Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Ann Vandevelde"'
Autor:
Maarten Gees, Sara Musch, Steven Van der Plas, Anne-Sophie Wesse, Ann Vandevelde, Katleen Verdonck, Oscar Mammoliti, Tzyh-Chang Hwang, Kathleen Sonck, Pieter Stouten, Andrew M. Swensen, Mia Jans, Jan Van der Schueren, Luc Nelles, Martin Andrews, Katja Conrath
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
There is still a high unmet need for the treatment of most patients with cystic fibrosis (CF). The identification and development of new Cystic Fibrosis Transmembrane conductance Regulator (CFTR) modulators is necessary to achieve higher clinical ben
Externí odkaz:
https://doaj.org/article/99852fe337bc4182a943b73d103f71f5
Autor:
Graeme Milligan, Luke Jonathan Alvey, Annick Hagers, Thierry Christophe, Emanuelle Wakselman, Luc Nelles, Line Oste, Steve De Vos, Ann Vandevelde, Katja Conrath, Laurent Saniere, Stephen Robert Fletcher, Laura Jenkins, Sandrine Le Tallec, D. Merciris, Pierre Deprez, Roland Blanque, C. Cottereaux, Romain Luc Marie Gosmini, Ellen van der Aar, Cécile da Costa, Sonia Dupont, Thi Thu Trang Mai, Vanessa Quenehen, Labeguere Frederic Gilbert, Philippe Clément-Lacroix, Florilène Soulas, Reginald Brys, Gregory John Robert Newsome, Nele Vandervoort, Amynata Tirera
Publikováno v:
Journal of Medicinal Chemistry. 63:13526-13545
GPR84 is a medium chain free fatty acid-binding G-protein-coupled receptor associated with inflammatory and fibrotic diseases. As the only reported antagonist of GPR84 (PBI-4050) that displays relatively low potency and selectivity, a clear need exis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a8f803bd9662806c89d70fe1a829f85
https://doi.org/10.1021/acs.jmedchem.0c00272
https://doi.org/10.1021/acs.jmedchem.0c00272
Autor:
Frédéric, Labéguère, Sonia, Dupont, Luke, Alvey, Florilène, Soulas, Gregory, Newsome, Amynata, Tirera, Vanessa, Quenehen, Thi Thu Trang, Mai, Pierre, Deprez, Roland, Blanqué, Line, Oste, Sandrine, Le Tallec, Steve, De Vos, Annick, Hagers, Ann, Vandevelde, Luc, Nelles, Nele, Vandervoort, Katja, Conrath, Thierry, Christophe, Ellen, van der Aar, Emanuelle, Wakselman, Didier, Merciris, Céline, Cottereaux, Cécile, da Costa, Laurent, Saniere, Philippe, Clement-Lacroix, Laura, Jenkins, Graeme, Milligan, Stephen, Fletcher, Reginald, Brys, Romain, Gosmini
Publikováno v:
Journal of medicinal chemistry. 63(22)
GPR84 is a medium chain free fatty acid-binding G-protein-coupled receptor associated with inflammatory and fibrotic diseases. As the only reported antagonist of GPR84 (PBI-4050) that displays relatively low potency and selectivity, a clear need exis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dca817b6050468a00027ab8ce9b149c4
https://pubmed.ncbi.nlm.nih.gov/32902984
https://pubmed.ncbi.nlm.nih.gov/32902984
Autor:
Kathleen Sonck, Mia Jans, Katja Conrath, Ann Vandevelde, Andrew M. Swensen, Pieter F. W. Stouten, Oscar Mammoliti, Maarten Gees, Katleen Verdonck, Steven Emiel Van Der Plas, Anne Sophie Wesse, Jan Van Der Schueren, Luc Nelles, Martin James Inglis Andrews, Sara Musch, Tzyh Chang Hwang
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Frontiers in Pharmacology
Frontiers in Pharmacology
There is still a high unmet need for the treatment of most patients with cystic fibrosis (CF). The identification and development of new Cystic Fibrosis Transmembrane conductance Regulator (CFTR) modulators is necessary to achieve higher clinical ben
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fee33c28983985798adc777f3acffec6
https://www.frontiersin.org/article/10.3389/fphar.2018.01221/full
https://www.frontiersin.org/article/10.3389/fphar.2018.01221/full
Autor:
J.J. Hendrickx, P. Van de Heyning, Kelly Demeester, G. Van Camp, Ann Vandevelde, J. Ben Azza, L. Van Laer, E. Van Eyken
