Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Ann-Marie Ritchie"'
Autor:
Liang Song, Ewan M. McNeil, Ann-Marie Ritchie, Katy R. Astell, Charlie Gourley, David W. Melton
Publikováno v:
BMC Cancer, Vol 17, Iss 1, Pp 1-14 (2017)
Abstract Background The global incidence of melanoma has been increasing faster than any other form of cancer. New therapies offer exciting prospects for improved survival, but the development of resistance is a major problem and there remains a need
Externí odkaz:
https://doaj.org/article/7ad027d6ba824e33a5c51694505d0868
Publikováno v:
Oncotarget
Yang, L, Ritchie, A-M & Melton, D 2017, ' Disruption of DNA repair in cancer cells by ubiquitination of a destabilising dimerization domain of nucleotide excision repair protein ERCC1 ', Oncotarget . https://doi.org/10.18632/oncotarget.19422
Yang, L, Ritchie, A-M & Melton, D 2017, ' Disruption of DNA repair in cancer cells by ubiquitination of a destabilising dimerization domain of nucleotide excision repair protein ERCC1 ', Oncotarget . https://doi.org/10.18632/oncotarget.19422
// Lanlan Yang 1 , Ann-Marie Ritchie 1 and David W. Melton 1 1 Edinburgh Cancer Research Centre, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK Correspondence to: David W. M
Autor:
David W. Melton, Douglas R. Houston, Preeti Bakrania, Martin A. Wear, Barbara Saxty, Ann Marie Ritchie, Steven Shave, Tim Chapman, Katy R. Astell, Puneet Khurana, Claire Wallace, Ewan M. McNeil, Malcolm D. Walkinshaw, Hayley M. Jones
Publikováno v:
McNeil, E M, Astell, K R, Ritchie, A-M, Shave, S, Houston, D R, Bakrania, P, Jones, H M, Khurana, P, Wallace, C, Chapman, T, Wear, M A, Walkinshaw, M D, Saxty, B & Melton, D W 2015, ' Inhibition of the ERCC1-XPF structure-specific endonuclease to overcome cancer chemoresistance ', DNA Repair, vol. 31, pp. 19-28 . https://doi.org/10.1016/j.dnarep.2015.04.002
ERCC1-XPF is a structure-specific endonuclease that is required for the repair of DNA lesions, generated by the widely used platinum-containing cancer chemotherapeutics such as cisplatin, through the Nucleotide Excision Repair and Interstrand Crossli
Figure S1. Western blots showing that the reduction in RAD51 levels after cisplatin treatment in melanoma cells is not seen in other cell types. Blots support the RAD51 quantification shown in Fig. 2 of the main text. Figure S2. Images showing that R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1a9b32f8f267cdb686b9673b76abaad
Publikováno v:
DNA Repair. 12:1000-1006
Nitrofurans are commonly used for the treatment of trypanosomal diseases including Chagas disease. More recently, following the fortuitous discovery that nifurtimox was clinically active against neuroblastoma, nitrofuran compounds are being investiga
Publikováno v:
Pigment Cell & Melanoma Research. 25:188-199
The mitogen-activated protein kinase (MAPK) pathway is important in melanoma. In this pathway, DUSP6 phosphatase negatively controls the activation of extracellular signal-regulated (ERK) kinase. Through comparison of melanoma signalling pathways bet
Publikováno v:
Pigment Cell & Melanoma Research. 24:966-971
Summary Increased expression of DNA repair genes contributes to the extreme resistance shown by melanoma to conventional DNA-damaging chemotherapeutics. One such chemotherapeutic effective against a range of other cancers, but not melanoma, is cispla
Autor:
Charles E. Patek, Rachel L. Berry, Ann-Marie Ritchie, Feijun Luo, Paul S. Devenney, Lorraine Rose, Sarah J. Plowman, Mark J. Arends, Martin L. Hooper, David G. Brownstein, David J. Harrison
Publikováno v:
Experimental Cell Research. 312:16-26
Ras proteins function as molecular switches in signal transduction pathways, and, here, we examined the effects of the K-ras4A and 413 splice variants on cell function by comparing wild-type embryonic stem (ES) cells with K-ras(tm Delta 4A/tm Delta 4
Autor:
Ann-Marie Ritchie, David W. Melton, Jim Selfridge, Denis Jullien, Shirin Khalili, Kathryn Robertson, Fiona E. Pryde, Yasuhisa Adachi
Publikováno v:
Journal of Cell Science. 118:2043-2055
53BP1 protein is re-localized to the sites of DNA damage after ionizing radiation (IR) and is involved in DNA-damage-checkpoint signal transduction. We examined the dynamics of GFP-53BP1 in living cells. The protein starts to accumulate at the sites
Publikováno v:
Pigment cellmelanoma research. 25(2)
The mitogen-activated protein kinase (MAPK) pathway is important in melanoma. In this pathway, DUSP6 phosphatase negatively controls the activation of extracellular signal-regulated (ERK) kinase. Through comparison of melanoma signalling pathways bet