Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Ann P, Lawson"'
Autor:
Kendra A. Sirak, Daniel M. Fernandes, Mark Lipson, Swapan Mallick, Matthew Mah, Iñigo Olalde, Harald Ringbauer, Nadin Rohland, Carla S. Hadden, Éadaoin Harney, Nicole Adamski, Rebecca Bernardos, Nasreen Broomandkhoshbacht, Kimberly Callan, Matthew Ferry, Ann Marie Lawson, Megan Michel, Jonas Oppenheimer, Kristin Stewardson, Fatma Zalzala, Nick Patterson, Ron Pinhasi, Jessica C. Thompson, Dennis Van Gerven, David Reich
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Little is known about the genetic landscape of people living in the Nile region prior to the Islamic migrations of the late 1st millennium CE. Here, the authors report genome-wide data for 66 ancient individuals to investigate the genetic ancestry of
Externí odkaz:
https://doaj.org/article/7ab5d169694645f19daf803054db3508
Autor:
Nathan Nakatsuka, Pierre Luisi, Josefina M. B. Motti, Mónica Salemme, Fernando Santiago, Manuel D. D’Angelo del Campo, Rodrigo J. Vecchi, Yolanda Espinosa-Parrilla, Alfredo Prieto, Nicole Adamski, Ann Marie Lawson, Thomas K. Harper, Brendan J. Culleton, Douglas J. Kennett, Carles Lalueza-Fox, Swapan Mallick, Nadin Rohland, Ricardo A. Guichón, Graciela S. Cabana, Rodrigo Nores, David Reich
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
How Indigenous populations in the southern tip of South America have changed over time has been unclear. Here the authors generate genome-wide data for 20 ancient individuals and examine how past migrations and admixture events correlate to geography
Externí odkaz:
https://doaj.org/article/cf9a2fa320794782983aa6708a8daf40
Autor:
Lizbeth Hedstrom, Farid El Oualid, Eranthie Weerapana, Yu Qian, Rory T. Coffey, Marcus J.C. Long, Ann P. Lawson
Naturally occurring ITCs cause HMW-Ub accumulation in BaF3 cells (S1); Naturally occurring ITCs do not inhibit the proteasome (S2); Natural ITCs have few functional cysteine targets in cells (S3); Activity profiling shows PEITC and BITC inhibit USP9x
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::486df2da85da272da3e0d0c62a7dd0d9
https://doi.org/10.1158/0008-5472.22405715
https://doi.org/10.1158/0008-5472.22405715
Autor:
Lizbeth Hedstrom, Farid El Oualid, Eranthie Weerapana, Yu Qian, Rory T. Coffey, Marcus J.C. Long, Ann P. Lawson
Description of additional methods and procedures used in the study. Also includes Supplementary References.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fdcec4bb8567f4df3c15ddc87f1b698
https://doi.org/10.1158/0008-5472.22405712.v1
https://doi.org/10.1158/0008-5472.22405712.v1
Autor:
Deviprasad R. Gollapalli, Gregory D. Cuny, Adhar C. Manna, Natalia Maltseva, Barry B. Snider, Yubo Zhang, Mohana Rao Vippila, Ann P. Lawson, Lizbeth Hedstrom, Minjia Zhang, Youngchang Kim, David M Rothstein, Shibin Chacko, Petr Kuzmic, Xingyou Wang, Andrzej Joachimiak, Ryan T Cullinane, Gyan Modi, Gary M Marqus, Ambrose L. Cheung, Judy L.M. Kotler
Publikováno v:
ACS Infectious Diseases. 7:3062-3076
Many bacterial pathogens, including Staphylococcus aureus, require inosine 5'-monophosphate dehydrogenase (IMPDH) for infection, making this enzyme a promising new target for antibiotics. Although potent selective inhibitors of bacterial IMPDHs have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67a38314a14bd8ed48fa872a866f2505
https://doi.org/10.1021/acsinfecdis.1c00342
https://doi.org/10.1021/acsinfecdis.1c00342
Autor:
Seungheon Lee, Melissa S. Love, Ramkumar Modukuri, Arnab K. Chatterjee, Lauren Huerta, Ann P. Lawson, Case W. McNamara, Jan R. Mead, Lizbeth Hedstrom, Gregory D. Cuny
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 90:129328
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7dcf446f9831cd2db958c5601a963e15
https://doi.org/10.1016/j.bmcl.2023.129328
https://doi.org/10.1016/j.bmcl.2023.129328
Autor:
Gyan, Modi, Gary M, Marqus, Mohana Rao, Vippila, Deviprasad R, Gollapalli, Youngchang, Kim, Adhar C, Manna, Shibin, Chacko, Natalia, Maltseva, Xingyou, Wang, Ryan T, Cullinane, Yubo, Zhang, Judy L M, Kotler, Petr, Kuzmic, Minjia, Zhang, Ann P, Lawson, Andrzej, Joachimiak, Ambrose, Cheung, Barry B, Snider, David M, Rothstein, Gregory D, Cuny, Lizbeth, Hedstrom
Publikováno v:
ACS Infect Dis
Many bacterial pathogens, including Staphylococcus aureus, require inosine 5’-monophosphate dehydrogenase (IMPDH) for infection, making this enzyme a promising new target for antibiotics. Although potent selective inhibitors of bacterial IMPDHs hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0ad78a428808eb670c119d890ec480eb
https://pubmed.ncbi.nlm.nih.gov/34590817
https://pubmed.ncbi.nlm.nih.gov/34590817
Autor:
Lizbeth Hedstrom, Rick Baggio, Farid El Oualid, Lior Rozhansky, Marcus J. C. Long, Ann P. Lawson, Eranthie Weerapana, Yu Qian, Domenico Fasci
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:204-211
Promiscuous inhibitors of tyrosine protein kinases, proteases and phosphatases are useful reagents for probing regulatory pathways and stabilizing lysates as well as starting points for the design of more selective agents. Ubiquitination regulates ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2dc573233e39d56a711c8a1a54a6888
https://doi.org/10.1016/j.bmcl.2018.11.055
https://doi.org/10.1016/j.bmcl.2018.11.055
Autor:
Shibin Chacko, Helena I. M. Boshoff, Vinayak Singh, Davide M. Ferraris, Deviprasad R. Gollapalli, Minjia Zhang, Ann P. Lawson, Michael J. Pepi, Andrzej Joachimiak, Menico Rizzi, Valerie Mizrahi, Gregory D. Cuny, Lizbeth Hedstrom
Publikováno v:
Journal of Medicinal Chemistry. 64:18233-18234
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aca9679d608b3b2df3453a0e6410e709
https://doi.org/10.1021/acs.jmedchem.1c01923
https://doi.org/10.1021/acs.jmedchem.1c01923
Autor:
Lizbeth Hedstrom, Davide M. Ferraris, Shibin Chacko, Michael J. Pepi, Minjia Zhang, Helena I. Boshoff, Deviprasad R. Gollapalli, Vinayak Singh, Valerie Mizrahi, Gregory D. Cuny, Andrzej Joachimiak, Ann P. Lawson, Menico Rizzi
Publikováno v:
Journal of Medicinal Chemistry. 61:4739-4756
New drugs and molecular targets are urgently needed to address the emergence and spread of drug-resistant tuberculosis. Mycobacterium tuberculosis ( Mtb) inosine 5'-monophosphate dehydrogenase 2 ( MtbIMPDH2) is a promising yet controversial potential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38e74d2091981d050618d946a8dcd9ec
https://doi.org/10.1021/acs.jmedchem.7b01839
https://doi.org/10.1021/acs.jmedchem.7b01839