Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Ann-Marie Conway"'
Publikováno v:
Synapse. 61:463-468
Most forms of neuronal plasticity are associated with induction of the transcription factor zif268 (egr1). Down-regulation of cdc20 (p55(cdc))--a regulatory protein for the anaphase-promoting complex, which controls access of specific substrates to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f07f0cf14a34283c41b979ad4167e9e3
https://doi.org/10.1002/syn.20387
https://doi.org/10.1002/syn.20387
Autor:
Joseph, Muenzer, James E, Wraith, Michael, Beck, Roberto, Giugliani, Paul, Harmatz, Christine M, Eng, Ashok, Vellodi, Rick, Martin, Uma, Ramaswami, Muge, Gucsavas-Calikoglu, Suresh, Vijayaraghavan, Susanne, Wendt, Suzanne, Wendt, Ana Cristina, Puga, Antonio, Puga, Brian, Ulbrich, Marwan, Shinawi, Maureen, Cleary, Diane, Piper, Anne Marie, Conway, Ann Marie, Conway, Alan, Kimura
Publikováno v:
Genetics in Medicine. 8:465-473
Purpose: To evaluate the safety and efficacy of recombinant human iduronate-2-sulfatase (idursulfase) in the treatment of mucopolysaccharidosis II. Methods: Ninety-six mucopolysaccharidosis II patients between 5 and 31 years of age were enrolled in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc9ed62ed0dbcc159b373e89c37ba401
https://doi.org/10.1097/01.gim.0000232477.37660.fb
https://doi.org/10.1097/01.gim.0000232477.37660.fb
Publikováno v:
Journal of Neurochemistry. 95:796-810
The later phases of neuronal plasticity are invariably dependent on gene transcription. Induction of the transcription factor Zif268 (Egr-1) in neurones is closely associated with many forms of functional plasticity, yet the neuronal target genes mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fefb1985679c121d9af5e9348842dcda
https://doi.org/10.1111/j.1471-4159.2005.03400.x
https://doi.org/10.1111/j.1471-4159.2005.03400.x
Publikováno v:
Experimental Cell Research. 300:35-42
The phosphorylation of myosin light chain (MLC) is a key regulatory point in the control of cellular morphology. Evidence suggests that RhoA-a member of the Rho GTPase family-regulates MLC phosphorylation via Rho kinase (ROK). Neurones display subtle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4c1b1b486a99f52680f0173df6b6221
https://doi.org/10.1016/j.yexcr.2004.06.022
https://doi.org/10.1016/j.yexcr.2004.06.022
Publikováno v:
Biochemical Society Transactions. 37:1375-1377
The regulation of synaptic glutamate receptor and GABAAR (γ-aminobutyric acid subtype A receptor) levels is a key component of synaptic plasticity. Most forms of neuronal plasticity are associated with the induction of the transcription factor zif26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcdd144ac2707fa63954d4795c357ead
https://doi.org/10.1042/bst0371375
https://doi.org/10.1042/bst0371375
Publikováno v:
Biochemical Journal. 337:171-177
The mechanism used by the platelet-derived growth factor receptor (PDGFR) to activate the mitogen-activated- protein-kinase (p42/p44 MAPK) pathway was investigated in cultured airway smooth muscle (ASM) cells. We have found that pertussis toxin (PTX,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2bb3ca5ccdd494de7e8d7618e305197c
https://doi.org/10.1042/bj3370171
https://doi.org/10.1042/bj3370171
Publikováno v:
American Journal of Physiology-Cell Physiology. 273:C928-C936
Because many agonists utilize diacylglycerol (DAG) to initiate nuclear transcriptional activity via protein kinase C (PKC), we have investigated whether sphingosine might counter DAG. Sphingosine inhibited PKC activity in an isolated airway smooth mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2397ccd28c00e234ed28a1d1db312ccc
https://doi.org/10.1152/ajpcell.1997.273.3.c928
https://doi.org/10.1152/ajpcell.1997.273.3.c928
Publikováno v:
Cellular signalling. 16(12)
A number of candidate Egr-1 neuronal target genes have been identified including the synapsin I gene. Previous studies have shown that over-expression of Egr-1 in cells transfected with an Egr-1 expression vector is sufficient to activate reporter ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9618c9ed7b3fc2345e2b47dd51537d96
https://pubmed.ncbi.nlm.nih.gov/15381251
https://pubmed.ncbi.nlm.nih.gov/15381251
Publikováno v:
Cellular signalling. 12(11-12)
Previous studies have demonstrated that a number of biochemical actions of ceramide are mediated through protein kinase signalling pathways, such as p42/p44 mitogen-activated protein kinase (p42/p44 MAPK) and c-Jun N-terminal directed protein kinase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8337fd61c4780371e5c9ef472a60d40
https://pubmed.ncbi.nlm.nih.gov/11152959
https://pubmed.ncbi.nlm.nih.gov/11152959
Autor:
Ann-Marie Conway, Soma Rakhit, Nigel J. Pyne, Susan Pyne, Peter I. Darroch, Rothwelle J. Tate, Amanda E. McKie
Publikováno v:
Biochemical Society transactions. 27(4)
Sphingosine 1-phosphate (SIP) belongs to a group of platelet-derived lipid mediators that regulate cell differentiation, survival and proliferation. It is released from platelets after their activation with agents such as thrombin [l]. In addition, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c53cc7e7b57bdcb1cc98d415b1fec9d
https://pubmed.ncbi.nlm.nih.gov/10917611
https://pubmed.ncbi.nlm.nih.gov/10917611