Zobrazeno 1 - 10
of 115
pro vyhledávání: '"Ann Rowley"'
Autor:
Ann Rowley, Brian S. Brown, Mary Stofega, Hana Hoh, Rebecca Mathew, Violeta Marin, Rong-Xian Ding, Ryan A. McClure, Fabiola M. Bittencourt, Jun Chen, Tarikere Gururaja, Taisei Kinoshita, Xueqing Wang, Alexey Rivkin, Kevin R. Woller
Publikováno v:
ACS Chemical Biology. 17:1315-1320
Interleukin-1 receptor-associated kinase 3 (IRAK3) is a pseudokinase mediator in the human inflammatory pathway, and ablation of its function is associated with enhanced antitumor immunity. Traditionally, pseudokinases have eluded "druggability" and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e2f2e73fadcb90f2612c80b7aef09fe
https://doi.org/10.1021/acschembio.2c00037
https://doi.org/10.1021/acschembio.2c00037
Autor:
Daniela Masi, Keila N. Crespo-Llado, Amanda K. Lukens, Roger C. Wiegand, Dyann F. Wirth, Ann Rowley, Jeremy R. Duvall, Richard W. Heidebrecht, Mark E. Fitzgerald, Michael Foley, Adelfa E. Serrano, Nobutaka Kato, Stuart L. Schreiber, Marion Mercier, Benito Munoz, Carol A. Mulrooney, Christina Scherer, Eamon Comer, Maurice D. Lee, Michelle Palmer, Giovanni Muncipinto, Jennifer A. Beaudoin
Publikováno v:
Journal of Medicinal Chemistry
Here, we describe medicinal chemistry that was accelerated by a diversity-oriented synthesis (DOS) pathway, and in vivo studies of our previously reported macrocyclic antimalarial agent that derived from the synthetic pathway. Structure–activity re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f0a1ed1bf52387b6cc5aab71452f65c
http://europepmc.org/articles/PMC4207553
http://europepmc.org/articles/PMC4207553
Autor:
Carol A. Mulrooney, Morgan Welzel-O’Shea, Bérénice C. Lemercier, Edward B. Holson, Landon Durak, Sarathy Kesavan, Jeremy R. Duvall, Jingqiang Wei, Florence F. Wagner, Adrien Joliton, Laura M. Panko, Maurice D. Lee, Lisa A. Marcaurelle, Lakshmi B. Akella, Haibo Liu, Emeline L. Davoine, Jason T. Lowe, Méryl Thomas, Etienne J. Donckele, Michael Foley, Byung-Chul Suh, Giovanni Muncipinto, Ann Rowley, Jean-Charles Marie, Baudouin Gerard
Publikováno v:
The Journal of Organic Chemistry. 77:7187-7211
The synthesis and diversification of a densely functionalized azetidine ring system to gain access to a wide variety of fused, bridged, and spirocyclic ring systems is described. The in vitro physicochemical and pharmacokinetic properties of represen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8203c3d71af27e48bd78615da92d79b3
https://doi.org/10.1021/jo300974j
https://doi.org/10.1021/jo300974j
Autor:
Troy D. Ryba, Maurice D. Lee, Stephen J. Haggarty, Surya A. Reis, Eamon Comer, Nathan T. Ross, Jingqiang Wei, Byung-Chul Suh, Michael Foley, Lakshmi B. Akella, Haibo Liu, Jason T. Lowe, Yan-Ling Zhang, Wen-Ning Zhao, Jeremy R. Duvall, Daniel M. Fass, Damian W. Young, Carol Mulrooney, Lisa A. Marcaurelle, Bhaumik A. Pandya, Ann Rowley, Michelle Palmer, Baudouin Gerard, Sivaraman Dandapani, Sarathy Kesavan, Jean-Charles Marie
Publikováno v:
Journal of the American Chemical Society. 132:16962-16976
An aldol-based ‘build/couple/pair’ (B/C/P) strategy was applied to generate a collection of stereochemically and skeletally diverse small molecules. In the build phase, a series of asymmetric syn- and anti- aldol reactions were performed to produ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c575c3dd482cf0fdfd0443c446a3da8
https://doi.org/10.1021/ja105119r
https://doi.org/10.1021/ja105119r
Autor:
Marie Harton, Carol A. Mulrooney, Michael Dombrowski, Sivaraman Dandapani, Troy D. Ryba, Bhaumik A. Pandya, Jeremy R. Duvall, Ann Rowley, Damian W. Young, Lisa A. Marcaurelle
Orthogonally protected chiral β-hydroxy-γ-amino acids can be accessed in >100 g quantities from readily available starting materials and reagents in 3-4 steps. These chiral synthons contain two adjacent stereocenters along with suitably protected f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e619990768c8d08db0d81ca04f16f169
https://europepmc.org/articles/PMC3150486/
https://europepmc.org/articles/PMC3150486/
Publikováno v:
ChemInform. 40
Enantioenriched pyranones are important intermediates in the synthesis of natural products and the generation of compound libraries. A one-pot method for their synthesis is outlined. Catalytic asymmetric alkylation of 2-furfurals in the presence of c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69b48bfecc60d0d62cbd73891f1a0c8b
https://doi.org/10.1002/chin.200946141
https://doi.org/10.1002/chin.200946141
Autor:
Sarathy Kesavan, Jean-Charles Marie, Ann Rowley Kelly, Jingqiang Wei, Damian W. Young, Lisa A. Marcaurelle, Nicole Windmon
Publikováno v:
ChemInform. 40
A regioselective intramolecular Huisgen cycloaddition was performed on various azido alkyne substrates giving rise to macrocyclic triazole rings. Using catalyst control, a common intermediate has been converted to two structurally unique macrocycles
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ebf59d8c07e3bd02ef885d203e07f6e4
https://doi.org/10.1002/chin.200944164
https://doi.org/10.1002/chin.200944164
Enantioenriched pyranones are important intermediates in the synthesis of natural products and the generation of compound libraries. A one-pot method for their synthesis is outlined. Catalytic asymmetric alkylation of 2-furfurals in the presence of c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e7e622764f00cd2ab9c76f64965985a
https://europepmc.org/articles/PMC2709820/
https://europepmc.org/articles/PMC2709820/
Autor:
Ann Rowley Kelly, Jean-Charles Marie, Nicole Windmon, Sarathy Kesavan, Lisa A. Marcaurelle, Damian W. Young, Jingqiang Wei
A regioselective intramolecular Huisgen cycloaddition was performed on various azido alkyne substrates giving rise to macrocyclic triazole rings. Using catalyst control, a common intermediate has been converted to two structurally unique macrocycles
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::005bbdebbc96392e09eadca68120ff37
https://europepmc.org/articles/PMC2702139/
https://europepmc.org/articles/PMC2702139/
Publikováno v:
ChemInform. 39
Furans and pyrroles are important synthons in chemical synthesis and are commonly found in natural products, pharmaceutical agents, and materials. Introduced herein are three methods to prepare 2-substituted 3-furfurals starting from 3-furfural, 3-br
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a26f6770e9a3aea8f6577967d19da9d
https://doi.org/10.1002/chin.200832103
https://doi.org/10.1002/chin.200832103