Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Ann Roman"'
Publikováno v:
PLoS Pathogens, Vol 15, Iss 1, p e1007543 (2019)
Merkel cell polyomavirus (MCPyV) accounts for 80% of all Merkel cell carcinoma (MCC) cases through expression of two viral oncoproteins: the truncated large T antigen (LT-t) and small T antigen (ST). MCPyV ST is thought to be the main driver of cellu
Externí odkaz:
https://doaj.org/article/4f1b05a618834a218d950755a744d4d6
Publikováno v:
Journal of Investigative Dermatology. 142:2838
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db4f9658cf1ea5aa810582de71d4b040
https://doi.org/10.1016/j.jid.2022.08.012
https://doi.org/10.1016/j.jid.2022.08.012
Autor:
Roberto Martin Huertas, Ruth Ann Roman, Miguel F. Sanmamed, Miguel Angel Molina Vila, Eva Muñoz-Couselo, Ana Arance, Ivan Marquez-Rodas, Javier Sánchez López, Stéphane Dalle, Angel Alberich-Bayarri, Delvys Rodriguez-Abreu, Maria Gonzalez-Cao, Sonia Maciá, Juan Francisco Rodriguez-Moreno, Marya F. Chaney, Irene Mayorga-Ruiz, Pablo Cerezuela-Fuentes, Marisol Quintero, Juan Martin-Liberal, Eduardo Castanon
Publikováno v:
Journal of Clinical Oncology. 39:TPS9586-TPS9586
TPS9586 Background: Intratumoral immunotherapies are gaining interest in oncology, particularly in melanoma. These therapies, however, have faced some issues. For instance, standard response criteria do not accurately describe tumor burden, and respo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8bced75d81f33add953ebd2c17086317
https://doi.org/10.1200/jco.2021.39.15_suppl.tps9586
https://doi.org/10.1200/jco.2021.39.15_suppl.tps9586
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 15, Iss 1, p e1007543 (2019)
PLoS Pathogens, Vol 15, Iss 1, p e1007543 (2019)
Merkel cell polyomavirus (MCPyV) accounts for 80% of all Merkel cell carcinoma (MCC) cases through expression of two viral oncoproteins: the truncated large T antigen (LT-t) and small T antigen (ST). MCPyV ST is thought to be the main driver of cellu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0c9c5258d920969e2e8ea61b40bcbd7
https://pubmed.ncbi.nlm.nih.gov/30689667
https://pubmed.ncbi.nlm.nih.gov/30689667
Autor:
Xiaojie Qi, Matthew D. Daugherty, Ann Roman, Denise A. Galloway, Harmit S. Malik, Kristin L. Robinson, Anjali Bheda-Malge, Joseph J. Carter, Gregory C. Wipf
Publikováno v:
Proceedings of the National Academy of Sciences. 110:12744-12749
Many viruses use overprinting (alternate reading frame utilization) as a means to increase protein diversity in genomes severely constrained by size. However, the evolutionary steps that facilitate the de novo generation of a novel protein within an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::204e0739c40d33a63616f3bfe5059e45
https://doi.org/10.1073/pnas.1303526110
https://doi.org/10.1073/pnas.1303526110
Autor:
Brenna Benson, Ramon Chua, Teresa S. Rasalan, James P. Allison, Michael A. Postow, Yoshiya Yamada, Ruth Ann Roman, Samuel Rosner, Erika Ritter, Margaret K. Callahan, Christopher A. Barker, Matthew Adamow, Arvin Yang, Jianda Yuan, Shigehisa Kitano, Jedd D. Wolchok, Christine Sedrak, Achim A. Jungbluth, Alexander M. Lesokhin, Sacha Gnjatic, Zhenyu Mu
Publikováno v:
New England Journal of Medicine. 366:925-931
The abscopal effect is a phenomenon in which local radiotherapy is associated with the regression of metastatic cancer at a distance from the irradiated site. The abscopal effect may be mediated by activation of the immune system. Ipilimumab is a mon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::247972204ad22d55f23934eacd80c893
https://doi.org/10.1056/nejmoa1112824
https://doi.org/10.1056/nejmoa1112824
Autor:
Ruth-Ann Roman
Publikováno v:
Clinical Journal of Oncology Nursing. 15:E58-E65
The anticytotoxic T-lymphocyte antigen-4 (CTLA-4) monoclonal antibody ipilimumab was approved recently by the U.S. Food and Drug Administration for the treatment of patients with unresectable or metastatic melanoma. Anti-CTLA-4 treatment yields tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc8cf19f2224cc9f421d32c6db32fd94
https://doi.org/10.1188/11.cjon.e58-e65
https://doi.org/10.1188/11.cjon.e58-e65
Publikováno v:
Virology. 410:283-290
Tumor suppressors negatively regulate angiogenesis, an essential step in tumor progression. Together, HPV 16 E6 and E7 proteins, which target p53 and pRb family members, respectively, for degradation, increase the expression of two angiogenic inducer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0496fff9da6cfd97a1e51c8746184a28
https://doi.org/10.1016/j.virol.2010.11.010
https://doi.org/10.1016/j.virol.2010.11.010
Autor:
Teresa S. Rasalan, Paul B. Chapman, Ruth-Ann Roman, Humilidad F. Gallardo, Alan N. Houghton, Gary K. Schwartz, Jedd D. Wolchok, Katherine S. Panageas, Sapna Tandon, Zhenyu Mu, Stephanie L. Terzulli, Barrett B. Bewkes, Matthew Adamow, Jianda Yuan, Brian A. Ginsberg, Richard D. Carvajal
Publikováno v:
Clinical Cancer Research. 16:4057-4065
Purpose: Prior studies show that i.m. injection of xenogeneic orthologues of melanosomal antigens (tyrosinase, gp100) induces CD8+ T-cell responses to the syngeneic protein. To further define the optimal vaccination strategy, we conducted a pilot cli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4364022ddcdb933289a98ebc80ed6a8f
https://doi.org/10.1158/1078-0432.ccr-10-1093
https://doi.org/10.1158/1078-0432.ccr-10-1093