Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Ann de Mazière"'
Publikováno v:
iScience, Vol 24, Iss 11, Pp 103220- (2021)
Summary: Delivering peptides into cells could open up possibilities for targeting intracellular proteins. Although fatty acylation of peptide therapeutics improves their systemic half-life, it remains unclear how it influences their cellular uptake.
Externí odkaz:
https://doaj.org/article/287ac2a1e17845f6811e652189cbfe08
Autor:
Sam C Nalle, Rosa Barreira da Silva, Hua Zhang, Markus Decker, Cecile Chalouni, Min Xu, George Posthuma, Ann de Mazière, Judith Klumperman, Adriana Baz Morelli, Sebastian J Fleire, Alan S Verkman, E Sergio Trombetta, Matthew L Albert, Ira Mellman
Publikováno v:
PLoS ONE, Vol 15, Iss 11, p e0238484 (2020)
Antigen cross presentation, whereby exogenous antigens are presented by MHC class I molecules to CD8+ T cells, is essential for generating adaptive immunity to pathogens and tumor cells. Following endocytosis, it is widely understood that protein ant
Externí odkaz:
https://doaj.org/article/94af70eb40954a77a1d3ec9f2e7824fe
Autor:
Cathleen A Collins, Ann De Mazière, Suzanne van Dijk, Fredric Carlsson, Judith Klumperman, Eric J Brown
Publikováno v:
PLoS Pathogens, Vol 5, Iss 5, p e1000430 (2009)
Like several other intracellular pathogens, Mycobacterium marinum (Mm) escapes from phagosomes into the host cytosol where it can polymerize actin, leading to motility that promotes spread to neighboring cells. However, only approximately 25% of inte
Externí odkaz:
https://doaj.org/article/74963401a12d4e1e8ad29b8b12d0afef
Autor:
Borislav Dejanovic, Tiffany Wu, Ming-Chi Tsai, David Graykowski, Vineela D. Gandham, Christopher M. Rose, Corey E. Bakalarski, Hai Ngu, Yuanyuan Wang, Shristi Pandey, Mitchell G. Rezzonico, Brad A. Friedman, Rose Edmonds, Ann De Mazière, Raphael Rakosi-Schmidt, Tarjinder Singh, Judith Klumperman, Oded Foreman, Michael C. Chang, Luke Xie, Morgan Sheng, Jesse E. Hanson
Publikováno v:
Nature Aging. 2:837-850
Microglia and complement can mediate neurodegeneration in Alzheimer’s disease (AD). By integrative multi-omics analysis, here we show that astrocytic and microglial proteins are increased in TauP301S synapse fractions with age and in a C1q-dependen
Autor:
Ann De Mazière, Jan van der Beek, Suzanne van Dijk, Cecilia de Heus, Fulvio Reggiori, Masato Koike, Judith Klumperman
Publikováno v:
Autophagy, 18(12), 3004-3022. Taylor & Francis Group
MAP1LC3/LC3 (microtubule associated protein 1 light chain 3) is widely used as marker of autophagic compartments at different stages of maturation. Electron microscopy (EM) combined with immunolabeling is the only technique that can reveal the ultras
Autor:
Nadja S. Katheder, Kristen C. Browder, Diana Chang, Ann De Mazière, Pekka Kujala, Suzanne van Dijk, Judith Klumperman, Zijuan Lai, Dewakar Sangaraju, Heinrich Jasper
Disruption of epithelial barriers is a common disease manifestation in chronic degenerative diseases of the airways, lung and intestine. Extensive human genetic studies have identified risk loci in such diseases, including in chronic obstructive pulm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca74344ffeda3f5181d7eff0ec546b31
https://doi.org/10.1101/2023.02.09.527809
https://doi.org/10.1101/2023.02.09.527809
Publikováno v:
iScience, Vol 24, Iss 11, Pp 103220-(2021)
iScience
iScience
Summary Delivering peptides into cells could open up possibilities for targeting intracellular proteins. Although fatty acylation of peptide therapeutics improves their systemic half-life, it remains unclear how it influences their cellular uptake. H
Autor:
Judith Klumperman, Ngoc-Han Tran, Grant J. Jensen, Avi Ashkenazi, Stephen D. Carter, Peter Walter, Ann De Mazière
Publikováno v:
Science (New York, N.Y.), vol 374, iss 6563
Science
Science
The signaling network of the unfolded protein response (UPR) adjusts the protein-folding capacity of the endoplasmic reticulum (ER) according to need. The most conserved UPR sensor, IRE1α, spans the ER membrane and activates through oligomerization.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7deb363cbe05ad49408945be173ec303
https://escholarship.org/uc/item/4gq267zh
https://escholarship.org/uc/item/4gq267zh
Autor:
David B. Iaea, Rami N. Hannoush, Christopher P. Arthur, Claudio Ciferri, Ann De Mazière, Judith Klumperman, Xinxin Gao
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Scientific Reports
Scientific Reports, 9(1). Nature Publishing Group
Scientific Reports
Scientific Reports, 9(1). Nature Publishing Group
Cystine-knot peptides are attractive templates in drug discovery due to a number of features they possess including their 3D conformation, physicochemical stability and synthetic tractability. Yet, their cellular uptake mechanisms remain largely unex
Autor:
Stephen D. Carter, Judith Klumperman, Avi Ashkenazi, Peter Walter, Ngoc-Han Tran, Ann De Mazière, Grant J. Jensen
The signaling network of the unfolded protein response (UPR) adjusts the protein folding capacity of the endoplasmic reticulum (ER) according to need. The most conserved UPR sensor, IRE1α, spans the ER membrane and activates through oligomerization.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f357903271e8f7aaea0271a5d6c997e
https://doi.org/10.1101/2021.02.24.432779
https://doi.org/10.1101/2021.02.24.432779