Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Ann Marie L. Ogden"'
Autor:
Kirk W. Johnson, Baolin Li, Ann Marie L. Ogden, David Bleakman, Yuewei Qian, Elizabeth Rex, He Wang
Publikováno v:
ASSAY and Drug Development Technologies. 14:131-143
The association between the kainate receptors (KARs) GluK1 and GluK2 and the modifying proteins neuropilin- and tolloid-like 1 (NETO1), neuropilin- and tolloid-like 2 (NETO2), and postsynaptic density protein 95 (PSD95) is likely to produce distinct
Autor:
Brian M. Arnold, Miriam del Prado, Smriti Iyengar, Edward L. Mattiuz, Zhipei Wu, Mark A. Winter, David Bleakman, Ken H. Ho, Ann Marie L. Ogden, Paul L. Ornstein, Carrie K. Jones, Sandra Ann Filla, Brian Michael Mathes, Michael Gregory Bell, Douglas Richard Stack, Ana Maria Escribano, Thomas J. Bleisch, Ana I. Mateo, Kevin John Hudziak, Andrew Alt, Rosa Maria A. Simmons, Harlan E. Shannon, Robert E. Stratford, Jose A. Martinez-Perez, Esteban Dominguez, Ana M. Castaño
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:6459-6462
The synthesis and structure-activity relationship of decahydroisoquinoline derivatives with various benzoic acid substitutions as GluK1 antagonists are described. Potent and selective antagonists were selected for a tailored prodrug approach in order
Autor:
Gary Gilmour, Ann Marie L. Ogden, Sally Loomis, Anthony J. Baucum, Teri L. Belecky-Adams, Jonathan M. Wilson, Kalpana M. Merchant
Publikováno v:
Neuropharmacology. 99
Studies described here tested the hypothesis that phosphodiesterase 10A inhibition by a selective antagonist, MP-10, activates the dopamine D2 receptor expressing medium spiny neurons to a greater extent than the D1 receptor expressing neurons. We us
Autor:
Edward L. Mattiuz, Ann Marie L. Ogden, Ana M. Castaño, Zhipei Wu, Robert E. Stratford, E. Dominguez, Thomas J. Bleisch, Brian Michael Mathes, Brian M. Arnold, David Bleakman, Smriti Iyengar, Rosa Maria A. Simmons, Harlan E. Shannon, Sandra Ann Filla, Jose A. Martinez-Perez, Douglas Richard Stack, Ana I. Mateo, Miriam del Prado, Kevin John Hudziak, Andrew Alt, Michael Gregory Bell, Carrie K. Jones, Paul L. Ornstein, Jennifer L. Buckmaster, Ana Maria Escribano, Mark A. Winter, Ken H. Ho
Publikováno v:
Journal of Medicinal Chemistry. 48:4200-4203
Amino acids 5 and 7, two potent and selective competitive GluR5 KA receptor antagonists, exhibited high GluR5 receptor affinity over other glutamate receptors. Their ester prodrugs 6 and 8 were orally active in three models of pain: reversal of forma
Autor:
Mary Gates, Michael J. O'Neill, Katherine Whalley, David Bleakman, David M. Lodge, Jim Vandergriff, Dennis M. Zimmerman, Phil Skolnick, Mark A Ward, Tracey K. Murray, Eric S. Nisenbaum, Edward R. Siuda, Polly Baumbarger, Caroline A Hicks, Christine S. Robinson, Ann Marie L. Ogden
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 306:752-762
Glutamate is the major excitatory transmitter in the brain. Recent developments in the molecular biology and pharmacology of the α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) subtype of glutamate receptors have led to the discovery of
Autor:
Ken H. Ho, Edward L. Mattiuz, Ann Marie L. Ogden, Brian Michael Mathes, Ana I. Mateo, David Bleakman, Kevin John Hudziak, Donna K. Dieckman, Sandra Ann Filla, Mark A. Winter, Thomas J. Bleisch, Ana Maria Escribano, Paul L. Ornstein, Kirk W. Johnson, Douglas Richard Stack, Amy Clemens-Smith, Miriam del Prado, Ana M. Castaño, Mary A. Katofiasc, Robert E. Stratford, E. Dominguez, Michael Gregory Bell, Lee A. Phebus, Jose A. Martinez-Perez
Publikováno v:
Journal of Medicinal Chemistry. 45:4383-4386
Amino diacid 3, a highly selective competitive GluR5 kainate receptor antagonist, exhibited high GluR5 receptor affinity and selectivity over other glutamate receptors. Its diethyl ester prodrug 4 was orally active in two models of migraine: the neur
Autor:
Miriam del Prado, Ken H. Ho, Brian Michael Mathes, Smriti Iyengar, Mark A. Winter, Harlan E. Shannon, Carrie K. Jones, David K. Clawson, Ana Maria Escribano, Douglas Richard Stack, Esteban Dominguez, Paul L. Ornstein, Ana I. Mateo, Jose A. Martinez-Perez, Kevin John Hudziak, Andrew Alt, Edward L. Mattiuz, Brian M. Arnold, Sandra Ann Filla, Thomas J. Bleisch, Ana M. Castaño, Michael Gregory Bell, Rosa Maria A. Simmons, Robert E. Stratford, Ann Marie L. Ogden, Zhipei Wu, David Bleakman
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(23)
We have explored the decahydroisoquinoline scaffold, bearing a phenyl tetrazole, as GluK1 antagonists with potential as oral analgesics. We have established the optimal linker atom between decahydroisoquinoline and phenyl rings and demonstrated an im
Autor:
Norton P. Peet, Ann Marie L. Ogden, David A. Demeter, Herschel J. R. Weintraub, Elaine C. Meng, Mark W. Dudley, Nelsen L. Lentz, Philippe Bey
Publikováno v:
ChemInform. 22
Le nouveau mode de liaison propose est corrobore par des comparaisons de charges atomiques partielles, par une modelisation moleculaire, et une nouvelle synthese des xanthines, permettant l'introduction d'une unite de reconnaisance chirale en positio
Autor:
M. A. Staeger, Yaw Senyah, Miller Francis P, Timothy C. McCloskey, Ann Marie L. Ogden, Herbert J. Ketteler, John M. Kane, John H. Kehne, Dalton Christopher R, P. A. Chmielewski, Mark W. Dudley, Jerry A. Miller
Publikováno v:
ChemInform. 25
Publikováno v:
Journal of Medicinal Chemistry. 35:3263-3269
Two modes of tethering a chiral (phenylisopropyl)amino substituent in pyrazolo[3,4-d]pyrimidines and purines have been explored. One mode gave (S)-2,7-dihydro-7-phenyl-2-(phenylmethyl)-5- propoxy-3H-imidazo[1,2-c]pyrazolo-[4,3-e]pyrimidine (12a) and