Výsledky vyhledávání - "Ann-Ki Pålbrink"

Betahistine prevents development of endolymphatic hydrops in a mouse model of insulin resistance and diabetes

Autor: Ann-Ki Pålbrink, René in ’t Zandt, Måns Magnusson, Eva Degerman

Publikováno v: Acta Oto-Laryngologica. 143:127-133

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::135cc6fbd7298693befeac61b61d758a
https://doi.org/10.1080/00016489.2023.2171116

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Akademický článek

Inner ear is a target for insulin signaling and insulin resistance: evidence from mice and auditory HEI-OC1 cells

Autor: Ann-Ki Pålbrink, Franziska Kopietz, Björn Morén, René In 't Zandt, Federico Kalinec, Karin Stenkula, Olga Göransson, Cecilia Holm, Måns Magnusson, Eva Degerman

Publikováno v: BMJ Open Diabetes Research & Care, Vol 8, Iss 1 (2020)

ObjectiveThe mechanisms underlying the association between diabetes and inner ear dysfunction are not known yet. The aim of the present study is to evaluate the impact of obesity/insulin resistance on inner ear fluid homeostasis in vivo, and to inves

Externí odkaz: https://doaj.org/article/bbae0b4f766e4822b2e19db571a1f2a9

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Insulin regulates Nedd4-2 via a PKB-dependent mechanism in HEI-OC1 auditory cells-crosstalks with sphingolipid and cAMP signaling

Autor: Ann-Ki Pålbrink, Björn Morén, Karin G. Stenkula, Måns Magnusson, Eva Degerman

Publikováno v: Acta oto-laryngologica. 142(1)

The mechanisms of association between diabetes and inner ear dysfunction are unknown, although endolymphatic hydrops may be involved. We have previously shown that insulin signaling components are expressed in human saccule and that insulin signaling

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c0af0433f5d4f786d273bfc2f93b122
https://pubmed.ncbi.nlm.nih.gov/34962430

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Endolymphatic hydrops induced by different mechanisms responds differentially to spironolactone: a rationale for understanding the diversity of treatment responses in hydropic inner ear disease

Autor: Ann-Ki Pålbrink, Måns Magnusson, René in ‘t Zandt, Eva Degerman

Publikováno v: Acta oto-laryngologica. 139(8)

Background: The exact pathophysiological mechanism(s) underlying endolymphatic hydrops (EH) remain elusive. We have previously shown that chronic administration of vasopressin and inhibitors of the cAMP/cGMP degrading enzymes (PDE3, PDE4, PDE5) resul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d20a422de63dc704159207ed286280d3
https://pubmed.ncbi.nlm.nih.gov/31145014

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Inhibition of phosphodiesterase 3, 4, and 5 induces endolymphatic hydrops in mouse inner ear, as evaluated with repeated 9.4T MRI

Autor: Per Cayé-Thomasen, Måns Magnusson, Ann-Ki Pålbrink, Eva Degerman, René in ‘t Zandt, Lena Eliasson

Publikováno v: Acta Oto-Laryngologica. 137:8-15

The data indicate important roles for phosphodiesterase (PDE) 3, 4, 5, and related cAMP and cGMP pools in the regulation of inner ear fluid homeostasis. Thus, dysfunction of these enzymes might contribute to pathologies of the inner ear.The mechanism

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fa9394592524528cc5edaa9efe17ded
https://doi.org/10.1080/00016489.2016.1211320

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Vasopressin induces endolymphatic hydrops in mouse inner ear, as evaluated with repeated 9.4 T MRI

Autor: Ann-Ki Pålbrink, Måns Magnusson, René in ‘t Zandt, Eva Degerman

Publikováno v: Hearing Research; 330(Part A), pp 119-124 (2015)

From histopathological specimens, endolymphatic hydrops has been demonstrated in association with inner ear disorders. Recent studies have observed findings suggestive of hydrops using MRI in humans. Previous studies suggest that vasopressin may play

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89394131475324f5afc2cc02f4521eb8
https://lup.lub.lu.se/record/7487950