Výsledky vyhledávání - "Ann Mary, Joseph"

Akademický článek

Revisiting surfactant protein D: an immune surveillance molecule bridging innate and adaptive immunity

Autor: Azra Shamim, Mughair Abdul Aziz, Faryal Saeed, Rekha Kumari, Ann Mary Joseph, Pretty Ponnachan, Uday Kishore, Khaled Masmoudi

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

Surfactant protein D (SP-D) is a C-type lectin that was originally discovered as a lung surfactant associated phospholipid recognising protein. It was originally shown to be of great importance in surfactant turnover and homeostasis in conjunction wi

Externí odkaz: https://doaj.org/article/c1ca0cf8a93a4562a531e6dcb3162b1d

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Akademický článek

Innate and adaptive immune-directed tumour microenvironment in pancreatic ductal adenocarcinoma

Autor: Ann Mary Joseph, Ahmad Al Aiyan, Basel Al-Ramadi, Shiv K. Singh, Uday Kishore

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

One of the most deadly and aggressive cancers in the world, pancreatic ductal adenocarcinoma (PDAC), typically manifests at an advanced stage. PDAC is becoming more common, and by the year 2030, it is expected to overtake lung cancer as the second gr

Externí odkaz: https://doaj.org/article/bb64a3116b7f44199801904723b0f8bc

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Data from Cross-talk between 4-1BB and TLR1–TLR2 Signaling in CD8+ T Cells Regulates TLR2′s Costimulatory Effects

Autor: Eduardo Davila, Jovanny Zabaleta, Ratika Srivastava, Ann Mary Joseph

The activation of TLR-MyD88 (Toll-like receptor-myeloid differentiation factor 88) signaling within T cells functions as a potent costimulatory signal that boosts antitumor and antiviral responses. However, the molecular mechanisms underlying the cos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b64e2afa8bb67df32ff1fca664fef1c7
https://doi.org/10.1158/2326-6066.c.6548659.v1

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Data from A Synthetic CD8α:MyD88 Coreceptor Enhances CD8+ T-cell Responses to Weakly Immunogenic and Lowly Expressed Tumor Antigens

Autor: Eduardo Davila, Cruz Velasco Gonzales, Yuji Zhang, Kenisha Younger, Jackline Joy Lasola, Alexander K Tsai, Jitao Guo, Ann Mary Joseph, Sabina Kaczanowska

T cell–based immunotherapies are a promising approach for patients with advanced cancers. However, various obstacles limit T-cell efficacy, including suboptimal T-cell receptor (TCR) activation and an immunosuppressive tumor environment. Here, we d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::193ea8dedfc00e4647b1dd8edb28aebc
https://doi.org/10.1158/0008-5472.c.6509513

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