Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Ann-Marie Broeske"'
Autor:
Maurizio Ceppi, Marta Canamero, Wei-Yi Cheng, Anton Kraxner, Franziska Braun, Emilia Andersson, Suzana Vega Harring, Sebastian Dziadek, Ann-Marie Broeske, Volker Teichgraeber, Jehad Charo
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/dad4b54948df420886d39ae9ac2547a4
Autor:
Franziska Braun, Sebastian Dziadek, Wei-Yi Cheng, Jehad Charo, Suzana Vega Harring, Volker Teichgraeber, Maurizio Ceppi, Canamero Marta, Anton Kraxner, Emilia Andersson, Ann-Marie Broeske
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundCarcinoma associated fibroblasts (CAFs) play important roles in modulating tumor development and prognosis through biochemical and biomechanical signals, but also through their immuno-modulatory characteristics. Fibroblast activation protei
Autor:
Suzana Vega Harring, Tsao Tsu-Shuen, Sebastian Dziadek, Mike Flores, Maurizio Ceppi, Noah Theiss, Anton Kraxner, Jehad Charo, Emilia Andersson, Wei-Yi Cheng, Ann-Marie Broeske, Tai-Hsien, Gabriele Gabriele Hoelzlwimmer
Publikováno v:
Journal for ImmunoTherapy of Cancer. 9:A94-A94
BackgroundFibroblast activation protein alpha (FAP) is frequently over-expressed in the tumor microenvironment (TME) while exhibiting limited expression in normal tissues. FAP expression was reported to be immunosuppressive in tumor mouse models and
Autor:
Pablo Umana, Ann-Marie Broeske, Franck Morschhauser, Natalie Dimier, Peter N. Morcos, Fritz Offner, Denise Thomas, Carmelo Carlo-Stella, Michael Dickinson, Gilles Salles, Tom Moore, Michael Crump, J. Martinez, Martin Weisser, Cristiano Ferlini, Martin Hutchings, Marina Bacac, Gloria Iacoboni, Anna Sureda
Publikováno v:
Hematological Oncology. 37:92-93
Autor:
Ann-Marie Broeske, Gabriele Hoelzlwimmer, Stefanie Lechner, Esther Abraham, Peter Bruenker, Hadassa Sade, Thomas Friess, Oliver Krieter
Publikováno v:
Molecular Cancer Therapeutics. 14:C125-C125
Introduction RG7386 is a novel bispecific antibody, binding with high affinity to fibroblast activation protein (FAP) and with low affinity to death receptor 5 (DR5). Avidity-driven binding of the bispecific antibody mediates hyper-clustering of DR5
Autor:
Peter Bruenker, Esther Abraham, Stefanie Lechner, Suzana Vega-Harring, Meher Majety, Sabine Bader, Katharina Wartha, Andreas Roller, Hadassah Sade, Thomas Friess, Ann-Marie Broeske, Oliver Krieter
Publikováno v:
Cancer Research. 75:952-952
Background: Activation of the extrinsic apoptotic pathway by TRAIL is dependent on clustering of death receptors (DR) on the surface of cells. However, current TRAIL-based strategies have proven ineffective in clustering death receptors and failed to
Autor:
Christophe Le Tourneau, Philippe A. Cassier, Valeria Runza, Joerg Benz, Flora Rey-Giraud, Keelara Abiraj, Carlos Gomez-Roca, Jean-Pierre Delord, Carola Ries, Michael A. Cannarile, Ute Jucknischke, Jean-Yves Blay, Dominik Ruettinger, Stefan Scheiblich, Friedrich Feuerhake, Antoine Italiano, Antonio Sica, Tobin Jones, Irina Klaman, Sabine Hoves, Ingo H. Gorr, Hyam I. Levitsky, Ann-Marie Broeske, Katharina Wartha, Leon P. Pradel, Antje Walz
Publikováno v:
Cancer Research. 75:PR04-PR04
Myeloid cells represent the most abundant immune cell type within the tumor microenvironment of certain tumor entities, including tumor associated macrophages (TAMs). Macrophage infiltration has been identified as an independent poor prognostic facto
Autor:
Dominik Ruettinger, Friedrich Feuerhake, Ann-Marie Broeske, Kai Habben, Michael A. Cannarile, Florian Heil, Lisa Culton, Carola Ries
Publikováno v:
Cancer Research. 73:4719-4719
Early Phase I clinical development of RG7155, a humanized anti-CSF-1R monoclonal antibody binding to dimerization interface of CSF-1 receptor and inducing apoptosis in CSF-1R expressing macrophages is accompanied by an extensive biomarker program. Ph