Isolation of a Complex Formed Between Acinetobacter baumannii HemA and HemL, Key Enzymes of Tetrapyrroles Biosynthesis

Autor: Caterina Nardella, Dalila Boi, Martino L. di Salvo, Anna Barile, Jörg Stetefeld, Angela Tramonti, Roberto Contestabile

Publikováno v: Frontiers in Molecular Biosciences, Vol 6 (2019)

Plants, algae and most bacteria synthesize 5-aminolevulinic acid (ALA), the universal precursor of tetrapyrroles such as heme, chlorophyll and coenzyme B12, by a two-step transformation involving the NADPH-dependent glutamyl-tRNA reductase (HemA), wh

Externí odkaz: https://doaj.org/article/f6b62f13cb774065ae47e035283aa94c

Characterization of the Escherichia coli pyridoxal 5′‐phosphate homeostasis protein ( YggS ): Role of lysine residues in PLP binding and protein stability

Autor: Angela Tramonti, Mohini S. Ghatge, Jill T. Babor, Faik N. Musayev, Martino Luigi di Salvo, Anna Barile, Gianni Colotti, Alessandra Giorgi, Steven D. Paredes, Akua K. Donkor, Mohammed H. Al Mughram, Valérie de Crécy‐Lagard, Martin K. Safo, Roberto Contestabile

Publikováno v: Protein Science. 31

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9f1d280071cda43375a425e6eeb9a338
https://doi.org/10.1002/pro.4471

Characterization of Novel Pathogenic Variants Causing Pyridox(am)ine 5′-Phosphate Oxidase-Dependent Epilepsy

Autor: Claudio Graziani, Victoria I. Bunik, Roberto Contestabile, Anna Barile, Martino L. di Salvo, Peter E. Clayton, Philippa B. Mills, Angela Tramonti

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 21
International journal of molecular sciences
22 (2021). doi:10.3390/ijms222112013
info:cnr-pdr/source/autori:Barile, Anna; Mills, Philippa; Di Salvo, Martino L.; Graziani, Claudio; Bunik, Victoria; Clayton, Peter; Contestabile, Roberto; Tramonti, Angela/titolo:Characterization of novel pathogenic variants causing pyridox(am)ine 5'-phosphate oxidase-dependent epilepsy/doi:10.3390%2Fijms222112013/rivista:International journal of molecular sciences (Print)/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume:22
International Journal of Molecular Sciences, Vol 22, Iss 12013, p 12013 (2021)

Several variants of the enzyme pyridox(am)ine 5′-phosphate oxidase (PNPO), responsible for a rare form of vitamin B6-dependent neonatal epileptic encephalopathy known as PNPO deficiency (PNPOD), have been reported. However, only a few of them have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90430761f2ec83dba1adec7ec36fc808

Knowns and unknowns of vitamin B6 metabolism in escherichia coli

Autor: Angela Tramonti, Federico D’Alessio, Roberto Contestabile, Valérie de Crécy-Lagard, Anna Barile, Martino L. di Salvo, Caterina Nardella

Publikováno v: Ecosal Plus 9 (2021). doi:10.1128/ecosalplus.ESP-0004-2021
info:cnr-pdr/source/autori:Tramonti, Angela; Nardella, Caterina; di Salvo, Martino L.; Barile, Anna; D'Alessio, Federico; de Crécy-Lagard, Valérie; Contestabile, Roberto/titolo:Knowns and Unknowns of Vitamin B6 Metabolism in Escherichia coli/doi:10.1128%2Fecosalplus.ESP-0004-2021/rivista:Ecosal Plus/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume:9

Vitamin B6 is an ensemble of six interconvertible vitamers: pyridoxine (PN), pyridoxamine (PM), pyridoxal (PL), and their 5'-phosphate derivatives, PNP, PMP, and PLP. Pyridoxal 5'-phosphate is a coenzyme in a variety of enzyme reactions concerning tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01cbe6fae275d6b2e2a0fd23262b801b
http://hdl.handle.net/11573/1540157

The expression of four pyridoxal kinase (PDXK) human variants in Drosophila impacts on genome integrity

Autor: Anna Barile, Fabrizio Barbetti, Martino L. di Salvo, Isabella Saggio, Arianna Massimi, Chiara Merigliano, Noemi Amoroso, Roberto Contestabile, Fiammetta Vernì, Lorenzo Stufera Mecarelli, Angela Tramonti, Torben Hansen, Elisa Mascolo

Publikováno v: Scientific reports (Nature Publishing Group) 9 (2019). doi:10.1038/s41598-019-50673-4
info:cnr-pdr/source/autori:Mascolo, Elisa; Barile, Anna; Mecarelli, Lorenzo Stufera; Amoroso, Noemi; Merigliano, Chiara; Massimi, Arianna; Saggio, Isabella; Hansen, Torben; Tramonti, Angela; Di Salvo, Martino Luigi; Barbetti, Fabrizio; Contestabile, Roberto; Verni, Fiammetta/titolo:The expression of four pyridoxal kinase (PDXK) human variants in Drosophila impacts on genome integrity/doi:10.1038%2Fs41598-019-50673-4/rivista:Scientific reports (Nature Publishing Group)/anno:2019/pagina_da:/pagina_a:/intervallo_pagine:/volume:9
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Mascolo, E, Barile, A, Mecarelli, L S, Amoroso, N, Merigliano, C, Massimi, A, Saggio, I, Hansen, T, Tramonti, A, Di Salvo, M L, Barbetti, F, Contestabile, R & Verni, F 2019, ' The expression of four pyridoxal kinase (PDXK) human variants in Drosophila impacts on genome integrity ', Scientific Reports, vol. 9 . https://doi.org/10.1038/s41598-019-50673-4
Scientific Reports

In eukaryotes, pyridoxal kinase (PDXK) acts in vitamin B6salvage pathway to produce pyridoxal 5′-phosphate (PLP), the active form of the vitamin, which is implicated in numerous crucial metabolic reactions. In Drosophila, mutations in the dPdxk gen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f66d13f40663ee1e60bdedc4aeb4088
https://doi.org/10.1038/s41598-019-50673-4