Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Ann O'Callaghan"'
Autor:
Christian H. Ottensmeier, Freda K. Stevenson, Gareth J. Thomas, Ugur Sahin, Petra Simon, Toni Weinschenk, Duncan I. Jodrell, Alan Anthoney, Sally Clive, Ann O'Callaghan, Andrew Bateman, Sarah Halford, Ceri Edwards, Emily Buxton, Paul Lloyd-Evans, Andrew King, Stephen M. Thirdborough, Jana Stasakova, Lindsey Chudley, Angelica Cazaly, Ann Mander, Katy J. McCann
Purpose: We have clinically evaluated a DNA fusion vaccine to target the HLA-A*0201–binding peptide CAP-1 from carcinoembryonic antigen (CEA605–613) linked to an immunostimulatory domain (DOM) from fragment C of tetanus toxin.Experimental Design:
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4202489da8884143afe28a39cda33e82
https://doi.org/10.1158/1078-0432.c.6524756.v1
https://doi.org/10.1158/1078-0432.c.6524756.v1
Low pKa of Lys promotes glycation at one complementarity-determining region of a bispecific antibody
Autor:
Xiaobin Xu, Jessica Ann O'Callaghan, Zachary Guarnero, Haibo Qiu, Ning Li, Terra Potocky, Douglas E. Kamen, Kenneth S. Graham, Mohammed Shameem, Teng-Chieh Yang
Publikováno v:
Biophysical Journal. 121:1081-1093
Autor:
Sean H. Lim, Nicola Campbell, Beth Stuart, Marina Johnson, Debora Joseph-Pietras, Adam Kelly, Danielle Jeffrey, Anna H. Turaj, Kate Rolfvondenbaumen, Celine Galloway, Thomas Wynn, Adam R. Coleman, Benjamin Ward, Karen Long, Andrew T. Bates, Diana Ayres, Robert Lown, Janlyn Falconer, Oliver Brake, James Batchelor, Victoria Willimott, Anna Bowzyk Al-Naeeb, Lisa Robinson, Ann O’Callaghan, Graham P. Collins, Tobias Menne, Saul N. Faust, Christopher P. Fox, Matthew Ahearne, Peter W.M. Johnson, Andrew J. Davies, David Goldblatt
SUMMARYSARS-CoV-2 vaccination protects against COVID-19. Antibodies and antigen-specific T-cell responses against the spike domain can be used to measure vaccine immune response. Individuals with lymphoma have defects in humoral and cellular immunity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05db81c23d3f376117b26a44fb620057
https://doi.org/10.1101/2021.12.08.21266760
https://doi.org/10.1101/2021.12.08.21266760
Autor:
Sean H. Lim, Beth Stuart, Debora Joseph-Pietras, Marina Johnson, Nicola Campbell, Adam Kelly, Danielle Jeffrey, Anna H. Turaj, Kate Rolfvondenbaumen, Celine Galloway, Thomas Wynn, Adam R. Coleman, Benjamin Ward, Karen Long, Helen Coleman, Carina Mundy, Andrew T. Bates, Diana Ayres, Robert Lown, Janlyn Falconer, Oliver Brake, James Batchelor, Victoria Willimott, Anna Bowzyk Al-Naeeb, Lisa Robinson, Ann O’Callaghan, Graham P. Collins, Tobias Menne, Saul N. Faust, Christopher P. Fox, Matthew Ahearne, Peter W. M. Johnson, Andrew J. Davies, David Goldblatt
Publikováno v:
Nature cancer. 3(5)
Patients with hematological malignancies are at increased risk of severe COVID-19 outcomes due to compromised immune responses, but the insights of these studies have been compromised due to intrinsic limitations in study design. Here we present the
Autor:
Xiaobin, Xu, Jessica Ann, O'Callaghan, Zachary, Guarnero, Haibo, Qiu, Ning, Li, Terra, Potocky, Douglas E, Kamen, Kenneth S, Graham, Mohammed, Shameem, Teng-Chieh, Yang
Publikováno v:
Biophysical journal. 121(6)
Protein glycation is a common, normally innocuous, post-translational modification in therapeutic monoclonal antibodies. However, when glycation occurs on complementarity-determining regions (CDRs) of a therapeutic monoclonal antibody, its biological
Autor:
Ann O'Callaghan, Andrew Davies, Marina Johnson, Nicola Campbell, Graham P. Collins, Peter Johnson, Sean H. Lim, Matthew J. Ahearne, David Goldblatt, Debora Joseph-Pietras, Christopher P. Fox
Publikováno v:
The Lancet. Haematology
Autor:
Marina Johnson, Ann O'Callaghan, Andrew Davies, Nicola Campbell, Graham P. Collins, Debora Joseph-Pietras, Christopher P. Fox, Peter Johnson, Matthew J. Ahearne, David Goldblatt, Sean Hua Lim
Individuals with lymphoid malignancies have an increased mortality risk from COVID-19. Paradoxically, this population is least likely to be protected by SARS-CoV-2 vaccination as a result of disease- or treatment-related immunosuppression. Current da
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00d64d2b21acd9b3c149eb1b24a2a3b1
https://doi.org/10.1101/2021.06.05.21258311
https://doi.org/10.1101/2021.06.05.21258311
Autor:
