Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Ann V Griffith"'
Autor:
Jerrod L Bryson, Ann V Griffith, Bernard Hughes, Fumi Saito, Yousuke Takahama, Ellen R Richie, Nancy R Manley
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e65196 (2013)
The thymus is composed of multiple stromal elements comprising specialized stromal microenvironments responsible for the development of self-tolerant and self-restricted T cells. Here, we investigated the ontogeny and maturation of the thymic vascula
Externí odkaz:
https://doaj.org/article/15cc795cf1dd450b979af30871e66307
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
One aspect of ageing on immunity is attributed to accelerated thymic atrophy, but the underlying mechanism is still lacking. Here the authors show, using conditional reporter mouse models, that both atrophy and regeneration of the thymus are regulate
Externí odkaz:
https://doaj.org/article/df914271f29b44e993752f1172f879f4
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The thymus is the primary site of T lymphocyte development, where mutually inductive signaling between lymphoid progenitors and thymic stromal cells directs the progenitors along a well-characterized program of differentiation. Although thymic stroma
Externí odkaz:
https://doaj.org/article/6a29a05d8dcf474591b384cd41bb47b9
Autor:
Sergio Cepeda, Carolina Cantu, Stephanie Orozco, Yangming Xiao, Zoe Brown, Manpreet K. Semwal, Thomas Venables, Mark S. Anderson, Ann V. Griffith
Publikováno v:
Cell Reports, Vol 22, Iss 5, Pp 1276-1287 (2018)
Summary: Although autoimmune disorders are a significant source of morbidity and mortality in older individuals, the mechanisms governing age-associated increases in susceptibility remain incompletely understood. Central T cell tolerance is mediated
Externí odkaz:
https://doaj.org/article/2fc1001756ed417bbfa034df07a3b141
Publikováno v:
The Journal of Immunology. 209:950-959
The thymus is a primary lymphoid organ for T cell development. Increasing evidence found that the thymus is also an important site for development of innate lymphoid cells (ILCs). ILCs generated in thymi acquire unique homing properties that direct t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::445efaec613982e3408fcf0d2428a4d3
https://doi.org/10.4049/jimmunol.2100870
https://doi.org/10.4049/jimmunol.2100870
Autor:
Manpreet K. Semwal, Allison K. Hester, Yangming Xiao, Chioma Udeaja, Sergio Cepeda, John S. Verschelde, Nicholas Jones, Sarah A. Wedemeyer, Simon Emtage, Kymberly Wimberly, Ann V. Griffith
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(40)
Thymic stromal cells (TSCs) are critical regulators of T cell tolerance, but their basic biology has remained under-characterized because they are relatively rare and difficult to isolate. Recent work has revealed that constitutive autophagy in TSCs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ff3bb34cdfd01f9c959592a68421b23
https://pubmed.ncbi.nlm.nih.gov/36161925
https://pubmed.ncbi.nlm.nih.gov/36161925
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 209(5)
The thymus is a primary lymphoid organ for T cell development. Increasing evidence found that the thymus is also an important site for development of innate lymphoid cells (ILCs). ILCs generated in thymi acquire unique homing properties that direct t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a6ebb1d99553e2b564ad0a30b8358a54
https://pubmed.ncbi.nlm.nih.gov/35922065
https://pubmed.ncbi.nlm.nih.gov/35922065
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology
Frontiers in Immunology
The thymus is the primary site of T lymphocyte development, where mutually inductive signaling between lymphoid progenitors and thymic stromal cells directs the progenitors along a well-characterized program of differentiation. Although thymic stroma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eeec483a915af7435c738944cd7516d
https://pubmed.ncbi.nlm.nih.gov/33746975
https://pubmed.ncbi.nlm.nih.gov/33746975
Autor:
Allison K. Hester, Manpreet K. Semwal, Sergio Cepeda, Yangming Xiao, Meghan Rueda, Kymberly Wimberly, Thomas Venables, Thamotharampillai Dileepan, Ellen Kraig, Ann V. Griffith
Publikováno v:
Cell Reports. 38:110363
Thymic atrophy reduces naive T cell production and contributes to increased susceptibility to viral infection with age. Expression of tissue-restricted antigen (TRA) genes also declines with age and has been thought to increase autoimmune disease sus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4e80d628b7ae98040406bf4c75cf1be
https://doi.org/10.1016/j.celrep.2022.110363
https://doi.org/10.1016/j.celrep.2022.110363
Autor:
Ann V. Griffith, Sergio Cepeda
Publikováno v:
Experimental Gerontology. 105:113-117
Atrophy of the thymus, the primary site of T lymphocyte generation, is a hallmark of the aging immune system. Age-associated thymic atrophy results in diminished output of new, naïve T cells, with immune sequelae that include diminished responses to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c46b9e4f8985a23fc98ecfa3d5382c5
https://doi.org/10.1016/j.exger.2017.12.022
https://doi.org/10.1016/j.exger.2017.12.022