Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Ann P. Chidgey"'
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Externí odkaz:
https://doaj.org/article/bc4220e5283f4bd288dc3172a7fccf86
Autor:
Michael Ly Hun, Kahlia Wong, Josephine Rahma Gunawan, Abdulaziz Alsharif, Kylie Quinn, Ann P. Chidgey
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
One of the main consequences of thymus aging is the decrease in naïve T cell output. This condition accelerates at the onset of puberty, and presents as a major clinical complication for cancer patients who require cytoablative therapy. Specifically
Externí odkaz:
https://doaj.org/article/4e5dfc4609ea42a1ac66f302803d275c
Autor:
Ailin Lepletier, Michael L. Hun, Maree V. Hammett, Kahlia Wong, Haroon Naeem, Mark Hedger, Kate Loveland, Ann P. Chidgey
Publikováno v:
Cell Reports, Vol 27, Iss 13, Pp 3887-3901.e4 (2019)
Summary: A key feature of immune functional impairment with age is the progressive involution of thymic tissue responsible for naive T cell production. In this study, we identify two major phases of thymic epithelial cell (TEC) loss during aging: a b
Externí odkaz:
https://doaj.org/article/78728ec7fa0b4175a39b3c1c19c61730
Autor:
Brendan J. O’Sullivan, Suman Yekollu, Roland Ruscher, Ahmed M. Mehdi, Muralidhara Rao Maradana, Ann P. Chidgey, Ranjeny Thomas
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Polymorphisms impacting thymic function may decrease peripheral tolerance and hasten autoimmune disease. The NF-κB transcription factor subunit, RelB, is essential for the development and differentiation of medullary thymic epithelial cells (mTECs):
Externí odkaz:
https://doaj.org/article/cb59225cab8e4e9d8a701100700b5698
Autor:
Danika M. Khong, Jarrod A. Dudakov, Maree V. Hammett, Marc I. Jurblum, Sacha M.L. Khong, Gabrielle L. Goldberg, Tomoo Ueno, Lisa Spyroglou, Lauren F. Young, Marcel R.M. van den Brink, Richard L. Boyd, Ann P. Chidgey
Publikováno v:
Stem Cell Reports, Vol 4, Iss 3, Pp 445-458 (2015)
Mechanisms underlying age-related defects within lymphoid-lineages remain poorly understood. We previously reported that sex steroid ablation (SSA) induced lymphoid rejuvenation and enhanced recovery from hematopoietic stem cell (HSC) transplantation
Externí odkaz:
https://doaj.org/article/f2416eba1db045e3924adadc678b2527
Autor:
Kahlia Wong, Natalie L. Lister, Marco Barsanti, Joanna M.C. Lim, Maree V. Hammett, Danika M. Khong, Christopher Siatskas, Daniel H.D. Gray, Richard L. Boyd, Ann P. Chidgey
Publikováno v:
Cell Reports, Vol 8, Iss 4, Pp 1198-1209 (2014)
Thymic epithelial cells (TECs) are critical for T cell development and self-tolerance but are gradually lost with age. The existence of thymic epithelial progenitors (TEPCs) in the postnatal thymus has been inferred, but their identity has remained e
Externí odkaz:
https://doaj.org/article/05b4b09945614dcbb028965a4d7752a3
Autor:
Chew-Li Soh, Antonietta Giudice, Robert A. Jenny, David A. Elliott, Tanya Hatzistavrou, Suzanne J. Micallef, Korosh Kianizad, Natalie Seach, Juan Carlos Zúñiga-Pflücker, Ann P. Chidgey, Alan Trounson, Susan K. Nilsson, David N. Haylock, Richard L. Boyd, Andrew G. Elefanty, Edouard G. Stanley
Publikováno v:
Stem Cell Reports, Vol 2, Iss 6, Pp 925-937 (2014)
Thymic epithelial cells (TECs) play a critical role in T cell maturation and tolerance induction. The generation of TECs from in vitro differentiation of human pluripotent stem cells (PSCs) provides a platform on which to study the mechanisms of this
Externí odkaz:
https://doaj.org/article/3c87a70547394bacac7a41d2420f7152
Publikováno v:
Clinical and Developmental Immunology, Vol 6, Iss 3-4, Pp 157-170 (1998)
Externí odkaz:
https://doaj.org/article/7a39677f211b41fba7cf2b1218bb4f32
Thymus Microenvironment: Maintenance, Ageing and Strategies for Thymus Regeneration Following Damage
Autor:
Abdulaziz Alsharif, Ann P Chidgey
Publikováno v:
eLS. :1-17
Autor:
Freya Bruveris, Jacqueline V. Schiesser, Andrew G. Elefanty, Tyrone Chen, Santhosh V. Kumar, Ali Motazedian, Elizabeth Ng, Christine A. Wells, Ann P. Chidgey, Edouard G. Stanley
Publikováno v:
Nature Cell Biology. 22:60-73
Defining the ontogeny of the human adaptive immune system during embryogenesis has implications for understanding childhood diseases including leukaemias and autoimmune conditions. Using RAG1:GFP human pluripotent stem cell reporter lines, we examine