Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Ann Thanawastien"'
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 15, Iss 6, Pp 1310-1316 (2019)
Typhax is an investigational typhoid fever vaccine candidate that was GMP manufactured applying Protein Capsular Matrix Vaccine (PCMV) technology. It consists of Vi polysaccharide antigen, derived from S. Typhi, non-covalently entrapped in a glutaral
Externí odkaz:
https://doaj.org/article/fbfd1a19c87b421c8195c1660aafc381
Autor:
Robert T Cartee, Ann Thanawastien, Thomas J Griffin Iv, John J Mekalanos, Stephan Bart, Kevin P Killeen
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 1, p e0007912 (2020)
BACKGROUND:Typhoid fever remains a significant cause of morbidity and mortality in developing countries especially in children ≤5 years old. Although the widely available unconjugated Vi polysaccharide vaccines are efficacious, they confer limited,
Externí odkaz:
https://doaj.org/article/2a50a6751c374121b9263e76863bbf71
Publikováno v:
PLoS Pathogens, Vol 5, Iss 8, p e1000556 (2009)
Recognition of conserved bacterial components provides immediate and efficient immune responses and plays a critical role in triggering antigen-specific adaptive immunity. To date, most microbial components that are detected by host innate immune sys
Externí odkaz:
https://doaj.org/article/6c1f469145664a77af9243f261ca0034
Autor:
Yoshikazu, Honda-Okubo, Robert T, Cartee, Ann, Thanawastien, Jae, Seung Yang, Kevin P, Killeen, Nikolai, Petrovsky
Publikováno v:
Vaccine. 40:4625-4634
Typhax is an investigational typhoid fever vaccine candidate that is comprised of Vi polysaccharide from Salmonella enterica serovar typhi (S. Typhi) non-covalently entrapped in a glutaraldehyde catalyzed, cross-linked α-poly-L-lysine and CRM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbe465c33702d28cf17d979507a89094
https://doi.org/10.1016/j.vaccine.2022.06.043
https://doi.org/10.1016/j.vaccine.2022.06.043
Autor:
Rodney K. Tweten, Robert T. Cartee, Laurel A. Haines, Stephen I. Pelton, Ann Thanawastien, Kevin P. Killeen, Kelsey E. Joyce
Publikováno v:
Vaccine
Pneumolysin is a highly conserved, cholesterol-dependent cytolysin that is an important Streptococcus pneumoniae virulence factor and an attractive target for vaccine development. To attenuate pneumolysin toxicity, a genetic toxoid was constructed wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7301ed964fc47b86ee5939bb3b0bd45
http://europepmc.org/articles/PMC8237519
http://europepmc.org/articles/PMC8237519
Autor:
John J. Mekalanos, Kevin P. Killeen, Robert T. Cartee, Thomas J. Griffin, Stephan Bart, Ann Thanawastien
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 1, p e0007912 (2020)
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases
Background Typhoid fever remains a significant cause of morbidity and mortality in developing countries especially in children ≤5 years old. Although the widely available unconjugated Vi polysaccharide vaccines are efficacious, they confer limited,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee109d7f67a1121f7283b7faf43bd700
https://doaj.org/article/2a50a6751c374121b9263e76863bbf71
https://doaj.org/article/2a50a6751c374121b9263e76863bbf71
Publikováno v:
Hum Vaccin Immunother
Typhax is an investigational typhoid fever vaccine candidate that was GMP manufactured applying Protein Capsular Matrix Vaccine (PCMV) technology. It consists of Vi polysaccharide antigen, derived from S. Typhi, non-covalently entrapped in a glutaral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2225f58ad18f522007534cb7c4f5f856
https://pubmed.ncbi.nlm.nih.gov/31021700
https://pubmed.ncbi.nlm.nih.gov/31021700
Capsular polysaccharides are the primary antigenic components involved in protective immunity against encapsulated bacterial pathogens. Although immunization of adolescents and adults with polysaccharide antigens has reduced pathogen disease burden,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::313577a7d8e6b1d59143a7dfe6c093e7
https://europepmc.org/articles/PMC4364189/
https://europepmc.org/articles/PMC4364189/
Publikováno v:
Vaccine. 18:1944-1951
LT(R192G) is a novel mucosal adjuvant that induces protective immunity when co-administered with certain whole inactivated bacteria or viruses or with subunits of relevant virulence determinants from these pathogens. LT(R192G) stimulates antigen-spec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1126e214cb62807f019e175fe57ab36
https://doi.org/10.1016/s0264-410x(99)00447-8
https://doi.org/10.1016/s0264-410x(99)00447-8
Publikováno v:
Vaccine. 20(1-2)
Although Tat-specific CTL responses are elicited in HIV-infected patients and in non-human primate models, specific CTL epitopes within Tat have not been identified. In this study, we mucosally immunized mice with recombinant, full-length Tat protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caea9f9003a31a6206b1cddc7260eb5b
https://pubmed.ncbi.nlm.nih.gov/11567739
https://pubmed.ncbi.nlm.nih.gov/11567739