Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Ann Tovcimak"'
Autor:
Chih-Hung Lee, Ann Tovcimak, Michael W. Decker, Gerard B. Fox, Gricelda H. Simler, Prisca Honore, Jordan W. Brown, Chang Z. Zhu, Madhavi Pai, Nathan R. Rustay, Chih-Liang Chin, Chengmin Zhong, Joe Mikusa, Murali Gopalakrishnan, Victoria A. Komater, Donna M. Gauvin, Anita K. Salyers, Scott J. Baker, La Geisha Lewis, Peer B. Jacobson, Erica Gomez, Prasant Chandran
Publikováno v:
Biochemical Pharmacology. 82:967-976
Positive modulation of the neuronal nicotinic acetylcholine receptor (nAChR) α4β2 subtype by selective positive allosteric modulator NS-9283 has shown to potentiate the nAChR agonist ABT-594-induced anti-allodynic activity in preclinical neuropathi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1340266ffc68c882923bbd524daa5706
https://doi.org/10.1016/j.bcp.2011.05.007
https://doi.org/10.1016/j.bcp.2011.05.007
Autor:
Uwe Müller, Teresa Ellis, Wayne R. Buck, Bradley A. Hooker, Ann Tovcimak, Nathan R. Rustay, Steven C. Cassar, Dancia Scharf, Jeffrey F. Waring, Kevin K.W. Wang, Jinhe Li, Andreas Jeromin, David G. Witte
Publikováno v:
Journal of Neuroscience Methods. 192:249-253
Cerebrospinal fluid (CSF) is commonly used for assessing biomarkers of drug efficacy or disease progression in the central nervous system. Studies of CSF from pre-clinical species can characterize biomarkers for use in clinical trials. However, obtai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d20be3623bbb2039516b3b170c718bbe
https://doi.org/10.1016/j.jneumeth.2010.07.042
https://doi.org/10.1016/j.jneumeth.2010.07.042
Autor:
Vincent P. Hradil, Ann Tovcimak, Anita K. Salyers, Keith B. Ryther, Betty B. Yao, Prisca Honore, Tiffany Runyan Garrison, Bradley A. Hooker, Odile F. El Kouhen, Anthony V. Daza, Gin C. Hsieh, Yihong Fan, Erica J. Wensink, Michael Meyer, Megan E. Gallagher, Gerard B. Fox, Michael J. Dart, Chang Z. Zhu, Madhavi Pai, Chih-Liang Chin, Prasant Chandran, George K. Grayson, Chengmin Zhong
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 328:141-151
Studies demonstrating the antihyperalgesic and antiallodynic effects of cannabinoid CB(2) receptor activation have been largely derived from the use of receptor-selective ligands. Here, we report the identification of A-836339 [2,2,3,3-tetramethyl-cy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32286a3bd2d9d0f847182647c2ed181d
https://doi.org/10.1124/jpet.108.145011
https://doi.org/10.1124/jpet.108.145011
Autor:
Ann Tovcimak, Gin C. Hsieh, Madhavi Pai, Bryan F. Cox, Chih-Liang Chin, Jennifer M. Frost, B B Yao, Michael Meyer, PR Hollingsworth, Donna M. Gauvin, Gerard B. Fox, Prasant Chandran, Chang Z. Zhu, Prisca Honore, T. R. Seifert, Vincent P. Hradil, Jill M. Wetter, Michael J. Dart
Publikováno v:
British Journal of Pharmacology. 153:367-379
Background and purpose: Activation of cannabinoid CB1 and/or CB2 receptors mediates analgesic effects across a broad spectrum of preclinical pain models. Selective activation of CB2 receptors may produce analgesia without the undesirable psychotropic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5551858c313251bee592c203cf440f3
https://doi.org/10.1038/sj.bjp.0707506
https://doi.org/10.1038/sj.bjp.0707506
Autor:
Gerard B. Fox, John D. Beaver, Ann Tovcimak, Jaymin Upadhyay, Michelle Hart, Prisca Honore, Bradley A. Hooker, Rajesh V. Kamath, Rajasimhan Rajagovindan, Scott J. Baker, Joseph P. Mikusa, Prasant Chandran, Anthony Bannon, Michael J. Wald, Shailen K. Joshi, Mark Day, Steven C. Cassar, Jeroen K. Medema
Publikováno v:
NeuroImage. 64
The earliest stages of osteoarthritis are characterized by peripheral pathology; however, during disease progression chronic pain emerges-a major symptom of osteoarthritis linked to neuroplasticity. Recent clinical imaging studies involving chronic p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df2cc6cc0678d447fac77b533d114203
https://pubmed.ncbi.nlm.nih.gov/22982372
https://pubmed.ncbi.nlm.nih.gov/22982372
Publikováno v:
Alzheimer's & Dementia. 6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7187715ae701f6850dc6766362a0cda7
https://doi.org/10.1016/j.jalz.2010.05.1728
https://doi.org/10.1016/j.jalz.2010.05.1728
In vivo efficacy of ABT-255 against drug-sensitive and -resistant Mycobacterium tuberculosis strains
Autor:
Ken Jarvis, L. Paige, Jeffrey Alder, Patty Ewing, Ann Tovcimak, M. Mitten, Mike Nukkula, J. Meulbroek, Andy Oleksijew, Daniel Chu
Publikováno v:
Antimicrobial agents and chemotherapy. 42(10)
Current therapy for pulmonary tuberculosis involves 6 months of treatment with isoniazid, pyrazinamide, rifampin, and ethambutol or streptomycin for reliable treatment efficacy. The long treatment period increases the probability of noncompliance, le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59a1cb8df5ccf1ed759529768c5398fa
https://pubmed.ncbi.nlm.nih.gov/9756775
https://pubmed.ncbi.nlm.nih.gov/9756775
Autor:
Prasant Chandran, Donna M. Gauvin, Gricelda Silmer, Scott J. Baker, Anita K. Salyers, La Geisha R. Lewis, Chih-Liang Chin, Chengmin Zhong, Murali Gopalakrishnan, Ann Tovcimak, Michael W. Decker, Erica J. Wensink, Gerard B. Fox, Chang Z. Zhu, Joe Mikusa, Chih-Hung Lee, Nathan R. Rustay, Prisca Honore, Jordan Brown
Publikováno v:
Biochemical Pharmacology. 78:920
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3cea011b2100cd66c3071729ffc718a
https://doi.org/10.1016/j.bcp.2009.06.082
https://doi.org/10.1016/j.bcp.2009.06.082