Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Ann-Katrin Ball"'
Autor:
Ann-Kathrin Häfner, Kim Beilstein, Philipp Graab, Ann-Katrin Ball, Meike J Saul, Bettina Hofmann, Dieter Steinhilber
Publikováno v:
PLoS ONE, Vol 11, Iss 11, p e0166591 (2016)
Leukotrienes (LTs) are inflammatory mediators that play a pivotal role in many diseases like asthma bronchiale, atherosclerosis and in various types of cancer. The key enzyme for generation of LTs is the 5-lipoxygenase (5-LO). Here, we present a nove
Externí odkaz:
https://doaj.org/article/7493895560534a88bf21a4f54d4a7155
Autor:
Meike J. Saul, Ann-Katrin Ball, Liliana Schaefer, Astrid S. Kahnt, Helena Frey, Rolf Marschalek, Ann-Kathrin Häfner, Dieter Steinhilber, Sandra K. Wittmann, Ricardo Capelo, Frank Schnütgen, Duran Sürün, Nicolas Flamand, Kim Beilstein
Human 5-lipoxygenase (5-LO-WT) initiates the leukotriene (LT) biosynthesis. LTs play an important role in diseases like asthma, atherosclerosis and in many types of cancer. In this study, we investigated the 5-LO isoforms 5-LO∆13, 5-LO∆4 and 5-LO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4799fe1a75325d83376841fbbcfbdcee
https://publica.fraunhofer.de/handle/publica/257315
https://publica.fraunhofer.de/handle/publica/257315
Autor:
Carmela Matrone, Vahid Golghalyani, Isabelle V. Maucher, Michael Rühl, Nadine Hellmuth, Jessica Roos, Matthias Piesche, Ann-Katrin Ball, Michael Karas, Simon B.M. Kretschmer, Ann-Kathrin Häfner, Bettina Hofmann, Georg Manolikakes, Anja Vogel, Benjamin Kühn, Gerd Geisslinger, Thorsten J. Maier, Dieter Steinhilber, Karsten T. Flügel, Jasmin Fettel, Michael J. Parnham
Publikováno v:
Maucher, I V, Rühl, M, Bm Kretschmer, S, Hofmann, B, Kühn, B, Fettel, J, Vogel, A, Flügel, K T, Manolikakes, G, Hellmuth, N, Häfner, A-K, Golghalyani, V, Ball, A-K, Piesche, M, Matrone, C, Geisslinger, G, Parnham, M J, Karas, M, Steinhilber, D, Roos, J & Maier, T J 2017, ' Michael acceptor containing drugs are a novel class of 5-lipoxygenase inhibitor targeting the surface cysteines C416 and C418 ', Biochemical Pharmacology, vol. 125, no. 1, pp. 55–74 . https://doi.org/10.1016/j.bcp.2016.11.004
Recently, we published that nitro-fatty acids (NFA) are potent electrophilic molecules which inhibit 5-lipoxygenase (5-LO) by interacting with catalytically cysteine residues next to a substrate entry channel. The electrophilicity is derived from an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a4ad1c8a0f902beeef1909da6d7f352
https://publica.fraunhofer.de/handle/publica/252024
https://publica.fraunhofer.de/handle/publica/252024
Autor:
Oliver Werz, Ann-Kathrin Häfner, Mirjam Schröder, Ulrike Garscha, Ann-Katrin Ball, Jana Gerstmeier, Sven George, Michael Hörnig, Dieter Steinhilber
Publikováno v:
Biochimica et biophysica acta. 1851(11)
Human 5-lipoxygenase (5-LO) is the key enzyme in the formation of leukotrienes (LTs), important mediators of inflammation. Cellular 5-LO activity is regulated in a complex manner, e.g. by calcium influx, the cellular redox status or 5-LO phosphorylat
Autor:
Bettina Hofmann, Meike J. Saul, Ann-Katrin Ball, Kim Beilstein, Philipp Graab, Ann-Kathrin Häfner, Dieter Steinhilber
Publikováno v:
PLoS ONE, Vol 11, Iss 11, p e0166591 (2016)
PLoS ONE
PLoS ONE
Leukotrienes (LTs) are inflammatory mediators that play a pivotal role in many diseases like asthma bronchiale, atherosclerosis and in various types of cancer. The key enzyme for generation of LTs is the 5-lipoxygenase (5-LO). Here, we present a nove