Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Ann-Marie Chacko"'
Autor:
Carla Bianca Luena Victorio, Wisna Novera, Arun Ganasarajah, Joanne Ong, Melisyaa Thomas, Jonas Wu, Hilary Si Yin Toh, Alfred Xuyang Sun, Eng Eong Ooi, Ann-Marie Chacko
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-16 (2024)
Abstract Glioblastoma multiforme (GBM) is the most common malignant primary brain cancer affecting the adult population. Median overall survival for GBM patients is poor (15 months), primarily due to high rates of tumour recurrence and the paucity of
Externí odkaz:
https://doaj.org/article/ee0a50612b5542f497fd6d538bc211a5
Autor:
Carla Bianca Luena Victorio, Arun Ganasarajah, Wisna Novera, Joanne Ong, Rasha Msallam, Ann-Marie Chacko
Publikováno v:
Emerging Microbes and Infections, Vol 13, Iss 1 (2024)
Zika is a systemic inflammatory disease caused by infection with Zika virus (ZIKV). ZIKV infection in adults is associated with encephalitis marked by elevated expression of pro-inflammatory cytokines and chemokines, as well as increased brain infilt
Externí odkaz:
https://doaj.org/article/53eaa171a4204e599923009432e5478a
Autor:
Julian L. Goggi, Boominathan Ramasamy, Yun Xuan Tan, Siddesh V. Hartimath, Jun Rong Tang, Peter Cheng, Rasha Msallam, Ann-Marie Chacko, You Yi Hwang, Edward G. Robins
Publikováno v:
Molecular Imaging, Vol 2021 (2021)
Hepatocellular carcinoma (HCC) is a notoriously difficult cancer to treat. The recent development of immune checkpoint inhibitors has revolutionised HCC therapy; however, successful response is only observed in a small percentage of patients. Biomark
Externí odkaz:
https://doaj.org/article/80a593fefbf7406eb9f2970c1f86d7e6
Autor:
Carla Bianca Luena Victorio, Rasha Msallam, Wisna Novera, Joanne Ong, Tham Jing Yang, Arun Ganasarajah, Jenny Low, Satoru Watanabe, Ann-Marie Chacko
Publikováno v:
European Journal of Nuclear Medicine and Molecular Imaging. 50:742-755
Introduction Zika virus (ZIKV) is a neurotropic human pathogen that causes neuroinflammation, whose hallmark is elevated translocator protein (TSPO) expression in the brain. This study investigates ZIKV-associated changes in adult brain TSPO expressi
Autor:
Carla Bianca Luena Victorio, Wisna Novera, Jing Yang Tham, Satoru Watanabe, Subhash G. Vasudevan, Ann-Marie Chacko
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 23, p 9260 (2020)
Current methods to detect and monitor pathogens in biological systems are largely limited by the tradeoffs between spatial context and temporal detail. A new generation of molecular tracking that provides both information simultaneously involves in s
Externí odkaz:
https://doaj.org/article/420de41c915449d1addd6fa6ae7733a6
Autor:
Sai Wang, Marie Jennifer Reolo, Ann-Marie Chacko, Min Jie Alvin Tan, Satoru Watanabe, Milly M. Choy, Carla Bianca Luena Victorio, Menchie Manuel, Subhash G. Vasudevan, Kitti Wing Ki Chan, Colin X Cheng, Joanne Ong
Publikováno v:
ACS Infectious Diseases. 7:3277-3291
Dengue virus (DENV) non-structural protein 5 (NS5) is critical for viral RNA synthesis within endoplasmic reticulum (ER)-derived replication complexes in the cytoplasm; however a proportion of NS5 is known to be localized to the nucleus of infected c
Autor:
Raisa Kiseleva, Colin F Greineder, Carlos H Villa, Elizabeth D Hood, Vladimir V Shuvaev, Jing Sun, Ann-Marie Chacko, Valsamma Abraham, Horace M DeLisser, Vladimir R Muzykantov
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0169537 (2017)
Monoclonal antibodies (mAbs) directed to extracellular epitopes of human and mouse Platelet Endothelial Cell Adhesion Molecule-1 (CD31 or PECAM-1) stimulate binding of other mAbs to distinct adjacent PECAM-1 epitopes. This effect, dubbed Collaborativ
Externí odkaz:
https://doaj.org/article/9155c748285141548f446cfe89f90dc4
Autor:
Julian L. Goggi, You Yi Hwang, Siddesh V. Hartimath, Beverly Jieu, Shivashankar Khanapur, Tsz Ying Yuen, Tan Yun Xuan, Laurent Rénia, Ann-Marie Chacko, Rasha Msallam, Yong Fui Fong, Peter Cheng, Boominathan Ramasamy, Tang Jun Rong, Edward G. Robins, Hui Xian Chin, Charles W. Johannes
Publikováno v:
Molecular Imaging and Biology
Purpose Chemotherapeutic adjuvants, such as oxaliplatin (OXA) and 5-fluorouracil (5-FU), that enhance the immune system, are being assessed as strategies to improve durable response rates when used in combination with immune checkpoint inhibitor (ICI
Autor:
Carla Bianca Luena Victorio, Joanne Ong, Jing Yang Tham, Marie Jennifer Reolo, Wisna Novera, Rasha Msallam, Satoru Watanabe, Shirin Kalimuddin, Jenny G. Low, Subhash G. Vasudevan, Ann-Marie Chacko
Publikováno v:
European journal of nuclear medicine and molecular imaging. 49(13)
Purpose Zika (ZIKV) is a viral inflammatory disease affecting adults, children, and developing fetuses. It is endemic to tropical and sub-tropical countries, resulting in half the global population at risk of infection. Despite this, there are no app
Autor:
Tsz Ying Yuen, Lingfan Jiang, Y. Y. Hwang, H. X. Chin, Beverly Jieu, Yingrou Tan, J. R. Tang, Julian L. Goggi, Charles W. Johannes, Siddesh V. Hartimath, Peter Cheng, Edward G. Robins, Laurent Rénia, Anis Larbi, Ann-Marie Chacko, R. Boominathan
Publikováno v:
Molecular Imaging and Biology
Purpose Immune checkpoint inhibitor (ICI) monotherapy and combination regimens are being actively pursued as strategies to improve durable response rates in cancer patients. However, the biology surrounding combination therapies is not well understoo