Publikováno v:
Genetic testing
GJB2 (Gap Junction protein beta type 2; Connexin 26, CX26) is known for its contribution to nonsyndromic recessive deafness (NSRD). One particular mutation, 35delG, a deletion of one guanine from a stretch of six leading to a frame shift early in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::867d7cb154cbecd7fbccc2821a289ae4
https://doi.org/10.1089/gte.2006.0528
https://doi.org/10.1089/gte.2006.0528
Publikováno v:
INFORMS Journal on Computing, 17(3), 305-320. INFORMS Institute for Operations Research and the Management Sciences
The multiprocessor flow-shop is the generalization of the flow-shop in which each machine is replaced by a set of identical machines. As finding a minimum-length schedule is NP-hard, we set out to find good lower and upper bounds. The lower bounds ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::692ddd55a69a6db5f0a9a10e6f34ad5a
https://doi.org/10.1287/ijoc.1040.0082
https://doi.org/10.1287/ijoc.1040.0082
Autor:
Adam Dudarewicz, Ann Vandevelde, Marie-Louise Bondeson, A. Wiktorek-Smagur, Annelies Konings, Erik Borg, Mariola Sliwinska-Kowalska, L. Van Laer, G. Van Camp, Jeroen R. Huyghe, Per-Inge Carlsson, Elzbieta Rajkowska, Małgorzata Pawełczyk, Erik Fransen
Publikováno v:
Annals of human genetics
Millions of people are daily exposed to high levels of noise. Consequently, noise-induced hearing loss (NIHL) is one of the most important occupational health hazards worldwide. In this study, we performed an association study for NIHL based on a can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6da70d89c38485607f5459976d7a09a
https://hdl.handle.net/10067/738260151162165141
https://hdl.handle.net/10067/738260151162165141
Autor:
Nils Peeters, Guy Van Camp, Jamila Ben Azza, Wim Wuyts, Alain Goethals, Lut Van Laer, Annelies Konings, Hubert J.M. Smeets, Ann Vandevelde, Els Van Eyken
Publikováno v:
Mitochondrion
Specific mitochondrial DNA (mtDNA) mutations in 12SrRNA and tRNASer(UCN) cause non-syndromic hearing loss (NSHL). In this study, we screened 466 hearing loss (HL) patients, negative for GJB2 mutations, for mutations in the two mtDNA genes and flankin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c23a3889e8cf02f51679c7e238da52c9
https://hdl.handle.net/10067/738610151162165141
https://hdl.handle.net/10067/738610151162165141
Autor:
Guy Van Camp, Nicole C. Meyer, Yasser Riazalhosseini, Mahdi Malekpour, Kimia Kahrizi, Hossein Najmabadi, Ann Vandevelde, Lut Van Laer, Richard J.H. Smith, Fatemeh Alasti, Mahdi Moghannibashi
Publikováno v:
Journal of human genetics
Mutations in DFNA5 lead to autosomal dominant non-syndromic sensorineural hearing loss that starts at the high frequencies. To date, only three DFNA5 mutations have been described, and although different at the genomic DNA level, all lead to exon 8 s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e035310ca2103d5c7feb61e29a8b2f3a
https://hdl.handle.net/10067/644140151162165141
https://hdl.handle.net/10067/644140151162165141
Autor:
Marie-Louise Bondeson, Adam Dudarewicz, Lut Van Laer, Annelies Konings, Guy Van Camp, Erik Borg, Ann Vandevelde, Erik Fransen, Elzbieta Rajkowska, Mariola Sliwinska-Kowalska, Małgorzata Pawełczyk, Per-Inge Carlsson, Jeroen R. Huyghe
Publikováno v:
Human molecular genetics
Noise-induced hearing loss (NIHL) is an important occupational hazard that results from an interaction between genetic and environmental factors. Although the environmental risk factors have been studied quite extensively, little is known about the g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06b17072013a3f0f6707785e1180f8d4
https://hdl.handle.net/10067/650640151162165141
https://hdl.handle.net/10067/650640151162165141