tumor‐regene
Externí odkaz:
https://doaj.org/article/4a9c23a9a314461193d2cbc68a73759c
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Ovarian cancer (OC) is one of the most lethal gynecologic malignancies. Due to the lack of specific symptoms and screening methods, this disease is usually diagnosed only at an advanced and metastatic stage. The gold-standard treatment for OC patient
Externí odkaz:
https://doaj.org/article/f6d520293e82493ba66563fd3c927526
Autor:
Claudia Arndt, Liliana R. Loureiro, Anja Feldmann, Justyna Jureczek, Ralf Bergmann, Domokos Máthé, Nikolett Hegedüs, Nicole Berndt, Stefanie Koristka, Nicola Mitwasi, Frederick Fasslrinner, Chris Lamprecht, Alexandra Kegler, Anja Hoffmann, Tabea Bartsch, Ayşe Sedef Köseer, Gary Egan, Marc Schmitz, Vaclav Hořejší, Mechthild Krause, Anna Dubrovska, Michael Bachmann
Publikováno v:
OncoImmunology, Vol 9, Iss 1 (2020)
Induction or selection of radioresistant cancer (stem) cells following standard radiotherapy is presumably one of the major causes for recurrence of metastatic disease. One possibility to prevent tumor relapse is the application of targeted immunothe
Externí odkaz:
https://doaj.org/article/e9bde3c3ab474cab96ef8a34e0e398cf
Autor:
Alexander Schulz, Ielizaveta Gorodetska, Rayk Behrendt, Susanne Fuessel, Kati Erdmann, Sarah Foerster, Kaustubh Datta, Thomas Mayr, Anna Dubrovska, Michael H. Muders
Publikováno v:
Frontiers in Oncology, Vol 9 (2020)
Neuropilin-2 (NRP2) is a prognostic indicator for reduced survival in bladder cancer (BCa) patients. Together with its major ligand, vascular endothelial growth factor (VEGF)-C, NRP2 expression is a predictive factor for treatment outcome in response
Externí odkaz:
https://doaj.org/article/a885c977c66443608873400f9081394f