Zobrazeno 1 - 10
of 208
pro vyhledávání: '"Ann Marshak‐Rothstein"'
Autor:
Kevin MingJie Gao, Kristy Chiang, Zhaozhao Jiang, Filiz T. Korkmaz, Harish P. Janardhan, Chinmay M. Trivedi, Lee J. Quinton, Sebastien Gingras, Katherine A. Fitzgerald, Ann Marshak-Rothstein
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 114114- (2024)
Summary: Patients afflicted with Stimulator of interferon gene (STING) gain-of-function mutations frequently present with debilitating interstitial lung disease (ILD) that is recapitulated in mice expressing the STINGV154M mutation (VM). Prior radiat
Externí odkaz:
https://doaj.org/article/2a4efdec376a4801b850043d6a406d50
Autor:
Nazgol-Sadat Haddadi, Purvi Mande, Tia Y. Brodeur, Kaiyuan Hao, Grace E. Ryan, Stephanie Moses, Sharon Subramanian, Xhuliana Picari, Khashayar Afshari, Ann Marshak-Rothstein, Jillian M. Richmond
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Cutaneous lupus erythematosus (CLE) is an autoimmune skin disease characterized by a strong IFN signature, normally associated with type I IFNs. However, increasing evidence points to an additional role for IFNγ, or at least a pathogenic T effector
Externí odkaz:
https://doaj.org/article/32f5e6333f6d49e8a5ab52fd9cd4b573
Autor:
Kevin M. Gao, Alan G. Derr, Zhiru Guo, Kerstin Nündel, Ann Marshak-Rothstein, Robert W. Finberg, Jennifer P. Wang
Publikováno v:
JCI Insight, Vol 6, Iss 22 (2021)
BACKGROUND Influenza A virus (IAV) and SARS-CoV-2 are pandemic viruses causing millions of deaths, yet their clinical manifestations are distinctly different.METHODS With the hypothesis that upper airway immune and epithelial cell responses are also
Externí odkaz:
https://doaj.org/article/2ff7048d069a471986b8930eede14d4a
Autor:
Anitha Krishnan, Andrew J. Kocab, David N. Zacks, Ann Marshak-Rothstein, Meredith Gregory-Ksander
Publikováno v:
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-15 (2019)
Abstract Background Glaucoma is a complex, multifactorial disease where apoptosis, microglia activation, and inflammation have been linked to the death of retinal ganglion cells (RGCs) and axon degeneration. We demonstrated previously that FasL-Fas s
Externí odkaz:
https://doaj.org/article/414b24d38f60448292315ecd971e04c6
Autor:
Mona Motwani, Jason McGowan, Jennifer Antonovitch, Kevin MingJie Gao, Zhaozhao Jiang, Shruti Sharma, Gretchen A. Baltus, Kevin M. Nickerson, Ann Marshak-Rothstein, Katherine A. Fitzgerald
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Detection of DNA is an important determinant of host-defense but also a driver of autoinflammatory and autoimmune diseases. Failure to degrade self-DNA in DNAseII or III(TREX1)-deficient mice results in activation of the cGAS-STING pathway. Deficienc
Externí odkaz:
https://doaj.org/article/fa75b31b38f0482698b841d9e116acff
Autor:
Meredith S Gregory, Caroline G Hackett, Emma F Abernathy, Karen S Lee, Rebecca R Saff, Andreas M Hohlbaum, Krishna-Sulayman L Moody, Maura W Hobson, Alexander Jones, Paraskevi Kolovou, Saoussen Karray, Andrea Giani, Simon W M John, Dong Feng Chen, Ann Marshak-Rothstein, Bruce R Ksander
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17659 (2011)
Glaucoma, the most frequent optic neuropathy, is a leading cause of blindness worldwide. Death of retinal ganglion cells (RGCs) occurs in all forms of glaucoma and accounts for the loss of vision, however the molecular mechanisms that cause RGC loss
Externí odkaz:
https://doaj.org/article/9f8fa3749ccc4379a58e97546f95ec8d
Autor:
Fiona Raso, Shuozhi Liu, Mikala JoAnn Willett, Gregory Barton, Christian Thomas Mayer, Oliver Bannard, Mridu Acharya, Jagan R. Muppidi, Ann Marshak-Rothstein, Andrea Reboldi
Immunoglobulin A (IgA), the main antibody isotype found in the intestine, has evolved to maintain the stability of commensal communities, and prevent dysbiosis. In stark contrast to systemic antibody response against pathogens, the generation of IgA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1321a6284d5217c6758faadcdb3ed64
https://doi.org/10.1101/2023.03.16.532481
https://doi.org/10.1101/2023.03.16.532481
Autor:
Olivia Kugler‐Umana, Wenliang Zhang, Yi Kuang, Jialing Liang, Catherine H. Castonguay, Susan L. Tonkonogy, Ann Marshak‐Rothstein, Priyadharshini Devarajan, Susan L. Swain
Publikováno v:
Aging Cell. 21
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36b135c25a10546e7c76e0accc6293c3
https://doi.org/10.1111/acel.13705
https://doi.org/10.1111/acel.13705
Autor:
Olivia, Kugler-Umana, Wenliang, Zhang, Yi, Kuang, Jialing, Liang, Catherine H, Castonguay, Susan L, Tonkonogy, Ann, Marshak-Rothstein, Priyadharshini, Devarajan, Susan L, Swain
Publikováno v:
Aging cell. 21(10)
Age-associated B cells (ABC) accumulate with age and are associated with autoimmunity and chronic infection. However, their contributions to acute infection in the aged and their developmental pathways are unclear. We find that the response against i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::210c91a430dd4fda1c6783385a5284df
https://pubmed.ncbi.nlm.nih.gov/36056604
https://pubmed.ncbi.nlm.nih.gov/36056604
Autor:
Kevin MingJie Gao, Mona Motwani, Thomas Tedder, Ann Marshak-Rothstein, Katherine A. Fitzgerald
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Pediatric patients with constitutively active mutations in the cytosolic double-stranded-DNA-sensing adaptor STING develop an autoinflammatory syndrome known as STING-associated vasculopathy with onset in infancy (SAVI). SAVI patients have elevated i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fa964145efc4635ab5be93b660e3cbe
https://doi.org/10.1073/pnas.2202327119
https://doi.org/10.1073/pnas.2202327119