Graham P. Collins, C. Mundy, P. Johnson, B. Maynard, A. Bates, David Goldblatt, H. Coleman, Matthew J. Ahearne, S. N. Faust, R. Lown, J. Falconer, Mark H. Johnson, Debora Joseph-Pietras, V. Willimott, Ann O'Callaghan, D. Muller, N. Wetherall, N. Campbell, Andrew Davies, T. Wynn, Christopher P. Fox, Sean H. Lim
Publikováno v:
Hematological Oncology
Autor:
Vicky Goh, Alistair Rienhardt, Priya Limbu, Veronica A. Morgan, Beth Shepherd, David J. Breen, Kayleigh Gilbert, Paul Nichols, Lisa Woodrow, Neal Navani, Sophia Hans, Stephen Karp, Ruth E.C. Evans, Chris Everitt, Andrew Gogbashian, Elizabeth Chang, Nina Tunariu, Amelia Daniel, Elizabeth Hadley, Tina Mills-Baldock, Clare Collins, Ibiyemi Olaleye, Shraddha Weir, Martha Handousa, Rob Glynne-Jones, Steve Halligan, Antony Higginson, Uday Patel, Azmina Verjee, Aji Kavidasan, Sarah Howling, Andrew Bateman, Priscilla Phiri, Imogen Locke, Lyn Blakeway, Joanne Kellaway, Abel Jalloh, Elizabeth Green, Helen Pardoe, Simon Ball, Reyes Lauigan, Jonathan Wilson, Dominic Blunt, U. Ekeowa, Amy Davis, Jon Robinson, S. Burke, Prital Patel, Marian Duggan, Harbir S. Sidhu, Farzana Rahman, Sofia Gourtsoyianni, Shaki Balogun, Pippa Riddle, Peter Boavida, Colin Elton, Stefania Stegner, Daniel J. Smith, Zoltan Nagy, Suzanne Chukundah, Jenna Couture, Laura L. Quinn, Terry O'Shaughnessy, Revanth Jannapureddy, Heather Hughes, Shonit Punwani, Subramanian Ramesh, Anne Miles, Sajid A. Khan, Michelle Saull, Stuart A. Taylor, Tanjil Nawaz, Khawaja Shahabuddin, Andy Lowe, Gauraang Bhatnagar, James Crosbie, Thida Win, Rashidat Adeniba, Helen Beedham, Sahar Naaseri, Nicola Lucas, Fiona McKirdy, Abby Sharp, Lorraine Hurl, Nicola Gibbons, Laura Hughes, Alison Morton, William Partridge, Amy Smith, Krystyna Reczko, Rudi Borgstein, Ann O'Callaghan, Davide Prezzi, Ayshea Hameeduddin, Nelesh Jeyadevan, Matthew Train, John O'Donohue, Teresa Light, Shahanara Ferdous, Austen Obichere, Caroline S. Clarke, Wivijin Piga, Anita Rhodes, Ian C Simcock, Meena Reddi, Shanna Wilson, John Bridgewater, Keyury Desai, Anwar R. Padhani, Maureen Furneaux, Raj Srirajaskanthan, Kishor Barhate, Anita Amadi, Sandy Beare, Dorothee Boisfer, Ferrial Syeed, Elizabeth Isaac, Amjad Mohammed, Katie Prior, Mohamed A. Thaha, Jonathan McCullogh, Kara Sargus, Andrea Rockall, Clive Kay, David Chao, Eleni Ntala, J. James Stirling, Dow-Mu Koh, David Birch, Adrian Green, Marie Jackson, Sanjaya Wijeyekoon, Girija Anand, Hameed Rafiee, Ali Mohammed, Richard Beable, William Ricketts, Liane Davis, Shafi Ahmed, Tina Stoycheva, Sally O'Connor, Jamila Roehrig, Steve Ellis, Catherine Norman, Balinder Hans, Nishat Bharwani, Peter Russell, Kitrick Perry, Ellice Marwood, Alfred Oliver, Stephen Morris, Veronica Conteh, Eleni Karapanagiotou, Saba Mahmud, Sidra Tulmuntaha, Christian Kelly-Morland, Alice Johnson, Sasithar Maheswaran, Farid Bazari, Yvonne Campbell, Rajapandian Ilangovan, Adnam Alam, Tuck-Kay Loke, Susan Mallett, G. Atkin, Nicola H. Strickland, Dominic Yu, Ashley M. Groves, Chloe van Someren, Ian Jenkins, Kai-Keen Shiu, Colm Prendergast, Sherif Raouf, Jagadish Kalasthry, David Snell, Nathalie Rich, Louise Lim, Michael Long, Edward W. Johnston, Kathryn Tarver, Sam M. Janes, Laletha Agoramoorthy, Rommel Butawan, Pooja Datt, Jonathan Teague, Christopher Wanstall, Jane De Los, Sara Lock, Adoracion Jayme, Alec Engledow, Janet McGowan, Andre Nunes, Akosa Aboagye, Howard Curtis, Teresita Beeston, Angshu Bhowmik, Gule Hanid, E. Scurr, Payal Julka, Lesley Honeyfield, Aileen Austria, Celia Simeon, Katherine van Ree, Adesewa Onajobi, Lara Curry
Publikováno v:
2019, ' Diagnostic accuracy of whole-body MRI versus standard imaging pathways for metastatic disease in newly diagnosed colorectal cancer : the prospective Streamline C trial ', The Lancet Gastroenterology & Hepatology, vol. 4, no. 7, pp. 529-537 . https://doi.org/10.1016/S2468-1253(19)30056-1
The Lancet. Gastroenterology & Hepatology
The Lancet. Gastroenterology & Hepatology
BACKGROUND: Whole-body MRI (WB-MRI) could be an alternative to multimodality staging of colorectal cancer, but its diagnostic accuracy, effect on staging times, number of tests needed, cost, and effect on treatment decisions are unknown. We aimed to
Publikováno v:
Rheumatology. 59
Background A 73 year old man was diagnosed with diffuse large B-cell lymphoma germinal centre phenotype, after presenting with a 86x70x45mm right anterior chest wall lesion. CT CAP showed no further lymphadenopathy but identified an additional solid