Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Ann M. Dorward"'
Autor:
Ema Yoshioka, Kaiwen Liu, Danyang Xu, Ann M. Dorward, Maria Licursi, Vipin Shankar Chelakkot, Kensuke Hirasawa, Shaykat Saha
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
The efficacy of aminolevulinic acid (5-ALA)-based photodynamic diagnosis (5-ALA-PDD) and photodynamic therapy (5-ALA-PDT) is dependent on the 5-ALA-induced cancer-specific accumulation of protoporphyrin IX (PpIX). We previously reported that inhibiti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adc52945664d2f51bb0c5a5a5aa5b8d8
https://pubmed.ncbi.nlm.nih.gov/33335181
https://pubmed.ncbi.nlm.nih.gov/33335181
Enhancement of Cancer-Specific Protoporphyrin IX Fluorescence by Targeting Oncogenic Ras/MEK Pathway
Autor:
Karen M. Mearow, Kensuke Hirasawa, Justin J. King, Mani Larijani, Theerawat Pongnopparat, Jayoti Som, Maria Licursi, Leena Derwish, Vipin Shankar Chelakkot, Suzette G Rutihinda, Ema Yoshioka, Ann M. Dorward
Publikováno v:
Theranostics
Protoporphyrin IX (PpIX) is an endogenous fluorescent molecule that selectively accumulates in cancer cells treated with the heme precursor 5-aminolevulinic acid (5-ALA). This cancer-specific accumulation of PpIX is used to distinguish tumor from nor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::470b288c66f1bda08d66813a8852af98
https://doi.org/10.7150/thno.22641
https://doi.org/10.7150/thno.22641
Autor:
Kathryn L. Shultz, Edward S. Yaskowiak, Kaitlyn R. Stanford, Kerri N. Smith, Wesley G. Beamer, Ann M. Dorward
Publikováno v:
Epigenetics
Females of the SWR/Bm (SWR) inbred mouse strain possess a unique susceptibility to juvenile-onset tumors originating from the granulosa cells (GC) of the ovarian follicles. Tumor susceptibility is an inherited, polygenic trait in SWR females, minimal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa1392c10982f2a2c3b85246135e4d83
https://doi.org/10.4161/epi.23399
https://doi.org/10.4161/epi.23399
Autor:
Marius Nap, Viveka Björklund, Thomas Stallmach, Zsuzsanna Varga, Heinrich Walt, Wesley G. Beamer, Mathie P.G. Leers, Ann M. Dorward, Barbara J. Tennent
Publikováno v:
Photodiagnosis and Photodynamic Therapy. 3:227-233
Summary Background Male transgenic mice expressing the human RAS gene on an FVB strain background develop adenocarcinoma of the breast between 7 and 8 weeks of age. We have utilized this mammary tumour model to investigate apoptotic responses followi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb532106831199d7690420e3465233f9
https://doi.org/10.1016/j.pdpdt.2006.07.002
https://doi.org/10.1016/j.pdpdt.2006.07.002
Publikováno v:
British Journal of Cancer
A photodynamic technique for human breast cancer detection founded upon the ability of tumour cells to rapidly accumulate the fluorescent product protoporphyrin IX (PpIX) has been applied to transgenic mouse models of mammary tumorigenesis. A major g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c37cd079d979b02d90c5ae8d0ba1f713
https://doi.org/10.1038/sj.bjc.6602840
https://doi.org/10.1038/sj.bjc.6602840
Autor:
Renhua Li, Gary A. Churchill, Wesley G. Beamer, Lindsay G. Horton, Kathryn L. Shultz, Ann M. Dorward
Publikováno v:
Cancer Research. 65:1259-1264
The spontaneous development of juvenile-onset ovarian granulosa cell tumors in mice of the SWXJ-9 recombinant inbred strain is a model for juvenile-type granulosa cell tumors that appear in very young girls. To expedite gene discovery in this mouse m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2ba185c478111c5466d437b0b63293b
https://doi.org/10.1158/0008-5472.can-04-2992
https://doi.org/10.1158/0008-5472.can-04-2992
Autor:
Richard C. Austin, Stephen G. Shaughnessy, Ann M. Dorward, Sudesh K. Sood, Sushmita Pamidi, Gurmit Singh, P. Andrew Outinen, Jeffrey I. Weitz
Publikováno v:
Journal of Biological Chemistry. 273:30808-30817
Mitochondrial abnormalities have been identified in hepatocytes of patients with hyperhomocysteinemia and in endothelial cells from the aortas of rats with diet-induced hyperhomocysteinemia. However, the mechanism by which homocysteine affects mitoch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e20fee0659be27604a8243a89d4d9e7f
https://doi.org/10.1074/jbc.273.46.30808
https://doi.org/10.1074/jbc.273.46.30808
Publikováno v:
Journal of Bioenergetics and Biomembranes. 29:385-392
Alterations in the biochemistry of mitochondria have been associated with cell transformation and the acquisition of drug resistance to certain chemotherapeutic agents, suggesting that mitochondria may play a supportive role for the cancer cell pheno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68355ebefb617de7942062f703f6c615
https://doi.org/10.1023/a:1022454932269
https://doi.org/10.1023/a:1022454932269
Publikováno v:
Endocrine-related cancer. 14(2)
The reproductive hormone environment is an important influence upon spontaneous ovarian granulosa cell (GC) tumor development in genetically susceptible (SWR × SWXJ-9) F1 female mice: androgenic support during puberty stimulates tumorigenesis, while
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::189cfe7e9b4854aa32a8af87eafc4c59
https://pubmed.ncbi.nlm.nih.gov/17639051
https://pubmed.ncbi.nlm.nih.gov/17639051
Autor:
Ann M, Dorward, Kathryn L, Shultz, Cheryl L, Ackert-Bicknell, Eva M, Eicher, Wesley G, Beamer
Publikováno v:
Cancer research. 63(23)
SWR/Bm (SWR) female mice spontaneously develop early-onset ovarian granulosa cell (GC) tumors that can progress to metastatic carcinoma and thus provide a model system for human, juvenile-type GC tumors. In SWR mice, GC tumor susceptibility is an inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::85abde88df034a1b1babb29ccd743dcb
https://pubmed.ncbi.nlm.nih.gov/14678975
https://pubmed.ncbi.nlm.nih.gov/14678975