Recombinant protein subunit SARS-CoV-2 vaccines formulated with CoVaccine HT adjuvant induce broad, Th1 biased, humoral and cellular immune responses in mice.

Autor: Lai CY; Department of Tropical Medicine, Medical Microbiology, and Pharmacology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI, USA.; Pacific Center for Emerging Infectious Disease Research, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI, USA., To A; Department of Tropical Medicine, Medical Microbiology, and Pharmacology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI, USA., Ann S Wong T; Department of Tropical Medicine, Medical Microbiology, and Pharmacology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI, USA., Lieberman MM; Department of Tropical Medicine, Medical Microbiology, and Pharmacology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI, USA., Clements DE; Hawaii Biotech, Inc., Honolulu, HI, USA., Senda JT; Hawaii Biotech, Inc., Honolulu, HI, USA., Ball AH; Department of Tropical Medicine, Medical Microbiology, and Pharmacology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI, USA., Pessaint L; Bioqual Inc., Rockville, MD, USA., Andersen H; Bioqual Inc., Rockville, MD, USA., Furuyama W; Laboratory of Virology, Division of Intramural Research, NIAID, NIH, Hamilton, Montana, MT, USA., Marzi A; Laboratory of Virology, Division of Intramural Research, NIAID, NIH, Hamilton, Montana, MT, USA., Donini O; Soligenix, Inc, Princetown, NJ, USA., Lehrer AT; Department of Tropical Medicine, Medical Microbiology, and Pharmacology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI, USA.; Pacific Center for Emerging Infectious Disease Research, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI, USA.

Publikováno v: Vaccine: X [Vaccine X] 2021 Nov 05, pp. 100126. Date of Electronic Publication: 2021 Nov 05.