Výsledky vyhledávání - "Ann R, Holmes"

Adhesion of Yeast and Bacteria to Oral Surfaces

Autor: Richard D, Cannon, Karl M, Lyons, Kenneth, Chong, Kathryn, Newsham-West, Kyoko, Niimi, Ann R, Holmes

Publikováno v: Methods in molecular biology (Clifton, N.J.). 2588

Colonization of surfaces in the human body by microorganisms is an early, essential, step in the initiation of infectious disease. We have developed in vitro assays to investigate interactions between yeast or bacterial cells and human tissues, fluid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::9a38b74f6489dcbba2ba8d4ac3c15b4a
https://pubmed.ncbi.nlm.nih.gov/36418686

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Candida albicans Bgl2p, Ecm33p, and Als1p proteins are involved in adhesion to saliva-coated hydroxyapatite

Autor: Richard D. Cannon, Takahiro Oura, Ann R. Holmes, Susumu Kajiwara, Rouyu Zhang, Xinyue Chen, Shun Iwatani, Hoa Thanh Nguyen, Kyoko Niimi, Masakazu Niimi, Naoki Inokawa

Publikováno v: Journal of Oral Microbiology, Vol 13, Iss 1 (2021)
Journal of Oral Microbiology
article-version (VoR) Version of Record

Introduction: Candida albicans is an opportunistic pathogen that causes oral candidiasis. A previous study showed that Bgl2p and Ecm33p may mediate the interaction between the yeast and saliva-coated hydroxyapatite (SHA; a model for the tooth surface

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b75bbdd3f476b7c40d918dcebe8b118f
https://doaj.org/article/a441a4555dc94645989a6b75111a9e56

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Targeting efflux pumps to overcome antifungal drug resistance

Autor: Irena Ivnitski-Steele, Brian C. Monk, Kurt Lackovic, Richard D. Cannon, J. Jacob Strouse, Mikhail V. Keniya, Larry A. Sklar, Tony S. Cardno, Ann R. Holmes

Publikováno v: Future Medicinal Chemistry. 8:1485-1501

Resistance to antifungal drugs is an increasingly significant clinical problem. The most common antifungal resistance encountered is efflux pump-mediated resistance of Candida species to azole drugs. One approach to overcome this resistance is to inh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6079c96ff16c2c44a2aa494a32a89687
https://doi.org/10.4155/fmc-2016-0050

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In vitroexpression ofCandida albicansalcohol dehydrogenase genes involved in acetaldehyde metabolism

Autor: Marina Mohd Bakri, Alison M. Rich, Ann R. Holmes, Richard D. Cannon

Publikováno v: Molecular Oral Microbiology. 30:27-38

Alcohol consumption is a risk factor for oral cancer, possibly via its conversion to acetaldehyde, a known carcinogen. The oral commensal yeast Candida albicans may be one of the agents responsible for this conversion intra-orally. The alcohol dehydr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2c375e16db4bdbd62ff0c5e7180591b
https://doi.org/10.1111/omi.12064

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Drug Resistance Is Conferred on the Model Yeast Saccharomyces cerevisiae by Expression of Full-Length Melanoma-Associated Human ATP-Binding Cassette Transporter ABCB5

Autor: Masakazu Niimi, Richard D. Cannon, Mikhail V. Keniya, Ann R. Holmes, Michael M. Gottesman, Erwin Lamping, Jean-Pierre Gillet

Publikováno v: Molecular Pharmaceutics

ABCB5, an ATP-binding cassette (ABC) transporter, is highly expressed in melanoma cells, and may contribute to the extreme resistance of melanomas to chemotherapy by efflux of anti-cancer drugs. Our goal was to determine whether we could functionally

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c72ee3eff62cbf4f281db0b58eafce5
https://doi.org/10.1021/mp500230b

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Adhesion of Yeast and Bacteria to Oral Surfaces

Autor: Richard D. Cannon, Kenneth Chong, Ann R. Holmes, Kyoko Niimi, Karl Lyons, Kathryn Newsham-West

Publikováno v: Methods in Molecular Biology ISBN: 9781493966837
Methods in Molecular Biology ISBN: 9781071627792

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98ea7d7d40befee96fec34f16020e7cf
https://doi.org/10.1007/978-1-4939-6685-1_10

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Multilocus sequence typing (MLST) analysis of Candida albicans isolates colonizing acrylic dentures before and after denture replacement

Autor: Khai How Choo, Ann R. Holmes, Richard D. Cannon, Hee Ji Lee, Nicholas J Knight

Publikováno v: Medical mycology. 55(6)

Yeast, in particular Candida albicans, are the principal fungal cause of denture stomatitis, and can also be present as a commensal in many individuals. Few studies, however, have examined oral retention of yeast strains over time. We analyzed the ye

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47929b6bb8e0ca25dd4f6371c799c152
https://pubmed.ncbi.nlm.nih.gov/27915298

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Denaturing gradient gel electrophoresis profiles of bacteria from the saliva of twenty four different individuals form clusters that showed no relationship to the yeasts present

Autor: Manjula Weerasekera, Richard D. Cannon, Sally A. Anderson, C.H. Sissons, Ann R. Holmes, L. Wong

Publikováno v: Archives of oral biology. 82

Objectives The aim was to investigate the relationship between groups of bacteria identified by cluster analysis of the DGGE fingerprints and the amounts and diversity of yeast present. Methods Bacterial and yeast populations in saliva samples from 2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6ce41eeb26c1aface30d6e3934a64c5
https://pubmed.ncbi.nlm.nih.gov/28577425

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The Monoamine Oxidase A Inhibitor Clorgyline Is a Broad-Spectrum Inhibitor of Fungal ABC and MFS Transporter Efflux Pump Activities Which Reverses the Azole Resistance of Candida albicans and Candida glabrata Clinical Isolates

Autor: Brian C. Monk, Mikhail V. Keniya, Richard D. Cannon, Irena Ivnitski-Steele, Larry A. Sklar, Ann R. Holmes, Erwin Lamping

Publikováno v: Antimicrobial Agents and Chemotherapy. 56:1508-1515

Resistance to the commonly used azole antifungal fluconazole (FLC) can develop due to overexpression of ATP-binding cassette (ABC) and major facilitator superfamily (MFS) plasma membrane transporters. An approach to overcoming this resistance is to i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39a91a5cc22c17da06b5ea197a1149b1
https://doi.org/10.1128/aac.05706-11

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Chimeras of Candida albicans Cdr1p and Cdr2p reveal features of pleiotropic drug resistance transporter structure and function

Autor: Masakazu Niimi, Koichi Tanabe, Minoru Nagi, Richard D. Cannon, Ann R. Holmes, Atsushi Okawada, Yoshitsugu Miyazaki, Erwin Lamping, Brian C. Monk

Publikováno v: Molecular Microbiology. 82:416-433

Members of the pleiotropic drug resistance (PDR) family of ATP binding cassette (ABC) transporters consist of two homologous halves, each containing a nucleotide binding domain (NBD) and a transmembrane domain (TMD). The PDR transporters efflux a var

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a96075c8a669ed754b6946f87d297061
https://doi.org/10.1111/j.1365-2958.2011.07820.x

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