Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Ann-Kristin Leuchs"'
Autor:
Florence Butlen-Ducuing, Marion Haberkamp, Georgios Aislaitner, Ewa Bałkowiec-Iskra, Taina Mattila, Marika Doucet, Marta Kollb-Sielecka, Pavel Balabanov, Ann-Kristin Leuchs, André Elferink
Publikováno v:
European Psychiatry, Vol 67 (2024)
According to the World Health Organization (WHO), depressive disorders are currently considered as one of the most disabling medical conditions in the world with one of the highest disability-adjusted life years [1] and this situation has apparently
Externí odkaz:
https://doaj.org/article/d18042db632b47f1bf4bbc245b640a06
Autor:
Katharina Luise Schneider, Melanie Kunst, Ann-Kristin Leuchs, Miriam Böhme, Klaus Weckbecker, Kathrin Kastenmüller, Markus Bleckwenn, Stefan Holdenrieder, Christoph Coch, Gunther Hartmann, Julia Carolin Stingl
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2020)
BackgroundDose requirements of vitamin K antagonists are associated with CYP2C9 and VKORC1, but, compared to warfarin, less data is available about phenprocoumon. Furthermore, the effects on dose stability and anticoagulation quality are still unclea
Externí odkaz:
https://doaj.org/article/1400a9d673574a2892e651ca43b146d3
Publikováno v:
Pharmaceutical Statistics. 16:12-19
Randomized controlled trials (RCTs) aim at providing reliable estimates of treatment benefit. Missing data and nonadherence to treatment are distinct problems that can substantially impede this task. In practice, the fact that the handling of missing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12c71eb253c487c0c0b3bdb8e5a476ad
https://doi.org/10.1002/pst.1791
https://doi.org/10.1002/pst.1791
Publikováno v:
Therapeutic Innovation & Regulatory Science. 49:584-592
Lack of adherence to study protocol and missing data are often unavoidable in clinical trials, and both increase the need to differentiate between the ideal treatment effect if the medication is taken as directed and the treatment effect in presence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d1e58b4973efd470a051a6ea60a0a11
https://doi.org/10.1177/2168479014567317
https://doi.org/10.1177/2168479014567317
Autor:
Ann-Kristin Leuchs, Markus Neuhäuser
Publikováno v:
Journal of Statistical Computation and Simulation. 83:825-836
Protocol amendments are often necessary in clinical trials. They can change the entry criteria and, therefore, the population. Simply analysing the pooled data is not acceptable. Instead, each phase should be analysed separately and a combination tes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bae23c7a2a30f5f17ac1559614fe1f57
https://doi.org/10.1080/00949655.2011.638635
https://doi.org/10.1080/00949655.2011.638635
Autor:
Ann-Kristin Leuchs, Klaus Weckbecker, Christoph Coch, Markus Bleckwenn, Kathrin Kastenmüller, Dorothee Wirtz, Marie-Louise Lehmann, Katrin Claus, Norbert Benda, Katharina Luise Kaumanns, Stefan Holdenrieder, Gunther Hartmann, Michael Steffens, Oliver Schöffski, Julia C. Stingl, Florian Meier
Publikováno v:
BMC Family Practice
Background Elderly patients are particularly vulnerable to adverse drug reactions, especially if they are affected by additional risk factors such as multimorbidity, polypharmacy, impaired renal function and intake of drugs with high risk potential.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80f2470fb8041e66a7a9fd99b0f5996b
http://europepmc.org/articles/PMC4845354
http://europepmc.org/articles/PMC4845354
Publikováno v:
Biometrical Journal. 53:525-534
Lepage's test combines the Wilcoxon rank-sum and the Ansari-Bradley statistics. We propose to replace the latter statistic by a Wilcoxon rank-sum calculated after Levene's transformation. We use the medians for this transformation, i.e. absolute devi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d59a9c1edb69057c6e03045e43e5ed4
https://doi.org/10.1002/bimj.201000162
https://doi.org/10.1002/bimj.201000162
Autor:
Ann-Kristin Leuchs, Manfred Berres, Gabriele Schlosser-Weber, Norbert Benda, Jörg Zinserling, Markus Neuhäuser
Publikováno v:
Statistics in medicine. 33(2)
Treatment non-compliance and missing data are common problems in clinical trials. Non-compliance is a broad term including any kind of deviation from the assigned treatment protocol, such as dose modification, treatment discontinuation or switch, oft
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0cce1785eb58e524092e594e1ec7352
https://pubmed.ncbi.nlm.nih.gov/23873693
https://pubmed.ncbi.nlm.nih.gov/23873693
Publikováno v:
Biometrical journal. Biometrische Zeitschrift. 53(3)
Lepage's test combines the Wilcoxon rank-sum and the Ansari-Bradley statistics. We propose to replace the latter statistic by a Wilcoxon rank-sum calculated after Levene's transformation. We use the medians for this transformation, i.e. absolute devi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d5342884858921d26084b2f5dbbb0678
https://pubmed.ncbi.nlm.nih.gov/22223255
https://pubmed.ncbi.nlm.nih.gov/22223255