Growth Hormone and Obesity

Autor: Steen B. Pedersen, Morten Hogild, Niels Møller, Niels Jessen, Bjørn Richelsen, Ann Mosegaard Bak, Astrid Johannesson Hjelholt, Amanda Bæk, Mai Christiansen Arlien-Søborg, Jens Otto Lunde Jørgensen

Publikováno v: Hjelholt, A, Høgild, M, Bak, A M, Arlien-Søborg, M C, Bæk, A, Jessen, N, Richelsen, B, Pedersen, S B, Møller, N & Lunde Jørgensen, J O 2020, ' Growth Hormone and Obesity ', Endocrinology and Metabolism Clinics of North America, vol. 49, no. 2, pp. 239-250 . https://doi.org/10.1016/j.ecl.2020.02.009

Growth hormone (GH) exerts IGF-I dependent protein anabolic and direct lipolytic effects. Obesity reversibly suppresses GH secretion driven by elevated FFA levels, whereas serum IGF-I levels remain normal or elevated due to elevated portal insulin le

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https://pure.au.dk/portal/da/publications/growth-hormone-and-obesity(eb3746bd-be4a-42c0-9bca-638f7635c0a9).html

Prolonged fasting-induced metabolic signatures in human skeletal muscle of lean and obese men

Autor: Niels Møller, Jens Otto Lunde Jørgensen, Britt Christensen, Ann Mosegaard Bak, Mikkel H. Vendelbo, Niels Jessen, Bo Martin Bibby, Rikke Viggers, Jørgen Rungby

Publikováno v: PLoS ONE, Vol 13, Iss 9, p e0200817 (2018)
Bak, A M, Vendelbo, M H, Christensen, B, Viggers, R, Bibby, B M, Rungby, J, Jørgensen, J O L, Møller, N & Jessen, N 2018, ' Prolonged fasting-induced metabolic signatures in human skeletal muscle of lean and obese men ', PLOS ONE, vol. 13, no. 9, e0200817 . https://doi.org/10.1371/journal.pone.0200817

Insulin resistance is a well-known physiological adaptation to prolonged fasting in healthy skeletal muscle. Obesity is associated with insulin resistance and metabolic inflexibility in skeletal muscle, and a pronounced increase in the risk of metabo

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https://pubmed.ncbi.nlm.nih.gov/30183740

Differential regulation of lipid and protein metabolism in obese vs. lean subjects before and after a 72-h fast

Autor: Thomas Nielsen, Steen B. Pedersen, Jens Otto Lunde Jørgensen, Niels Møller, Jørgen Rungby, Niels Jessen, Ann Mosegaard Bak, Rikke Viggers, Andreas Buch Møller, Mikkel H. Vendelbo

Publikováno v: Bak, A M, Møller, A B, Vendelbo, M H, Nielsen, T S, Viggers, R, Rungby, J, Pedersen, S B, Jørgensen, J O L, Jessen, N & Møller, N 2016, ' Differential regulation of lipid and protein metabolism in obese vs. lean subjects before and after a 72-h fast ', American Journal of Physiology: Endocrinology and Metabolism, vol. 311, no. 1, pp. E224-35 . https://doi.org/10.1152/ajpendo.00464.2015

Increased availability of lipids may conserve muscle protein during catabolic stress. Our study was designed to define 1) intracellular mechanisms leading to increased lipolysis and 2) whether this scenario is associated with decreased amino acid and

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https://pure.au.dk/portal/da/publications/differential-regulation-of-lipid-and-protein-metabolism-in-obese-vs-lean-subjects-before-and-after-a-72h-fast(8469fecb-fac5-4c00-a57a-dd63502edc4d).html

Epidemiology of Cushing’s Syndrome

Autor: Jens Otto Lunde Jørgensen, Kristine Zøylner Rubeck, Ann Mosegaard Bak, Charlotte Steffensen

Publikováno v: Steffensen, C, Bak, A M, Rubeck, K Z & Jørgensen, J O L 2010, ' Epidemiology of Cushing's syndrome ', Neuroendocrinology, vol. 92 Suppl 1, pp. 1-5 . https://doi.org/10.1159/000314297

Udgivelsesdato: 2010-null Overt Cushing's syndrome is a rare disorder with an annual incidence of 2-3/million of which benign adrenal adenomas account for 0.6/million. The female:male ratio is 3:1. Preliminary data indicate a high proportion of subcl

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https://doi.org/10.1159/000314297

Growth hormone-induced insulin resistance in human subjects involves reduced pyruvate dehydrogenase activity

Autor: Niels Jessen, Ann Mosegaard Bak, Jens Otto Lunde Jørgensen, Henriette Pilegaard, Mikkel H. Vendelbo, Birgitte Nellemann, Morten Hogild, Rasmus S. Biensø, Thomas Nielsen, Niels Møller, Steen B. Pedersen

Publikováno v: Nellemann, B, Vendelbo, M H, Nielsen, T S, Bak, A M, Høgild, M, Pedersen, S B, Biensø, R S, Pilegaard, H, Møller, N, Jessen, N & Jørgensen, J O L 2014, ' Growth hormone-induced insulin resistance in human subjects involves reduced pyruvate dehydrogenase activity ', Acta Physiologica
, vol. 210, no. 2, pp. 392-402 . https://doi.org/10.1111/apha.12183

Insulin resistance induced by growth hormone (GH) is linked to promotion of lipolysis by unknown mechanisms. We hypothesized that suppression of the activity of pyruvate dehydrogenase in the active form (PDHa) underlies GH-induced insulin resistance

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https://pure.au.dk/portal/da/publications/growth-hormoneinduced-insulin-resistance-in-human-subjects-involves-reduced-pyruvate-dehydrogenase-activity(0680f31a-f042-4a2c-8f14-556d042636e9).html