Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Anna, Bottoncetti"'
Autor:
E. Vanzi, Nicoletta Cini, Lido Calorini, Francesca Bianchini, Antonio Guarna, Gloria Menchi, Alberto Pupi, Andrea Trabocchi, S. Raspanti, Anna Bottoncetti
Publikováno v:
Journal of Medicinal Chemistry. 55:5024-5033
In this paper, using a hybrid small-animal Micro SPECT/CT imaging system, we report that a new (125)I-Cilengitide-like RGD-cyclopentapeptide, containing d-morpholine-3-carboxylic acid, interacts in vivo with α(v)β(3) integrin expressed by melanoma
Autor:
Gloria Menchi, Anna Bottoncetti, Elisa Danieli, Alberto Pupi, Antonio Guarna, S. Raspanti, Donatella Potenza, and Andrea Trabocchi, Nicoletta Cini
Publikováno v:
Amino Acids. 38:329-337
3-Aza-6,8-dioxabicyclo[3.2.1]octane-based amino acids as reverse turn inducers have been introduced into cyclic peptidomimetics containing the RGD or DGR retro-sequence, in order to achieve a stereochemical scanning of the binding capability of the r
Autor:
Anna Bottoncetti, Antonio Guarna, Alberto Pupi, Andrea Trabocchi, Gloria Menchi, Nicoletta Cini, S. Raspanti
Publikováno v:
Bioorganic & Medicinal Chemistry. 17:1542-1549
Two c[RGDfX] cyclopeptides, having either L- or D-morpholine-3-COOH (Mor) as the X amino acid were developed as ligands for alpha(v)beta(3)/alpha(v)beta(5) integrins. Biological assays showed only d-Mor-containing cyclopentapeptide capable to bind al
Autor:
Ciro Franzese, S. Cassani, Francesca Castiglione, Icro Meattini, Daniela Greto, Pierluigi Bonomo, Anna Bottoncetti, Lorenzo Livi, Monica Mangoni, Alberto Pupi, E. Vanzi, T. Masoni, Mariangela Sottili, Chiara Gerini, Stefania Pallotta, Alessandro Passeri, Giampaolo Biti
Publikováno v:
Lung cancer (Amsterdam, Netherlands). 90(3)
Purpose/objective(s) Due to its anti-inflammatory, antifibrotic and antineoplastic properties, the PPAR-γ agonist rosiglitazone is of interest in the prevention and therapy of radiation-induced pulmonary injury. We evaluated the radioprotective effe
Autor:
Franca M. Cordero, Anna Bottoncetti, Federica Pisaneschi, Alberto Brandi, Nicoletta Cini, Maria Salvati
Publikováno v:
Synlett. 2006:2067-2070
The solid-phase synthesis of cyclic pseudopeptides con- taining the Arg-Gly-Asp recognition sequence and the dipeptide isostere 2-amino-3-oxotetrahydro-1H-pyrrolizine-7a(5H)-carboxy- lic acid (GPTM) was accomplished. N-Fmoc-Asp-OAll was an- chored to
Autor:
Alessandro Passeri, Alberto Pupi, Antonio Guarna, Elena Andreucci, Anna Bottoncetti, Francesca Bianchini, Andrea Trabocchi, Pierangelo Fabbrizzi, Gloria Menchi, Lido Calorini, S. Raspanti
Publikováno v:
Bioorganicmedicinal chemistry. 23(5)
Taking advantage of click chemistry, we synthesized triazole-containing RGD peptidomimetics capable of binding to α v β 3 integrin with diverse potency, and selected 125 I-labeled compounds proved to interact in vitro and in vivo with α v β 3 int
Autor:
Nicoletta Cini, S. Raspanti, Giovanna Berti, Alessandro Politi, Alberto Pupi, Anna Bottoncetti, Antonio Guarna, Gloria Menchi
Publikováno v:
Bioorganic & Medicinal Chemistry. 9:3197-3206
The synthesis and a preliminary biological characterization of a new class of N -benzyl-aminoalcohols which have serotonin (5-HT 2 ) and dopamine (D 2 ) receptor affinity is described. In vitro competition binding studies were conducted with the new
Autor:
Francesca, Bianchini, Nicoletta, Cini, Andrea, Trabocchi, Anna, Bottoncetti, Silvia, Raspanti, Eleonora, Vanzi, Gloria, Menchi, Antonio, Guarna, Alberto, Pupi, Lido, Calorini
Publikováno v:
Journal of medicinal chemistry. 55(11)
In this paper, using a hybrid small-animal Micro SPECT/CT imaging system, we report that a new (125)I-Cilengitide-like RGD-cyclopentapeptide, containing d-morpholine-3-carboxylic acid, interacts in vivo with α(v)β(3) integrin expressed by melanoma
Autor:
Nicoletta Cini, S. Raspanti, Lido Calorini, Gloria Menchi, Andrea Trabocchi, Antonio Guarna, Anna Bottoncetti, Alberto Pupi, Francesca Bianchini
Publikováno v:
Journal of medicinal chemistry. 53(19)
A click chemistry approach was applied for the discovery of triazole-based arginine-glycine-aspartate (RGD) mimetics by Cu(I)-catalyzed 1,3-dipolar alkyne-azide coupling reaction, which showed binding affinity properties toward α(v)β(3)/α(v)β(5)
Autor:
Franca, Zanardi, Paola, Burreddu, Gloria, Rassu, Luciana, Auzzas, Lucia, Battistini, Claudio, Curti, Andrea, Sartori, Giuseppe, Nicastro, Gloria, Menchi, Nicoletta, Cini, Anna, Bottoncetti, Anna, Bottonocetti, Silvia, Raspanti, Giovanni, Casiraghi
Publikováno v:
Journal of medicinal chemistry. 51(6)
The embodiment of 4-aminoproline residues (Amp) into the arginine-glycine-aspartate (RGD) sequence led to the discovery of a novel class of high-affinity alpha Vbeta 3/alpha Vbeta 5 integrin binders [IC 50 h (alpha Vbeta 3) 0.03-5.12 nM; IC 50 h (alp