Thin-Walled Microvessels in Human Coronary Atherosclerotic Plaques Show Incomplete Endothelial Junctions

Autor: Peter M. Frederik, Victor W.M. van Hinsbergh, Erica Pacheco, Frank D. Kolodgie, Judith C. Sluimer, Ann P Bijnens, Renu Virmani, Hans Duimel, Kimberly Maxfield, Mat J.A.P. Daemen, Bob Kutys

Publikováno v: Journal of the American College of Cardiology. 53:1517-1527

Objectives This study sought to examine the ultrastructure of microvessels in normal and atherosclerotic coronary arteries and its association with plaque phenotype. Background Microvessels in atherosclerotic plaques are an entry point for inflammato

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cbcae1ed212453b9eeafcc07010ac0c
https://doi.org/10.1016/j.jacc.2008.12.056

Prolonged shear stress and KLF2 suppress constitutive proinflammatory transcription through inhibition of ATF2

Autor: Oscar L. Volger, Mat J.A.P. Daemen, Rob J. Dekker, Jakub Rohlena, Hans Pannekoek, Joost O. Fledderus, Reinier A. Boon, Theo J.C. Van Berkel, Anton J.G. Horrevoets, Johannes V. van Thienen, Johan Kuiper, Ann P Bijnens

Publikováno v: Blood, 109(10), 4249-4257. American Society of Hematology
Fledderus, J O, Van Thienen, J V, Boon, R A, Dekker, R J, Rohlena, J, Volger, O L, Bijnens, A P J J, Daemen, M J A P, Kuiper, J, Van Berkel, T J C, Pannekoek, H & Horrevoets, A J G 2007, ' Prolonged shear stress and KLF2 suppress constitutive proinflammatory transcription through inhibition of ATF2 ', Blood, vol. 109, no. 10, pp. 4249-4257 . https://doi.org/10.1182/blood-2006-07-036020

Absence of shear stress due to disturbed blood flow at arterial bifurcations and curvatures leads to endothelial dysfunction and proinflammatory gene expression, ultimately resulting in atherogenesis. KLF2 has recently been implicated as a transcript

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::172b6282c29ed44a193a94a84676bfcd
https://research.vumc.nl/en/publications/3b604673-15b6-4873-9f8c-4c5b1c3ca1b3

Gene expression profiling of early and advanced human atherosclerotic lesions show upregulation of apoptosis related genes during lesion progression

Autor: Natasja Kisters, Susanne Baurschmidt, Ann P Bijnens, Mat J.A.P. Daemen, Veronica Herias, Kitty B.J.M. Cleutjens, Maarten D. Sollewijn Gelpke

Publikováno v: Vascular Pharmacology. 45:e47

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e0c0ef3d0e1caab0dbef51fd87b6188d
https://doi.org/10.1016/j.vph.2006.08.161