Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Anna, Di Fiore."'
Autor:
Anna Di Fiore, Viviana De Luca, Emma Langella, Alessio Nocentini, Martina Buonanno, Simona Maria Monti, Claudiu T. Supuran, Clemente Capasso, Giuseppina De Simone
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 4185-4194 (2022)
Melioidosis is a severe disease caused by the highly pathogenic gram-negative bacterium Burkholderia pseudomallei. Several studies have highlighted the broad resistance of this pathogen to many antibiotics and pointed out the pivotal importance of im
Externí odkaz:
https://doaj.org/article/e1e1a715c8fe4cd6b9cd71bf1b21ca33
Autor:
Linda J. Urbański, Andrea Angeli, Vesa P. Hytönen, Anna Di Fiore, Giuseppina De Simone, Seppo Parkkila, Claudiu T. Supuran
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 330-335 (2021)
Sulphonamides and their isosteres are classical inhibitors of the carbonic anhydrase (CAs, EC 4.2.1.1) metalloenzymes. The protozoan pathogen Trichomonas vaginalis encodes two such enzymes belonging to the β-class, TvaCA1 and TvaCA2. Here we report
Externí odkaz:
https://doaj.org/article/6382fcd128d643108745f96bff22092a
Autor:
Linda J. Urbański, Anna Di Fiore, Latifeh Azizi, Vesa P. Hytönen, Marianne Kuuslahti, Martina Buonanno, Simona M. Monti, Andrea Angeli, Reza Zolfaghari Emameh, Claudiu T. Supuran, Giuseppina De Simone, Seppo Parkkila
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1292-1299 (2020)
We report the biochemical and structural characterisation of a beta-carbonic anhydrase (β-CA) from Trichomonas vaginalis, a unicellular parasite responsible for one of the world’s leading sexually transmitted infections, trichomoniasis. CAs are ub
Externí odkaz:
https://doaj.org/article/bb522e938cd9481cb5e365a4cda810fe
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1450-1461 (2020)
Human carbonic anhydrases (CAs) have become a well-recognized target for the design of inhibitors and activators with biomedical applications. Accordingly, an enormous amount of literature is available on their biochemical, functional and structural
Externí odkaz:
https://doaj.org/article/9c30fdbf7a404adfba0a7fc07ac323ee
Autor:
Emma Langella, Anna Di Fiore, Vincenzo Alterio, Simona Maria Monti, Giuseppina De Simone, Katia D’Ambrosio
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 19, p 12045 (2022)
Carbonic anhydrases (CAs) are ubiquitous enzymes that catalyze the reversible carbon dioxide hydration reaction. Among the eight different CA classes existing in nature, the α-class is the largest one being present in animals, bacteria, protozoa, fu
Externí odkaz:
https://doaj.org/article/58af4ea79dbb4331be0929e3bc2f02ca
Autor:
Emma Langella, Vincenzo Alterio, Katia D’Ambrosio, Roberta Cadoni, Jean-Yves Winum, Claudiu T. Supuran, Simona Maria Monti, Giuseppina De Simone, Anna Di Fiore
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 1498-1505 (2019)
Recent studies identified the benzoxaborole moiety as a new zinc-binding group able to interact with carbonic anhydrase (CA) active site. Here, we report a structural analysis of benzoxaboroles containing urea/thiourea groups, showing that these mole
Externí odkaz:
https://doaj.org/article/83251cf196c344de85ae41f9443a013d
Autor:
Giuseppina De Simone, Anna Di Fiore, Emanuela Truppo, Emma Langella, Daniela Vullo, Claudiu T. Supuran, Simona Maria Monti
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 1506-1510 (2019)
Carbonic anhydrases (CAs) are ubiquitous metallo-enzymes that catalyse the reversible hydration of carbon dioxide to bicarbonate and proton. In humans there are 15 isoforms among which only 12 are catalytically active. Since active human (h) CAs show
Externí odkaz:
https://doaj.org/article/9f170bbeb47743aa83686eb06fe82839
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 4, p 2160 (2022)
The Chromatin Assembly Factor 1 is a heterotrimeric complex responsible for the nucleosome assembly during DNA replication and DNA repair. In humans, the largest subunit P150 is the major actor of this process. It has been recently considered as a tu
Externí odkaz:
https://doaj.org/article/65ed5b919bd844afac27d3cb79b6e133
Autor:
Daria M. Monti, Giuseppina De Simone, Emma Langella, Claudiu T. Supuran, Anna Di Fiore, Simona M. Monti
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 32, Iss 1, Pp 5-12 (2017)
Carbonic anhydrases (CAs) III and VII are two cytosolic isoforms of the α-CA family which catalyze the physiological reaction of carbon dioxide hydration to bicarbonate and proton. Despite these two enzymes share a 49% sequence identity and present
Externí odkaz:
https://doaj.org/article/b0296123495643ca904d6b9b66899f58
Autor:
Barry V.L. Potter, Michael J. Reed, Atul Purohit, Giuseppina De Simone, Claudiu T. Supuran, Anna Di Fiore, Surinder K. Chander, Paul A. Foster, Melanie Trusselle, Christopher M. Sharland, Delphine S. Fischer, L.W. Lawrence Woo
An improved steroid sulfatase inhibitor was prepared by replacing the N-propyl group of the second-generation steroid-like inhibitor (2) with a N-3,3,3-trifluoropropyl group to give (10). This compound is 5-fold more potent in vitro, completely inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::307513e2cd22b51445121ac51dc9b2b6
https://doi.org/10.1158/1535-7163.c.6531333.v1
https://doi.org/10.1158/1535-7163.c.6531333.v1