Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Ann M. Donnelly"'
Autor:
Sheri L. Bonar, Adam Libby, Yao Min, Richard Weier, Michael B. Tollefson, Serge G. Wolfson, Michael Clare, Ann M. Donnelly, William E. Mcghee, Dominique Bonafoux, Patrick J. Lennon, Sumathy Mathialagan, Julia A. Guzova, Nandini Kishore, Cindy Sommers, Sharon Rouw, Lori Christine, Catherine S. Tripp
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:2870-2875
A series of 21 novel 2-[(aminocarbonyl)amino]-5-acetylenyl-3-thiophenecarboxamides were synthesized and evaluated for the inhibition of IKK-2. In spite of their often modest activity on the enzyme, six selected analogs showed significant inhibition o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::752b9930690fa8fa16c025496d6ce863
https://doi.org/10.1016/j.bmcl.2005.03.090
https://doi.org/10.1016/j.bmcl.2005.03.090
Autor:
Sumathy Mathialagan, Hymavathi Boddupalli, Q. Khai Huynh, Sharon Rouw, Gary Lange, Troii Hall, David Creely, Rodney G. Combs, Catherine S. Tripp, Ann M. Donnelly, Kuniko Kretzmer, Beverley Reitz, James Caroll, Nandini Kishore
Publikováno v:
Journal of Biological Chemistry. 277:13840-13847
NF-kappaB is sequestered in the cytoplasm by the inhibitory IkappaB proteins. Stimulation of cells by agonists leads to the rapid phosphorylation of IkappaBs leading to their degradation that results in NF-kappaB activation. IKK-1 and IKK-2 are two d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8e2af8226f4a10b1f6807157139c867
https://doi.org/10.1074/jbc.m110474200
https://doi.org/10.1074/jbc.m110474200
Publikováno v:
Journal of Biological Chemistry. 277:12550-12558
Nuclear factor-kappaB activation depends on phosphorylation and degradation of its inhibitor protein, IkappaB. The phosphorylation of IkappaBalpha on Ser(32) and Ser(36) is initiated by an IkappaB kinase (IKK) complex that includes a catalytic hetero
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1156e5228b5b2cb19e3d221838fb4879
https://doi.org/10.1074/jbc.m111526200
https://doi.org/10.1074/jbc.m111526200
Autor:
Jeng-Jong Shieh, Peter O. Olins, Maire Helena Caparon, William F. Hood, Kumnan Paik, Ann M. Donnelly, Bauer Christopher S, John P. McKearn, Sarah R. Braford, Polazzi Joseph O, John W. Thomas, Jon A. Klover, Alan Michael Easton, David L. Zeng, Mark Allen Abrams, Joseph K. Welply, Barbara K. Klein
Publikováno v:
Experimental Hematology. 27:1746-1756
A combinatorial mutagenesis strategy was used to create a collection of nearly 500 variants of human interleukin 3 (IL-3), each with four to nine amino acid substitutions clustered within four linear, nonoverlapping regions of the polypeptide. The va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad4c1a8be21dd8999107c60b154356b0
https://doi.org/10.1016/s0301-472x(99)00118-6
https://doi.org/10.1016/s0301-472x(99)00118-6
Autor:
Sharon Rouw, Adam Libby, Michael Clare, Horng-Chih Huang, Cynthia D. Sommers, Julia A. Guzova, Nandidni N. Kishore, Richard Weier, Sheri L. Bonar, Sumathy Mathialagan, Lori J. Vanella, Dominique Bonafoux, Jeanette L. Glaenzer, Koszyk Francis, Ann M. Donnelly, He Huang, David S. Oburn, Patrick J. Lennon, Catherine S. Tripp, Serge G. Wolfson
Publikováno v:
Bioorganicmedicinal chemistry. 18(1)
Series of aminopyridinecarboxamide-based inhibitors were synthesized and tested against human recombinant IKK-2 and in IL-1beta stimulated synovial fibroblasts. The 2-amino-5-chloropyridine-4-carboxamides were identified as the most potent inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c76055db0ef28806da346227b07a394
https://pubmed.ncbi.nlm.nih.gov/19914076
https://pubmed.ncbi.nlm.nih.gov/19914076
Autor:
Yiqing Feng, and Ann M. Donnelly, Joseph O. Polazzi, Edith S. Grabbe, Jeng-Jong Shieh, Barbara Kure Klein, Kumnan Paik, Linda L. Zurfluh, Mark P. Baganoff, John P. McKearn, Charles A. McWherter, William F. Hood, Ann L. Abegg
Publikováno v:
Biochemistry. 38(14)
Myelopoietins (MPOs) are a family of engineered dual interleukin-3 (IL-3) and granulocyte colony-stimulating factor (G-CSF) receptor agonists that are superior in comparison to the single agonists in their ability to promote the growth and maturation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::922d5df240c06e04c290d67fa2c4ff50
https://pubmed.ncbi.nlm.nih.gov/10194378
https://pubmed.ncbi.nlm.nih.gov/10194378