Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Ann M. Sherry"'
Autor:
Ann M. Sherry, Myra L. Patchen, John Cuppoletti, Kirti P. Tewari, Qiu-ju Li, Ryuji Ueno, Danuta H. Malinowska
Publikováno v:
American Journal of Physiology-Cell Physiology. 287:C1173-C1183
The purpose of this study was to determine the mechanism of action of SPI-0211 (lubiprostone), a novel bicyclic fatty acid in development for the treatment of bowel dysfunction. Adult rabbit intestine was shown to contain mRNA for ClC-2 using RT-PCR,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4174d0fd5d26ce3d27a2436d6889a890
https://doi.org/10.1152/ajpcell.00528.2003
https://doi.org/10.1152/ajpcell.00528.2003
Publikováno v:
American Journal of Physiology-Cell Physiology. 286:C495-C506
Our objective was to identify and localize a K+channel involved in gastric HCl secretion at the parietal cell secretory membrane and to characterize and compare the functional properties of native and recombinant gastric K+channels. RT-PCR showed tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a143033a0712be3b739df74f35c400e0
https://doi.org/10.1152/ajpcell.00386.2003
https://doi.org/10.1152/ajpcell.00386.2003
Publikováno v:
American Journal of Physiology-Cell Physiology. 281:C46-C54
ClC-2 Cl− channels represent a potential target for therapy in cystic fibrosis. Key questions regarding the feasibility of using ClC-2 as a therapeutic target are addressed in the present studies, including whether the channels are present in human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d6ec4fe270012e4d3b86ad0443631ff
https://doi.org/10.1152/ajpcell.2001.281.1.c46
https://doi.org/10.1152/ajpcell.2001.281.1.c46
Publikováno v:
Clinical and Experimental Pharmacology and Physiology. 27:896-900
1. The CIC-2 Cl- channels are present in the adult human lung epithelia and, therefore, are a potential target for therapy in cystic fibrosis. 2. Activators of CIC-2 Cl- channels that may have physiological relevance include activation by reduced ext
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33f9f663890fc70100137e89025a88fc
https://doi.org/10.1046/j.1440-1681.2000.03357.x
https://doi.org/10.1046/j.1440-1681.2000.03357.x
Publikováno v:
Mechanisms and Consequences of Proton Transport ISBN: 9781461353300
The purpose of this article is to review the literature regarding the characteristics of the gastric parietal cell apical membrane K+ channel and provide new evidence that suggests that the inward rectifying K+ channel, Kir2.1, may be involved in K+
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb8b79dae7bb95a4d9fc72a159068446
https://doi.org/10.1007/978-1-4615-0971-4_29
https://doi.org/10.1007/978-1-4615-0971-4_29
Publikováno v:
Mechanisms and Consequences of Proton Transport ISBN: 9781461353300
The Cl-channel of the apical membrane of the gastric parietal cell was characterized in native rabbit H/K ATPase-containing membrane vesicles in bilayer reconstitution studies. It is a linear Cl- channel which exhibits activation by reduction of extr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1375345fa14b9744ac33ec7c667c6881
https://doi.org/10.1007/978-1-4615-0971-4_27
https://doi.org/10.1007/978-1-4615-0971-4_27
Autor:
Randal E. Morris, Danuta H. Malinowska, John Cuppoletti, Georgianne M. Ciraolo, Ann M. Sherry
Publikováno v:
American journal of physiology. Cell physiology. 280(6)
HCl secretion across the parietal cell apical secretory membrane involves the H+-K+-ATPase, the ClC-2 Cl−channel, and a K+channel. In the present study, the cellular and subcellular distribution of ClC-2 mRNA and protein was determined in the rabbi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::038f5d51526dfc79b2ba65f9ce874fe3
https://pubmed.ncbi.nlm.nih.gov/11350755
https://pubmed.ncbi.nlm.nih.gov/11350755
Publikováno v:
American journal of physiology. Cell physiology. 279(1)
An HEK-293 cell line stably expressing the human recombinant ClC-2 Cl−channel was used in patch-clamp studies to study its regulation. The relative permeability Px/ PClcalculated from reversal potentials was I−> Cl−= NO3−= SCN−≥Br−. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c421427bd875d002395b112a6c45461e
https://pubmed.ncbi.nlm.nih.gov/10898715
https://pubmed.ncbi.nlm.nih.gov/10898715
Autor:
John Cuppoletti, Elena Kupert, K. Stroffekova, Ann M. Sherry, Danuta H. Malinowska, L. M. Knapp
Publikováno v:
The American journal of physiology. 273(2 Pt 1)
A ClC-2G(2 alpha) Cl- channel was identified to be present in human lung and stomach, and a partial cDNA for this Cl- channel was cloned from a human fetal lung library. A full-length expressible human ClC-2G(2 alpha) cDNA was constructed by ligation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bb356ded163174c45bc49ea84d45c84
https://pubmed.ncbi.nlm.nih.gov/9277336
https://pubmed.ncbi.nlm.nih.gov/9277336
Publikováno v:
The American journal of physiology. 268(1 Pt 1)
cDNA encoding a Cl- channel was isolated from a rabbit gastric library, sequenced, and expressed in Xenopus oocytes. The predicted protein (898 amino acids, relative molecular mass 98,433 Da) was overall 93% similar to the rat brain ClC-2 Cl- channel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ab346a9be5b07c7502cbeb09331d8e4
https://pubmed.ncbi.nlm.nih.gov/7840147
https://pubmed.ncbi.nlm.nih.gov/7840147