Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Ann M. Janowski"'
Autor:
Tyler K. Ulland, Nidhi Jain, Emma E. Hornick, Eric I. Elliott, Gwendolyn M. Clay, Jeffrey J. Sadler, Kathleen A. M. Mills, Ann M. Janowski, A. Paige Davis Volk, Kai Wang, Kevin L. Legge, Lokesh Gakhar, Mohammed Bourdi, Polly J. Ferguson, Mary E. Wilson, Suzanne L. Cassel, Fayyaz S. Sutterwala
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
The role of NLRP12 in immunity to bacterial infection is controversial as varied and contrasting results have been published using C57BL/6 mice. Here the authors shed light on this issue, showing that unlike C57BL/6N mice, C57BL/6J mice have a missen
Externí odkaz:
https://doaj.org/article/383567b1d23c49cca2e3d2f968f86070
Autor:
Ryan Kolb, Liem Phan, Nicholas Borcherding, Yinghong Liu, Fang Yuan, Ann M. Janowski, Qing Xie, Kathleen R. Markan, Wei Li, Matthew J. Potthoff, Enrique Fuentes-Mattei, Lesley G. Ellies, C. Michael Knudson, Mong-Hong Lee, Sai-Ching J. Yeung, Suzanne L. Cassel, Fayyaz S. Sutterwala, Weizhou Zhang
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Obesity is associated with higher breast cancer risk and poor prognosis. Here, the authors show that obesity promotes breast cancer through the recruitment of macrophages with activated NLRC4 inflammasome, which activate IL-1β production, resulting
Externí odkaz:
https://doaj.org/article/8dc39d9da6c541818c16001eb4cc7191
Publikováno v:
Frontiers in Immunology, Vol 4 (2013)
Inflammation plays a critical role in tumorigenesis and can contribute to oncogenic mutations, tumor promotion, and angiogenesis. Tumor promoting inflammation is driven by many factors including the presence of the pro-inflammatory cytokines interleu
Externí odkaz:
https://doaj.org/article/e1c7d21264424ee1a10f24e5dd4ccb5d
Autor:
Kathleen A. M. Mills, Nidhi Jain, Mohammed Bourdi, Suzanne L. Cassel, A. Paige Davis Volk, Gwendolyn M. Clay, Eric I. Elliott, Kai Wang, Jeffrey J. Sadler, Lokesh Gakhar, Fayyaz S. Sutterwala, Tyler K. Ulland, Ann M. Janowski, Emma E. Hornick, Mary E. Wilson, Polly J. Ferguson, Kevin L. Legge
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Nature Communications
Nature Communications
The inbred mouse strain C57BL/6J is widely used in models of immunological and infectious diseases. Here we show that C57BL/6J mice have a defect in neutrophil recruitment to a range of inflammatory stimuli compared with the related C57BL/6N substrai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13a4cd1a1558d7958144b789d5f18f18
https://doaj.org/article/383567b1d23c49cca2e3d2f968f86070
https://doaj.org/article/383567b1d23c49cca2e3d2f968f86070
Autor:
Lyse A. Norian, Jennifer M. McNiff, Suzanne L. Cassel, Weizhou Zhang, Ann M. Janowski, Matthew D. Martin, Oscar R. Colegio, Vladimir P. Badovinac, Emma E. Hornick, Fayyaz S. Sutterwala
Publikováno v:
Journal of Clinical Investigation. 126:3917-3928
Members of the NLR family can assemble inflammasome complexes with the adaptor protein ASC and caspase-1 that result in the activation of caspase-1 and the release of IL-1β and IL-18. Although the NLRC4 inflammasome is known to have a protective rol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88dd6da8aa008a4aa511ef97172be9ea
https://doi.org/10.1172/jci86953
https://doi.org/10.1172/jci86953
Autor:
Rahul, Vijay, Anthony R, Fehr, Ann M, Janowski, Jeremiah, Athmer, Dorthea L, Wheeler, Matthew, Grunewald, Ramakrishna, Sompallae, Samarchith P, Kurup, David K, Meyerholz, Fayyaz S, Sutterwala, Shuh, Narumiya, Stanley, Perlman
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 114(27)
Inflammatory responses to viral infections must be optimized to clear the pathogen without tissue damage. Inflammasomes comprise an important component of the innate immune response. Inflammasome activity must be carefully controlled to prevent a hyp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::81560790454690523ac6c457ac1ad0e1
https://pubmed.ncbi.nlm.nih.gov/28630327
https://pubmed.ncbi.nlm.nih.gov/28630327
Autor:
Samarchith P. Kurup, Jeremiah Athmer, Ann M. Janowski, Shuh Narumiya, Matthew E. Grunewald, Fayyaz S. Sutterwala, Anthony R. Fehr, Ramakrishna Sompallae, Dorthea L. Wheeler, David K. Meyerholz, Rahul Vijay, Stanley Perlman
Publikováno v:
Proceedings of the National Academy of Sciences
Prostaglandin D2 (PGD2), an eicosanoid with both pro- and anti-inflammatory properties, is the most abundantly expressed prostaglandin in the brain. Here we show that PGD2 signaling through the D-prostanoid receptor 1 (DP1) receptor is necessary for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35856a9085d78786a29df86e3c07e663
https://doi.org/10.1073/pnas.1704099114
https://doi.org/10.1073/pnas.1704099114
Publikováno v:
Protein & Cell
Chronic inflammatory responses have long been observed to be associated with various types of cancer and play decisive roles at different stages of cancer development. Inflammasomes, which are potent inducers of interleukin (IL)-1β and IL-18 during
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a50e002f26f3189a1acbf7ca89bd6ef
https://doi.org/10.1007/s13238-013-0001-4
https://doi.org/10.1007/s13238-013-0001-4
Autor:
Kathleen R. Markan, Suzanne L. Cassel, Fayyaz S. Sutterwala, Qing Xie, Wei Li, Nicholas Borcherding, Weizhou Zhang, Sai Ching J. Yeung, Yinghong Liu, Fang Yuan, Enrique Fuentes-Mattei, Ryan Kolb, C. Michael Knudson, Lesley G. Ellies, Matthew J. Potthoff, Mong Hong Lee, Ann M. Janowski, Liem Phan
Publikováno v:
Nature Communications
Nature communications, vol 7, iss 1
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Kolb, R; Phan, L; Borcherding, N; Liu, Y; Yuan, F; Janowski, AM; et al.(2016). Obesity-associated NLRC4 inflammasome activation drives breast cancer progression. NATURE COMMUNICATIONS, 7. doi: 10.1038/ncomms13007. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/6529s603
Nature communications, vol 7, iss 1
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Kolb, R; Phan, L; Borcherding, N; Liu, Y; Yuan, F; Janowski, AM; et al.(2016). Obesity-associated NLRC4 inflammasome activation drives breast cancer progression. NATURE COMMUNICATIONS, 7. doi: 10.1038/ncomms13007. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/6529s603
Obesity is associated with an increased risk of developing breast cancer and is also associated with worse clinical prognosis. The mechanistic link between obesity and breast cancer progression remains unclear, and there has been no development of sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77fd390807957b58d91d9f8a24c9c311
https://doi.org/10.1038/ncomms13007
https://doi.org/10.1038/ncomms13007