Zobrazeno 1 - 10
of 134
pro vyhledávání: '"Ann M. Stock"'
Publikováno v:
mBio, Vol 15, Iss 7 (2024)
ABSTRACT Hybrid two-component systems (HTCSs) comprise a major class of transcription regulators of polysaccharide utilization genes in Bacteroides. Distinct from classical two-component systems in which signal transduction is carried out by intermol
Externí odkaz:
https://doaj.org/article/7ca82a07cc3e480ba273a6a88367ec61
Autor:
Nicolas Papon, Ann M. Stock
Publikováno v:
F1000Research, Vol 8 (2019)
Signal transduction systems configured around a core phosphotransfer step between a histidine kinase and a cognate response regulator protein occur in organisms from all domains of life. These systems, termed two-component systems, constitute the maj
Externí odkaz:
https://doaj.org/article/6da4c8925f2c478db64e24ef56944d71
Autor:
Samar Kabbara, Baptiste Bidon, Jaafar Kilani, Marwan Osman, Monzer Hamze, Ann M. Stock, Nicolas Papon
Publikováno v:
Biomolecules, Vol 10, Iss 2, p 186 (2020)
Although it has long been known that bacteria detect and react to plant chemicals to establish an interaction, the cellular signaling mechanisms involved in these perception processes have hitherto remained obscure. Some exciting recent advances in t
Externí odkaz:
https://doaj.org/article/a2d82d8be60c4907af729cbc87091a89
Autor:
Rong Gao, Ann M. Stock
Publikováno v:
Cell Reports, Vol 24, Iss 11, Pp 3061-3071.e6 (2018)
Summary: A fundamental trade-off between rapid response and optimal expression of genes below cytotoxic levels exists for many signaling circuits, particularly for positively autoregulated systems with an inherent response delay. Here, we describe a
Externí odkaz:
https://doaj.org/article/215782e6cca24505b4ed21622d0ee99d
Autor:
Rong Gao, Ann M. Stock
Publikováno v:
mBio, Vol 8, Iss 3 (2017)
ABSTRACT Cells rely on accurate control of signaling systems to adapt to environmental perturbations. System deactivation upon stimulus removal is as important as activation of signaling pathways. The two-component system (TCS) is one of the major ba
Externí odkaz:
https://doaj.org/article/fdd73206e3674653b99c87c55f9184d1
Autor:
Rong Gao, Ann M. Stock
Publikováno v:
mBio, Vol 6, Iss 3 (2015)
ABSTRACT Understanding cellular responses to environmental stimuli requires not only the knowledge of specific regulatory components but also the quantitative characterization of the magnitude and timing of regulatory events. The two-component system
Externí odkaz:
https://doaj.org/article/e199c81435704fd9b26799e252aaa680
Autor:
Rong Gao, Samantha E. Brokaw, Zeyue Li, Libby J. Helfant, Ti Wu, Muhammad Malik, Ann M. Stock
Publikováno v:
PLoS computational biology. 18(11)
Binding of transcription factor (TF) proteins to regulatory DNA sites is key to accurate control of gene expression in response to environmental stimuli. Theoretical modeling of transcription regulation is often focused on a limited set of genes of i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ba45cd63ff3e71dce207bb170bca4f3
https://pubmed.ncbi.nlm.nih.gov/36413575
https://pubmed.ncbi.nlm.nih.gov/36413575
Publikováno v:
J Biol Chem
Histidine protein kinases (HKs) are prevalent prokaryotic sensor kinases that are central to phosphotransfer in two-component signal transduction systems, regulating phosphorylation of response regulator proteins that determine the output responses.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b1f409ec708c3cddf3cb3515d58a8b6
https://doi.org/10.1074/jbc.ra120.012757
https://doi.org/10.1074/jbc.ra120.012757
Publikováno v:
Nucleic Acids Research
Studies of transcription regulation are often focused on binding of transcription factors (TFs) to a small number of promoters of interest. It is often assumed that TFs are in great excess to their binding sites (TFBSs) and competition for TFs betwee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::483c5da5110dbdc45427f7e638c6f4d6
https://pubmed.ncbi.nlm.nih.gov/34669947
https://pubmed.ncbi.nlm.nih.gov/34669947
Publikováno v:
Annual Review of Microbiology. 73:175-197
Response regulators function as the output components of two-component systems, which couple the sensing of environmental stimuli to adaptive responses. Response regulators typically contain conserved receiver (REC) domains that function as phosphory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37ac5ca90b3f77c9313147f12392b355
https://doi.org/10.1146/annurev-micro-020518-115931
https://doi.org/10.1146/annurev-micro-020518-115931