Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Ann Maslen"'
Autor:
Meghan Larin, Lorraine Ng, Ann Maslen, Kathleen D. Nichols, Patrick Maurel, Jean-Marc Pascussi, Tania Onica, M.J. Vilarem, Zdenek Dvorak, Gordon M. Kirby
Publikováno v:
Molecular Pharmacology. 73:451-460
Human cytochrome P450 2A6 (CYP2A6) metabolizes various clinically relevant compounds, including nicotine- and tobacco-specific procarcinogens; however, transcriptional regulation of this gene is poorly understood. We investigated the role of the gluc
Publikováno v:
Biochemical Journal. 400:135-141
The effect of GSTA1-1 (glutathione S-transferase Alpha 1-1) on JNK (c-Jun N-terminal kinase) activation was investigated in Caco-2 cells in which GSTA1 expression increases with degree of confluency, and in MEF3T3 cells with Tet-Off-inducible GSTA1 e
Publikováno v:
Molecular Pharmacology. 71:201-208
Down-regulation of glutathione transferase A1 (GSTA1) expression has profound implications in cytoprotection against toxic by-products of lipid peroxidation produced during inflammation. We investigated the role of hepatic nuclear factor 1 (HNF-1) in
Autor:
Marnie A. Higgins, Heather J. Barker, Ann Maslen, James Gilmore, Kim Boudreau, Gordon M. Kirby, Laura Romero
Publikováno v:
Drug Metabolism and Disposition. 30:1186-1193
The influence of pro-inflammatory cytokines on alpha class glutathione S-transferase A1 and A2 (GSTA1/A2) expression was examined in human colonic epithelial cells (Caco-2) in culture. Dose-dependent reductions in GSTA1/A2 mRNA, protein, and activity
Publikováno v:
Cancer Letters. 177:65-74
Glutathione S-transferase (GST) mu phenotype was assessed in colon tissue from patients with ulcerative colitis and colorectal neoplasms that were positive for GSTM1 genotype. GST mu protein (enzyme linked immunosorbent assay) was absent in 2/9 unaff
Autor:
Laura, Romero, A, Higgins Marnie, James, Gilmore, Kim, Boudreau, Ann, Maslen, J, Barker Heather, M, Kirby Gordon
Publikováno v:
Drug Metabolism and Disposition; November 2002, Vol. 30 Issue: 11 p1186-93, 8p