Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Ann S. Heiman"'
Publikováno v:
Cytokine
Trafficking and inflammation in airway diseases are, in part, modulated by members of the CC chemokine family, eotaxin-1 (CCL11), eotaxin-2 (CCL24), and eotaxin-3 (CCL26), which transduce signals through their CCR3 receptor. In this context, we hypot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5df82d2359192ad7965b74d5558f50c0
Publikováno v:
Cytokine. 36:237-244
Airway epithelial inflammation associated with emphysema, chronic bronchitis, chronic obstructive pulmonary disease (COPD) and asthma is regulated in part by alveolar type II cell chemokine signaling. Data suggest that resident lung cells use CCR3, C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f501824b8ea5ed634b8e8084d832b46
https://doi.org/10.1016/j.cyto.2007.01.001
https://doi.org/10.1016/j.cyto.2007.01.001
Publikováno v:
Steroids. 71:83-89
In continuing efforts to develop potent anti-inflammatory steroids without systemic adverse effects, methyl 9alpha-fluoro-11beta,17alpha,21-trihydroxy-3,20-dioxo-pregna-1,4-diene-16alpha-carboxylate (FP16CM) and its 16-alkoxycarbonyl derivatives (FP1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2ebb219c378f5ebefadf20f95f05d8a
https://doi.org/10.1016/j.steroids.2005.08.005
https://doi.org/10.1016/j.steroids.2005.08.005
Publikováno v:
Experimental Biology and Medicine. 227:645-651
Eosinophilic leukocytes have been implicated as primary effector cells in inflammatory and allergic diseases. When activated by cytokines, human eosinophils secrete and produce a variety of proinflammatory or tissue damaging substances. Although well
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::361a823a2c3acbbd52df9e681220fe41
https://doi.org/10.1177/153537020222700814
https://doi.org/10.1177/153537020222700814
Publikováno v:
Steroids. 65:210-218
To a series of 21-desoxy-21-chloro-corticosteroids, a metabolically labile methoxycarbonyl group at C-16 has been incorporated. The approach is to synthesize locally active compounds that are hydrolyzed to inactive and readily excretable acid metabol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e3959c55cd258f05e83d2b88da5cefd
https://doi.org/10.1016/s0039-128x(99)00103-8
https://doi.org/10.1016/s0039-128x(99)00103-8
Autor:
Ann S. Heiman, Diane Allen-Gipson
Publikováno v:
International Journal of Immunopharmacology. 22:171-181
The eosinophilic (EOS) leukocyte has been implicated as a primary effector cell in inflammatory and allergic diseases. Cytokines are among the mediators of inflammatory and allergic diseases which modulate the effector functions of EOS. Certain cytok
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22b940b84b8e6b06aabba5a2d3bbca0d
https://doi.org/10.1016/s0192-0561(99)00075-2
https://doi.org/10.1016/s0192-0561(99)00075-2
Regulation of 10P2 Murine Mast Cell Proliferation and Secretory Function by Stem Cell Factor or IL-9
Publikováno v:
Experimental Biology and Medicine. 217:439-444
Mast cells are effectors of inflammatory responses. When triggered by immunological or nonimmunological mechanisms, mast cells release potent biological mediators from preformed stores and synthesize others de novo. In previous investigations from th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4afec563e2017c0fab2d976ad1a85016
https://doi.org/10.3181/00379727-217-44254
https://doi.org/10.3181/00379727-217-44254
Publikováno v:
Steroids. 62:491-499
Focused efforts have been made to increase local-to-systemic activity ratios of potent anti-inflammatory steroids for local and/or topical applications. The approach taken in the present investigation is based upon the concept of "antedrug," defined
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36b91c3034e962a3d1d883b673d2410c
https://doi.org/10.1016/s0039-128x(97)00020-2
https://doi.org/10.1016/s0039-128x(97)00020-2
Autor:
Ann S. Heiman, Lisa E. Tonner
Publikováno v:
Toxicology. 119:155-166
Specific cellular sites of lead action have not been completely defined. To elucidate the effects of lead exposure on glucocorticoid-mediated signal transduction in hepatic hormonal target tissues, the induction of tyrosine aminotransferase (TAT) spe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56f75170c36a6d0b2e656cf426005a2a
https://doi.org/10.1016/s0300-483x(97)03620-2
https://doi.org/10.1016/s0300-483x(97)03620-2
Publikováno v:
Journal of Medicinal Chemistry. 38:1048-1051
Novel steroidal antiinflammatory antedrugs, 11 beta,20-dihydroxy-3,20-dioxo-3'-(ethoxycarbonyl)-isoxazolino[16,17 - d]pregna-1,4-diene (2a) and 9-fluoro-11 beta,20-dihydroxy-3,20-dioxo-3'-ethoxy- carbonylisoxazolino[16,17-d]pregna-1,4-diene (2b) were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66552746090ea8e4a2bf9a761d02fa11
https://doi.org/10.1021/jm00006a026
https://doi.org/10.1021/jm00006a026