Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Ann T, Doherty"'
Autor:
Edward J. Hennessy, Marianne Schimpl, Emma Rivers, Paul D. Smith, Elizabeth Hardaker, Ann T. Doherty, Nichola L. Davies, Jon Travers, Qianxiu Zhu, Beth Williamson, Graham Smith, Lorraine Mooney, Helen Musgrove, Kristin Goldberg, Muireann Coen, Anne-Laure Lainé, Xiefeng Jiang, Philip Hopcroft, Yuting Zheng, Robert I Troup, George Hodgson, Nicola Lindsay, Lindsay McMurray, Olga Collingwood, Stephen D. Wilkinson, Sharon Tentarelli, Guang He, Philip B. Rawlins, Roshini Markandu, Jon Winter-Holt, Josephine Walton, Ankur Karmokar, J. Willem M. Nissink, Yumeng Mao, Dejian Yang, Alexander Pflug, Gary Fairley, Scott Boyd, Cheng Wang, Anne Jackson, Martin R. Brown, William McCoull, Neville McLean, Venkatesh Pilla Reddy
Publikováno v:
Journal of Medicinal Chemistry. 64:13524-13539
Inhibition of Mer and Axl kinases has been implicated as a potential way to improve the efficacy of current immuno-oncology therapeutics by restoring the innate immune response in the tumor microenvironment. Highly selective dual Mer/Axl kinase inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae4c719e098004f12a5992670f8e8abc
https://doi.org/10.1021/acs.jmedchem.1c00920
https://doi.org/10.1021/acs.jmedchem.1c00920
Autor:
Amy Wilson, Ann T. Doherty, Joanne M Elloway, Piotr Grabowski, Jonathan Stott, Stephanie Ling
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports
Scientific Reports
To provide a comprehensive analysis of small molecule genotoxic potential we have developed and validated an automated, high-content, high throughput, image-based in vitro Micronucleus (IVM) assay. This assay simultaneously assesses micronuclei and m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dbaeb3401dceed1bbb2062a14287d1b
https://doaj.org/article/734ce7250fa54c68a6acc32cb4966de1
https://doaj.org/article/734ce7250fa54c68a6acc32cb4966de1
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Micronucleus (MN) assessment is a valuable tool in safety assessment. However, several compounds are positive in the in vivo bone marrow (BM) MN assay but negative in vitro, reflecting that BM complexity is not recapitulated in vitro. Importantly, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b13b34e8e67db6b2bf5e23d62cb5e90
https://pubmed.ncbi.nlm.nih.gov/34754012
https://pubmed.ncbi.nlm.nih.gov/34754012
Autor:
Ann T. Doherty, George E. Johnson, Fiona M. Chapman, Katherine E. Chapman, Jatin R. Verma, Eleanor C. Wilde, James A. Tonkin, Leanne M. Stannard, Gareth J.S. Jenkins, M. Rowan Brown, Ume-Kulsoom Shah, Anna L. Seager, Shareen H. Doak
Publikováno v:
Archives of Toxicology
Current in vitro genotoxicity tests can produce misleading positive results, indicating an inability to effectively predict a compound’s subsequent carcinogenic potential in vivo. Such oversensitivity can incur unnecessary in vivo tests to further
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57a23b0c49eed7468aa74bcdecf69813
https://cronfa.swan.ac.uk/Record/cronfa55186/Download/55186__18359__b5f156f08e5d4ed9bbdcc8a37f5027bb.pdf
https://cronfa.swan.ac.uk/Record/cronfa55186/Download/55186__18359__b5f156f08e5d4ed9bbdcc8a37f5027bb.pdf
Autor:
George E. Johnson, Katherine E. Chapman, Katja Brüsehafer, Gareth J.S. Jenkins, M. Rowan Brown, Jatin R. Verma, Ume-Kulsoom Shah, Leanne M. Stannard, Eleanor C. Wilde, Shareen H. Doak, Anna L. Seager, James A. Tonkin, Ann T. Doherty
Publikováno v:
Archives of Toxicology
Human exposure to carcinogens occurs via a plethora of environmental sources, with 70–90% of cancers caused by extrinsic factors. Aberrant phenotypes induced by such carcinogenic agents may provide universal biomarkers for cancer causation. Both cu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b0d5058ecc28a1ac7797ee5faa9135b
https://doi.org/10.1007/s00204-017-2102-y
https://doi.org/10.1007/s00204-017-2102-y
Autor:
Véronique Thybaud, Jos C. S. Kleinjans, Jason H. Bielas, Paul D. White, Francesco Marchetti, Ann T. Doherty, Carole L. Yauk, Yukari Totsuka, Masamitsu Honma, Stephen D. Dertinger, Maik Schuler
Publikováno v:
Mutation Research-Genetic Toxicology and Environmental Mutagenesis, 847:403022. Elsevier
We live in an era of 'big data', where the volume, velocity, and variety of the data being generated is increasingly influencing the way toxicological sciences are practiced. With this in mind, a workgroup was formed for the 2017 International Worksh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27461b869153a353989033b9ace5dc28
https://cris.maastrichtuniversity.nl/en/publications/5048cbc7-b2c9-4c7d-9d8b-e91ce6bceeda
https://cris.maastrichtuniversity.nl/en/publications/5048cbc7-b2c9-4c7d-9d8b-e91ce6bceeda
Autor:
Rhiannon David, Ann T. Doherty
Publikováno v:
Toxicological Sciences. 155:315-325
Viral vector use in gene therapy has highlighted several safety concerns, including genotoxic events. Generally, vector-mediated genotoxicity results from upregulation of cellular proto-oncogenes via promoter insertion, promoter activation, or gene t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc2fe744cae3c5666144f9069eef18c9
https://doi.org/10.1093/toxsci/kfw220
https://doi.org/10.1093/toxsci/kfw220
Autor:
Ann T. Doherty, Leon F. Stankowski, Jennifer Y. Tanir, Julia Kenny, Tao Chen, Brinda Mahadevan, Marilyn J. Aardema, Martha M. Moore, Gladys Ouedraogo, Christopher S Farabaugh, Shareen H. Doak, Mugimane G. Manjanatha, Stefan Pfuhler, Rosalie K. Elespuru
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 164(2)
Nanomaterials (NMs) present unique challenges in safety evaluation. An international working group, the Genetic Toxicology Technical Committee of the International Life Sciences Institute's Health and Environmental Sciences Institute, has addressed i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97296c11d2d4f40a1d253222244346c9
https://pubmed.ncbi.nlm.nih.gov/29701824
https://pubmed.ncbi.nlm.nih.gov/29701824
Autor:
Ulla Plappert-Helbig, M.R. O'Donovan, Bas-jan van der Leede, Jonathan Howe, Ann T. Doherty, Véronique Thybaud, Melanie Guérard
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. :81-88
In genotoxicity testing of pharmaceuticals the rodent alkaline comet assay is being increasingly used as a second in vivo assay in addition to the in vivo micronucleus assay to mitigate in vitro positive results as recommended by the ICH S2(R1) guide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0112deaefb71a1dc796660e5aeda3c98
Publikováno v:
Archives of toxicology. 92(4)
A recent flow cytometry-based in vivo mutagenicity assay involves the hemizygous phosphatidylinositol class A (Pig-a) gene. Pig-a forms the catalytic subunit of N-acetylglucosaminyltransferase required for glycophosphatidylinositol (GPI) anchor biosy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39429fb69fbd4e3f8eb054c53b39d31a
https://pubmed.ncbi.nlm.nih.gov/29362862
https://pubmed.ncbi.nlm.nih.gov/29362862